Desthiobiotin-PEG4-Alkyne
- Product Name
- Desthiobiotin-PEG4-Alkyne
- CAS No.
- 1802907-99-8
- Chemical Name
- Desthiobiotin-PEG4-Alkyne
- Synonyms
- Desthiobiotin-PEG4-Alkyne;4-Imidazolidinehexanamide, 5-methyl-2-oxo-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl-, (4R,5S)-rel-
- CBNumber
- CB73345013
- Molecular Formula
- C21H37N3O6
- Formula Weight
- 427.54
- MOL File
- 1802907-99-8.mol
Desthiobiotin-PEG4-Alkyne Property
- Boiling point:
- 649.0±50.0 °C(Predicted)
- Density
- 1.075±0.06 g/cm3(Predicted)
- pka
- 14.93±0.60(Predicted)
N-Bromosuccinimide Price
- Product number
- BP-22685
- Product name
- Desthiobiotin-PEG4-Alkyne
- Purity
- 90%
- Packaging
- 5mg
- Price
- $79
- Updated
- 2021/12/16
Desthiobiotin-PEG4-Alkyne Chemical Properties,Usage,Production
Description
Desthiobiotin is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kd = 1011 vs. 1015M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin. For pull-down experiments with biological samples, this soft-release characteristic of desthiobiotin also helps to minimize co-purification of endogenous biotinylated molecules, which remain bound to streptavidin upon elution of the target protein complexes with free biotin.
Uses
Desthiobiotin-PEG4-alkyne is a biotinylated biochemical reagent, which can be utilized in conjunction with click chemistry for the selective labeling and enrichment of certain tRNAs[1].
References
[1] Krasheninina OA, et al., Amine-to-Azide Conversion on Native RNA via Metal-Free Diazotransfer Opens New Avenues for RNA Manipulations. Angew Chem Int Ed Engl. 2021 Mar 22;60(13):6970-6974. DOI:10.1002/anie.202015034
Desthiobiotin-PEG4-Alkyne Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Desthiobiotin-PEG4-Alkyne manufacturers
- Product
- Desthiobiotin-PEG4-Alkyne 1802907-99-8
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- >98.00%
- Supply Ability
- 5mg
- Release date
- 2024-03-21