ChemicalBook > CAS DataBase List > 4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE
4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE
- Product Name
- 4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE
- CAS No.
- 90035-34-0
- Chemical Name
- 4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE
- Synonyms
- AKOS BAR-0197;4-[4-(TRIFLUOROMETHYL)PHENYL]BENZALDEHYDE;4'-Trifluoromethyl-biphenyl-4-carbaldehyde;4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE;4'-Trifluoromethylbiphenyl-4-carboxaldehyde;4'-(Trifluoromethyl)-Biphenyl-4-Carboxaldehyde;4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-CARBALDEHYDE;4'-(trifluoromethyl)-[1,1'-biphenyl]-4-carbaldehyde;4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-CARBOXALDEHYDE;[1,1'-Biphenyl]-4-carboxaldehyde,4'-(trifluoroMethyl)-
- CBNumber
- CB5482973
- Molecular Formula
- C14H9F3O
- Formula Weight
- 250.22
- MOL File
- 90035-34-0.mol
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4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE Property
- Melting point:
- 70-72°C
- Boiling point:
- 319.7±42.0 °C(Predicted)
- Density
- 1.251±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- color
- White to Light yellow
- CAS DataBase Reference
- 90035-34-0(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2916399090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- T3755
- Product name
- 4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $52
- Updated
- 2025/07/31
TCI Chemical
- Product number
- T3755
- Product name
- 4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $181
- Updated
- 2025/07/31
Usbiological
- Product number
- 291337
- Product name
- 4'-Trifluoromethylbiphenyl-4-carbaldehyde
- Packaging
- 500mg
- Price
- $333
- Updated
- 2021/12/16
TRC
- Product number
- T797165
- Product name
- 4''-Trifluoromethyl-biphenyl-4-carbaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 042875
- Product name
- 4'-(Trifluoromethyl)[1,1'-biphenyl]-4-carbaldehyde
- Purity
- >95%
- Packaging
- 5g
- Price
- $120
- Updated
- 2021/12/16
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4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE Chemical Properties,Usage,Production
Synthesis
128796-39-4
1122-91-4
90035-34-0
Step A: To a round bottom flask was added 4-bromobenzaldehyde (69.6 g, 376 mmol), 4-(trifluoromethyl)phenylboronic acid (75.0 g, 395 mmol), and 1-propanol (appropriate amount), and the reaction mixture was stirred for 15 min at 70 °C until a clarified solution was obtained. Triphenylphosphine (888 mg, 3.38 mmol), palladium(II) acetate (256 mg, 1.13 mmol), 2M aqueous sodium carbonate (226 mL, 451 mmol), and water (138 mL) were sequentially added to the resulting solution. The reaction system was heated and refluxed for 1 hour, keeping the system open to air. Upon completion of the reaction, water (900 mL) was added and the reaction mixture was cooled to 7°C. Stirring was continued for 30 minutes until 4'-(trifluoromethyl)biphenyl-4-carbaldehyde was completely precipitated. The precipitate was collected by filtration and the solid was washed with cold water (~600 mL). The solid was dissolved in diethyl ether (500 mL), filtered through a pad of diatomaceous earth and silica, and the filter cake was washed with diethyl ether (2 x 500 mL). The filtrate was concentrated under reduced pressure to give 4'-(trifluoromethyl)biphenyl-4-carbaldehyde (90.0 g, 96% yield) as a pure white solid. The product was confirmed structurally by 1H NMR (400 MHz, CDCl3, δ): 7.75 (s, 4H), 7.76-7.79 (m, 2H), 7.96-8.04 (m, 2H), 10.10 (s, 1H). Mass spectrometry (MS) showed [M + 1] peak at 250.3.
References
[1] Patent: US2012/165343, 2012, A1. Location in patent: Page/Page column 15
[2] Applied Organometallic Chemistry, 2012, vol. 26, # 9, p. 478 - 482
[3] Patent: WO2005/118542, 2005, A1. Location in patent: Page/Page column 43; 55-56
[4] Green Chemistry, 2011, vol. 13, # 1, p. 169 - 177
[5] ChemMedChem, 2016, p. 2194 - 2204
4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE manufacturers
Hebei Best Biological Technology Co., Ltd
- Product
- 4'-Trifluoromethyl-biphenyl-4-carbaldehyde 90035-34-0
- Price
- US $200.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 1000t/month
- Release date
- 2022-12-01
Shaanxi Dideu Medichem Co. Ltd
- Product
- 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene 898566-17-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 5g
- Purity
- 98% HPLC
- Supply Ability
- 100 tons
- Release date
- 2019-12-25
Shaanxi Dideu Medichem Co. Ltd
- Product
- 4'-(trifluoromethyl)-[1,1'-biphenyl]-4-carbaldehyde 90035-34-0
- Price
- US $0.00-0.00/g
- Min. Order
- 5g
- Purity
- 99%+
- Supply Ability
- 100 tons
- Release date
- 2019-12-25
90035-34-0, 4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDERelated Search:
4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID
4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE
2'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE,2'-Trifluoromethyl-biphenyl-4-carbaldehyde
4-(TRIFLUOROMETHYL)-BIPHENYL
1-(4'-TRIFLUOROMETHYL-BIPHENYL-4-YL)-ETHANONE
4'-TRIFLUOROMETHYL-BIPHENYL-2-CARBALDEHYDE
3'-TRIFLUOROMETHYL-BIPHENYL-2-CARBALDEHYDE
3',5'-DI-(TRIFLUOROMETHYL)-BIPHENYL-4-CARBALDEHYDE
2'-TRIFLUOROMETHYL-BIPHENYL-2-CARBALDEHYDE
4'-TRIFLUOROMETHYL-BIPHENYL-3-CARBALDEHYDE,4'-Trifluoromethyl-biphenyl-3-carbaldehyde
2'-TRIFLUOROMETHYL-BIPHENYL-3-CARBALDEHYDE,2'-Trifluoromethyl-biphenyl-3-carbaldehyde
3',5'-DI-(TRIFLUOROMETHYL)-BIPHENYL-3-CARBALDEHYDE
3'-Trifluoromethyl-biphenyl-4-carbaldehyde
4'-FLUORO-3'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE
4'-FLUORO-3'-TRIFLUOROMETHYL-BIPHENYL-3-CARBALDEHYDE
AKOS BAR-2205
RARECHEM AL BI 1218
AKOS BAR-2067