ChemicalBook > CAS DataBase List > GSK547

GSK547

Product Name
GSK547
CAS No.
2226735-55-1
Chemical Name
GSK547
Synonyms
RIP1I;GSK547;CPD3508;RIP1 inhibitor 547;RIP1 inhibitor GSK547;Inhibitor,RIP kinase,inhibit,GSK-547,GSK547,Receptor-interacting protein kinases,RIPK,GSK 547;(S)-6-(4-(5-(3,5-Difluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbonyl)piperidin-1-yl)pyrimidine-4-carbonitrile;4-Pyrimidinecarbonitrile, 6-[4-[[(5S)-5-(3,5-difluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]carbonyl]-1-piperidinyl]-
CBNumber
CB54806610
Molecular Formula
C20H18F2N6O
Formula Weight
396.39
MOL File
2226735-55-1.mol
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GSK547 Property

Boiling point:
578.3±60.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:65.0(Max Conc. mg/mL);163.98(Max Conc. mM)
pka
1.93±0.28(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biorbyt Ltd
Product number
orb573228
Product name
GSK547
Purity
>98%
Packaging
100mg
Price
$1802
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573228
Product name
GSK547
Purity
>98%
Packaging
250mg
Price
$3580.2
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573228
Product name
GSK547
Purity
>98%
Packaging
1g
Price
$5803.8
Updated
2021/12/16
DC Chemicals
Product number
DC12513
Product name
RIP1inhibitorGSK547
Purity
>98%
Packaging
1g
Price
$2300
Updated
2021/12/16
DC Chemicals
Product number
DC12513
Product name
RIP1inhibitorGSK547
Purity
>98%
Packaging
100mg
Price
$600
Updated
2021/12/16
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GSK547 Chemical Properties,Usage,Production

Biological Activity

GSK'547 is a highly selective and potent inhibitor of RIP1 (RIPK1) with a 400-fold increase in oral exposure compared to GSK'963 in mouse pharmacokinetic studies.

in vitro

In vitro, treatment with GSK'547 directed bone marrow-derived macrophages to develop an immunogenic phenotype, with up-regulation of MHC-II, TNFa and IFNg expression, and decreased CD206, IL- 10 and TGFb expression. In addition, it also up-regulated STAT1 signaling and decreased STAT3, STAT5 and STAT6 signaling in bone marrow-derived macrophages. Macrophages treated with GSK'547 had stronger ability to capture antigens.

in vivo

Mice were given GSK'547 through food, the concentration of GSK'547 in vivo was stable within 24 hours, which was higher than the IC50 value in L929 cells. GSK'547 maintained high concentrations in vivo during the 6-week administration. GSK'547 was well tolerated with no obvious pathological features. In mice with in situ pancreatic ductal adenocarcinoma, It reduced tumor burden and prolonged survival compared to control and Nec-1s-treated groups. GSK'547 prevents established tumors and liver metastases.

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GSK547 Preparation Products And Raw materials

Raw materials

Preparation Products

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2226735-55-1, GSK547Related Search:


  • GSK547
  • RIP1 inhibitor 547
  • RIP1I
  • CPD3508
  • (S)-6-(4-(5-(3,5-Difluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbonyl)piperidin-1-yl)pyrimidine-4-carbonitrile
  • RIP1 inhibitor GSK547
  • 4-Pyrimidinecarbonitrile, 6-[4-[[(5S)-5-(3,5-difluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]carbonyl]-1-piperidinyl]-
  • Inhibitor,RIP kinase,inhibit,GSK-547,GSK547,Receptor-interacting protein kinases,RIPK,GSK 547
  • 2226735-55-1
  • C20H18F2N6O
  • TargetValue
    RIP1
    ()