tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate

Product Name: tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate
CAS No.: 154026-95-6
Chemical Name: tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate
Synonyms: RosuvastatinD5;Rosuvastatin P-1;tert-butyl 2-((4R;tert-Butyl (4R-cis)-;TERT BUTYL(4R-CIS)-6;3-dioxan-4-yl)acetate;6S)-6-(acetoxyMethyl)-2; Pitavastatin Impurity 62;Rosuvastatin EP Impurity C4;Rosuvastatin Intermediate D5
CBNumber: CB5484937
Molecular Formula: C15H26O6
Formula Weight: 302.36
MOL File: 154026-95-6.mol

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tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate Property

Boiling point:: 353.1±22.0 °C(Predicted)
Density: 1.036±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: Off-White
InChI: InChI=1S/C15H26O6/c1-10(16)18-9-12-7-11(19-15(5,6)20-12)8-13(17)21-14(2,3)4/h11-12H,7-9H2,1-6H3/t11-,12-/m0/s1
InChIKey: NGABCYSYENPREI-RYUDHWBXSA-N
SMILES: C(OC(C)(C)C)(=O)C[C@@H]1C[C@@H](COC(=O)C)OC(O1)(C)C
CAS DataBase Reference: 154026-95-6(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

TRC

Product number: T117700
Product name: Tert-butyl2-[(4R,6S)-2,2-Dimethyl-6-[(methylcarbonyloxy)methyl]-1,3-dioxan-4-yl]acetate
Packaging: 10g
Price: $80
Updated: 2021/12/16

Matrix Scientific

Product number: 126406
Product name: tert-Butyl(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate
Purity: >95%
Packaging: 1g
Price: $82
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0000010
Product name: (4R-CIS)-6-[(ACETYLOXY)METHYL]-2,2-DIMETHYL-1,3-DIOXANE-4 ACETIC ACID,1,1-DIMETHYLETHYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $168
Updated: 2021/12/16

AK Scientific

Product number: 3539CR
Product name: Tert-Butyl(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate
Packaging: 100g
Price: $215
Updated: 2021/12/16

Matrix Scientific

Product number: 126406
Product name: tert-Butyl(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate
Purity: >95%
Packaging: 5g
Price: $244
Updated: 2021/12/16

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tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate Chemical Properties,Usage,Production

Chemical Properties

White or grey white solid powder

Uses

Tert-butyl 2-[(4R,6S)-2,2-Dimethyl-6-[(methylcarbonyloxy)methyl]-1,3-dioxan-4-yl]acetate (Rosuvastatin Impurity 19) is an impurity of Rosuvastatin (R700500), a selective and competitive HMG-CoA reductase inhibitor.

Synthesis

124655-09-0

75-36-5

154026-95-6

Tert-butyl (4R,6S)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate (1.0 g, 3.84 mmol) was dissolved in 10 mL of dichloromethane, and pyridine (0.9 g, 11.52 mmol) was added at room temperature and stirred for 30 min. Acetyl chloride (0.66 g, 8.45 mmol) was then added and stirring was continued at room temperature for 1 hour. After completion of the reaction, 10 mL of water was added to the mixture and the organic layer was separated by stirring for 10 minutes. The aqueous layer was extracted twice with 5 mL of dichloromethane, the organic layers were combined and washed with 10 mL of water to separate the organic layer. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford 0.98 g (86% yield) of the target product (4R,6S)-tert-butyl (4R,6S)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate as light pink crystals.

References

[1] Patent: KR2016/126700, 2016, A. Location in patent: Paragraph 0161; 0162-0165
[2] Journal of Organic Chemistry, 2011, vol. 76, # 22, p. 9444 - 9451

tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate 154026-95-6
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000 KGS
Release date: 2021-06-29

Hebei Chuanghai Biotechnology Co., Ltd

Product: tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate 154026-95-6
Price: US $25.00/kg
Min. Order: 100kg
Purity: 99.5%
Supply Ability: 100 mt
Release date: 2024-10-30

Henan Aochuang Chemical Co.,Ltd.

Product: tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate 154026-95-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

154026-95-6, tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetateRelated Search:

N,N-Dimethylformamide Sodium triacetoxyborohydride Dimethyl sulfoxide 1,4-Dioxane Methyl acetate Benzyloxyacetyl chloride Diethoxydimethylsilane Dimethyldimethoxysilane Acetyl tributyl citrate Selenium dioxide tert-Butyl acetate Ethyl 2-(Chlorosulfonyl)acetate Dimethyl fumarate Butyl acetate ETHANE Dimethyl carbonate (4R-Cis)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester Dimethyl ether

Rosuvastatin Calcium Impurity 7

Rosuvastatin P-1

Pitavastatin Impurity 62

(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate

Rosuvastatin EP Impurity C4

tert-butyl (4r-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate

(4r-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester

(4R-CIS)-6-[(ACETYLOXY)METHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETIC ACID, T-BUTYL ESTER

2-[(4R,6S)-6-(Acetoxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert-buthyl ester

(4R-CIS)-6-[ (ACETYLOXY)METHYL ]-2,2-DIMETHYL-1,

(4r-Cis)6[(Acetyloxymethyl)]-2,2-Dimethyl-1,3-Dimethyl-1,3-Dioxane-4-Acetic Acid, 1,1-Dimethylethyl Ester

tert-Butyl (4R-cis)-

(4R-Cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid,1,1-dimethylethyl ester(D5)

High quality ISO & BV Factory (4R-cis)...

(4R-Cis)-6-[(Acetyloxy)Methy]-2,2-diMethyl-1,3-dioxane-4-acetic acid,1,1-diMenthylethyl ester

tert-Butyl 2-[(4R,6S)-6-(AcetoxyMethyl)-2,2-diMethyl-1,3-dioxan-4-yl]acetate

rosuvastatin interMediates D-5

3-dioxan-4-yl)acetate

6S)-6-(acetoxyMethyl)-2

tert-butyl 2-((4R

2-[(4R,6S)-6-(AcetoxyMethyl)-2,2-diMethyl-1,3-dioxan-4-yl]acetic acid tert-butyl ester

Rosuvastatin CalciuM InterMediate D5 (4R-Cis)-6-[(acetyloxy)Methyl]-2,2-diMethyl-1,3-diox ane-4-acetic acid,1,1-diMethylethyl ester

D-5: (4R-CIS)-6-[(ACETYLOXY)METHYL]-2,2-DIMETHYL-<BR>1,3-DIOXANE-4-ACETIC ACID,1,1-DIMETHYLETHYL ESTER

tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate(D5)

D-erythro-Hexonic acid, 2,4-dideoxy-3,5-O-(1-methylethylidene)-, 1,1-dimethylethyl ester, 6-acetate

TERTIARY BUTYL 4R, CIS 6-ACETYLOXY METHYL 2, 2 DIMETHYL 1, 3 DIOXANE 4-ACETATE

tert-Butyl 2-[(4R,6S)-6-(acetyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate

ert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate

Rosuvastatin Intermediate D5

2,4-dideoxy-3,5-O-(1-methylethylidene)-D-erythro-Hexonic acid 1,1-dimethylethyl ester 6-acetate

TERT BUTYL(4R-CIS)-6

RosuvastatinD5

4R-cis-6-[Acetoxymethyl]-2,2-dimethyl-1,3-dioxane-4-aceticacidtert-butylester

(4R-cis)-tert-Butyl6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate

2,4-Dideoxy-3,5-o-(1-methylethylidene)-D-erythro-hexonic acid tert-butyl ester 6-acetate

154026-95-6

rosuvastatin intermediates

INTERMEDIATES OF ROSUVASTATIN