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Succinimidyl 6-(biotinamido)hexanoate

Product Name
Succinimidyl 6-(biotinamido)hexanoate
CAS No.
72040-63-2
Chemical Name
Succinimidyl 6-(biotinamido)hexanoate
Synonyms
Bachs;BIOTIN-X-NHS;BIOTIN-X, SE;NHS-X-Biotin;D-Biotiamide;NHS-LC-BIOTIN;BIOTIN-LC-OSU;Biotin-LC-NHS;Biotin-NHS LC;BIOTIN-AC5-OSU
CBNumber
CB2343655
Molecular Formula
C20H30N4O6S
Formula Weight
454.54
MOL File
72040-63-2.mol
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Succinimidyl 6-(biotinamido)hexanoate Property

Melting point:
169-171 °C
Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
H2O: ≤2 mg/mL with sonication
form 
powder
pka
13.90±0.40(Predicted)
color 
White to Off-White
BRN 
3577403
Stability:
Moisture Sensitive
InChIKey
UVGHPGOONBRLCX-NJSLBKSFSA-N
CAS DataBase Reference
72040-63-2(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
WGK Germany 
3
10-21
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B2643
Product name
Biotinamidohexanoic acid N-hydroxysuccinimide ester
Purity
≥98% (TLC), powder
Packaging
10mg
Price
$45.5
Updated
2024/03/01
Sigma-Aldrich
Product number
B2643
Product name
Biotinamidohexanoic acid N-hydroxysuccinimide ester
Purity
≥98% (TLC), powder
Packaging
25mg
Price
$121
Updated
2024/03/01
Sigma-Aldrich
Product number
203189
Product name
Biotin-X-NHS, Water-Soluble
Packaging
50MG
Price
$764
Updated
2024/03/01
TCI Chemical
Product number
S0490
Product name
N-Succinimidyl 6-Biotinamidohexanoate
Purity
>97.0%(HPLC)
Packaging
20mg
Price
$52
Updated
2024/03/01
TCI Chemical
Product number
S0490
Product name
N-Succinimidyl 6-Biotinamidohexanoate
Purity
>97.0%(HPLC)
Packaging
100mg
Price
$166
Updated
2024/03/01
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Succinimidyl 6-(biotinamido)hexanoate Chemical Properties,Usage,Production

Description

Biotin-LC-NHS Ester has an extended spacer arm which helps to minimize steric hindrance. The membrane permeability of this reagent allows it to be used for intracellular labeling. It can react efficiently with primary amino (-NH2) to form stable, irreversible amide bonds.

Chemical Properties

Succinimidyl 6-(biotinamido)hexanoate is White Solid

Uses

Succinimidyl 6-(biotinamido)hexanoate is a biotinylation reagent incorporating an aminocaproyl “spacer”. This can reduce the steric hindrance in binding avidin to some biotinylated compounds when used to biotinylate both the antibody and the carrier in the Protein Avidin-Biotin Capture System. This system avoids the direct interaction of a captured antibody with solid surfaces, such as plastics, which may reduce antigenicity. It has also been used to enhance the detection of DNA on nitrocellulose. Has also been used as a cell surface labelling reagent

Uses

Has been used to biotinylate both the antibody and the carrier in the Protein Avidin-Biotin solid surfaces, such as plastics, which may reduce antigenicity. It has also been used to enhance the detection of DNA on nitrocellulose. Spacer Arm:

Uses

A biotinylation reagent incorporating an aminocaproyl pacer? This can reduce the steric hindrance in binding avidin to some biotinylated compounds when used to biotinylate both the antibody and the carrier in the Protein Avidin-Biotin Capture Sy

Biological Activity

nhs-lc-biotin (succinimidyl-6-(biotinamindo)hexanoate), also known as nhs-x-biotin is a derivative of d-biotin, a amine-reactive biotinylation agent, that contains a spacer arm off the valeric acid side chain of d-biotin with an nhs ester group at its end. the nhs ester group at the end of nhs-lc-biotin covalently binds to amine groups in proteins and other molecules forming a stable amide linkage and releasing the nhs group. the 6-aminocaproic acid spacer of nhs-lc-biotin greatly increases the length between a covalently modified molecule and the bicyclic biotin rings leading to a better binding potential for avidin or streptavidin probes. nhs-lc-biotin is insoluble in aqueous environments requiring the dissolution of organic solvents prior to the addition to a buffered reaction.bioconjugate techniques , 2nd ed. by greg t.hermanson (pierce biotechnology, thermo fisher scientific, rockford, il). academic press (an imprint of elsevier): london, amsterdam, burlington, san diego . 2008. isbn 978-0-12-370501-3.

storage

Store at -20°C

Purification Methods

Dissolve ~400mg of the ester in dry propan-2-ol (~25mL) with gentle heating. Reduce the volume to ~10mL by gentle boiling and allow the solution to cool. Decant the supernatant carefully from the white crystals, dry the crystals in a vacuum over P2O5 at 60o overnight. This material gives one spot on TLC. [Costello et al. Clin Chem 25 1572 1979, Kincaid et al. Methods Enzymol 159 619 1988.]

