Desthiobiotin-PEG4-DBCO
- Product Name
- Desthiobiotin-PEG4-DBCO
- CAS No.
- 2032788-37-5
- Chemical Name
- Desthiobiotin-PEG4-DBCO
- Synonyms
- Desthiobiotin-PEG4-DBCO;Desthiobiotin-PEG4-CONH-DBCO
- CBNumber
- CB54849431
- Molecular Formula
- C39H53N5O8
- Formula Weight
- 719.88
- MOL File
- 2032788-37-5.mol
Desthiobiotin-PEG4-DBCO Property
- Boiling point:
- 1013.4±65.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- pka
- 14.93±0.60(Predicted)
- form
- Oil
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- BP-22451
- Product name
- DBCO-PEG4-Desthiobiotin
- Purity
- 95%
- Packaging
- 5mg
- Price
- $179
- Updated
- 2021/12/16
Desthiobiotin-PEG4-DBCO Chemical Properties,Usage,Production
Description
DBCO-PEG4-Desthiobiotin is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kd?= 1011?vs. 1015M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin. For pull-down experiments with biological samples, this soft-release characteristic of desthiobiotin also helps to minimize co-purification of endogenous biotinylated molecules, which remain bound to streptavidin upon elution of the target protein complexes with free biotin. DBCO is commonly used for copper-free Click Chemistry reactions.
Uses
DBCO-PEG4-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG4-Desthiobiotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Desthiobiotin-PEG4-DBCO Preparation Products And Raw materials
Raw materials
Preparation Products
Desthiobiotin-PEG4-DBCO Suppliers
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 027-65563561
- Fax
- 86-27-59218822
- sales@borenpharm.com
- Country
- China
- ProdList
- 1245
- Advantage
- 55
- Tel
- +86-156-80926068 +86-15680926068
- 1924344760@qq.com
- Country
- China
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- 4952
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- 58
- Tel
- +1-5166625404;
- Fax
- 1-516-927-0118
- Info@alfa-chemistry.com
- Country
- United States
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- 20405
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- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
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- 58
- Tel
- 13892832556
- 2440688701@qq.com
- Country
- China
- ProdList
- 1994
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- 58
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- +86-13759708231
- asherw9@hotmail.com
- Country
- China
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- 2373
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- 58
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- 17612188245
- Fax
- QQ 2816925681
- 2816925681@qq.com
- Country
- China
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- 2989
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- 58
- Tel
- 020-82000279 18988941452
- Fax
- QQ：3283937693
- YN_research@163.com
- Country
- China
- ProdList
- 3011
- Advantage
- 58
- Tel
- 021-51816796-820 13611835272
- Fax
- 021-5161 3951
- sales2@sunwaypharm.com
- Country
- China
- ProdList
- 44119
- Advantage
- 58
View Lastest Price from Desthiobiotin-PEG4-DBCO manufacturers
- Product
- Desthiobiotin-PEG4-CONH-DBCO 2032788-37-5
- Price
- US $0.00/mg
- Min. Order
- 25mg
- Purity
- >99.00%
- Supply Ability
- 25mg
- Release date
- 2024-03-30