Succinimidyl 6-(biotinamido)hexanoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Succinimidyl 6-(biotinamido)hexanoate Suppliers

Wanxin Biotechnology (Jiaxing) Co., LTD
Tel
0573-83568680 18057391398
Email
3956524501@qq.com
Country
China
ProdList
1442
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Biomatrik (Jiaxing) Inc.
Tel
573-573-82623377 18967387295
Fax
+86 (573) 8262-3317
Email
sales@biomatrik.cn
Country
China
ProdList
70
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
Advantage
57
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View Lastest Price from Succinimidyl 6-(biotinamido)hexanoate manufacturers

R&D Scientific Inc.
Product
D-Biotiamide 72040-63-2
Price
US $6500.00/G
Min. Order
1G
Purity
97
Supply Ability
500 Kg
Release date
2024-06-23
Xian confluore Biological Technology Co., Ltd.
Product
Biotin-LC-NHS 72040-63-2
Price
US $0.00/g
Min. Order
5g
Purity
>95.00%
Supply Ability
5g
Release date
2024-03-30
Zhuozhou Wenxi import and Export Co., Ltd
Product
Succinimidyl 6-(biotinamido)hexanoate 72040-63-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

72040-63-2, Succinimidyl 6-(biotinamido)hexanoateRelated Search:


  • 6-[5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-4-YL)-PENTANOYLAMINO]-HEXANOIC ACID 3-HYDROPEROXYSULFONYL-2,5-DIOXO-PYRROLIDIN-1-YL ESTER SODIUM SALT
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  • BIOTIN-X-NHS, WATER-SOLUBLE
  • BIOTIN-X, SE
  • BIOTIN-X, SUCCINIMIDYL ESTER
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  • N-SUCCINIMIDYL N-BIOTINYL-6-AMINOCAPROATE
  • NHS-LC-BIOTIN
  • SULFO-NHS-LC-BIOTIN
  • SULFOSUCCINIMIDYL-6-(BIOTINAMIDO)HEXANOATE
  • SULFOSSUCCINIMIDYL-6-(BIOTINAMIDO)HEXANOATE
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  • SULFOBIOTIN-X-NHS
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  • 2,5-Dioxopyrrolidin-1-yl 6-(5-((3aS,4S,6aR)
  • 2,5-Dioxopyrrolidin-1-yl 6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)penta
  • Biotinamidohexanoic acidN-hydroxysuccinimide ester≥ 97% (HPLC)
  • Biotinyl-ε-aminocaproic acid-N-hydroxysuccinimide ester
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  • BIOTIN-LC-OSU
  • N-(+)-BIOTINYL-6-AMINOCAPROIC ACID N-SUCCINIMIDYL ESTER
  • Biotin-X, SE [Biotimidohexanoic acid N-hydroxysuccinimide ester]
  • Biotin-N-succinimidyl-amidohexanoate
  • CAS_72040-63-2
  • (+)-Biotinamidocaproate N-hydroxysuccinimidyl ester, N-(+)-Biotinyl-6-aminocaproic acid N-succinimidyl ester, N-(+)-Biotinyl-6-aminohexanoic acid NHS ester, N-Succinimidyl N-biotinyl-6-aminocaproate, Succinimidyl 6-(biotinamido)hexanoate
  • LC-NHS-(+)-Biotin
  • N-(+)-Biotinyl-6-aminohexanoic acid NHS ester
  • 1H-Thieno(3,4-D)imidazole-4-pentanamide, N-(6-((2,5-dioxo-1-pyrrolidinyl)oxy)-6-oxohexyl)hexahydro-2-oxo-, (3as-(3aalpha,4beta,6aalpha))-
  • 1H-Thieno(3,4-D)imidazole-4-pentanamide, N-(6-((2,5-dioxo-1-pyrrolidinyl)oxy)-6-oxohexyl)hexahydro-2-oxo-, (3as,4S,6ar)-
  • Bachs
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  • N-Biotinyl-epsilon-aminocaproic acid N-hydroxysuccinimide ester
  • Biotinamidohexanoic acid N-hydroxysuccinimide ester,(+)-Biotinamidocaproate N-hydroxysuccinimidyl ester, N-(+)-Biotinyl-6-aminocaproic acid N-succinimidyl ester, N-(+)-Biotinyl-6-aminohexanoic acid NH
  • Biotin-6-aMinohexanoic acid-N-hydroxysucciniMide ester
  • Biotin-LC-NHS
  • 2,5-dioxopyrrolidin-1-yl 6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]iMidazol-4-yl)pentanaMido)hexanoate
  • N-SucciniMidyl 6-BiotinaMidohexanoate
  • Hexanoic acid, 6-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]iMidazol-4-yl]-1-oxopentyl]aMino]-, 2,5-dioxo-1-pyrrolidinyl ester
  • NHS-X-Biotin
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