BIOTIN HPDP

Product Name: BIOTIN HPDP
CAS No.: 129179-83-5
Chemical Name: BIOTIN HPDP
Synonyms: Biotin Impurity 31;Pyridyldithiol-biotin;Biotin HPDP,BiotinHPDP;Pyridyldisulfide-biotin;Ciprofibrate Impurity 6;Biotin-HPDP, 10 mM in DMSO;Macamide Impurity 11(Biotin HPDP);Biotin-HPDP, Sulfhydryl-reactive biotinylation reagent;N-[6-(Biotinamido)hexyl]-3’-(2-pyridyldithio)propionamide;N-[6-(Biotinamido)hexyl]-3'-(2'-pyridyldithio)propionamide
CBNumber: CB6500704
Molecular Formula: C24H37N5O3S3
Formula Weight: 539.78
MOL File: 129179-83-5.mol

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BIOTIN HPDP Property

Melting point:: 160-163°C
Boiling point:: 876.0±65.0 °C(Predicted)
Density: 1.28
storage temp.: -20°C Freezer
solubility: insoluble in H2O; ≥101.4 mg/mL in DMSO; ≥8.29 mg/mL in EtOH with ultrasonic
pka: 13.90±0.40(Predicted)
form: powder to crystal
color: White to Light yellow
InChIKey: QLPHBNRMJLFRGO-YDHSSHFGSA-N
SMILES: C1(=O)N[C@]2([H])[C@H](CCCCC(NCCCCCCNC(=O)CCSSC3=NC=CC=C3)=O)SC[C@]2([H])N1

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Safety

HS Code: 2934.99.4400

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5749
Product name: Biotin-HPDP
Packaging: 25MG
Price: $108
Updated: 2025/07/31

TCI Chemical

Product number: B5749
Product name: Biotin-HPDP
Packaging: 100MG
Price: $296
Updated: 2025/07/31

Cayman Chemical

Product number: 16459
Product name: Biotin-HPDP
Purity: ≥95%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16459
Product name: Biotin-HPDP
Purity: ≥95%
Packaging: 10mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 16459
Product name: Biotin-HPDP
Purity: ≥95%
Packaging: 50mg
Price: $230
Updated: 2024/03/01

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BIOTIN HPDP Chemical Properties,Usage,Production

Description

Biotin-HPDP is a sulfhydryl-reactive biotinylation reagent that forms a reversible disulfide linkage. It is used to label protein cysteines and other substrates that contain sulfhydryl groups. Biotin-HPDP is also used in the biotin switch technique to tag S-nitrosylated (SNO) proteins, following reduction of SNO groups to thiols. Compounds that are tagged with biotin interact avidly with streptavidin-coupled beads, fluorophores, enzymes, etc. The interaction of biotin-HPDP with substrates containing sulfhydryl groups is easily performed at pH 6.5 to 7.5 in buffers such as PBS. The disulfide linkage that is formed between avidin and substrate can later by cleaved by a reducing agent, like dithiothreitol.

Chemical Properties

Pale Yellow Solid

Uses

This compounds reacts specifically with thiol groups.

References

[1] CHANGYUAN LU. S-sulfhydration/desulfhydration and S-nitrosylation/denitrosylation: A common paradigm for gasotransmitter signaling by H2S and NO[J]. Methods, 2013, 62 2: Pages 177-181. DOI: 10.1016/j.ymeth.2013.05.020
[2] S. SLATIN. Translocation of a functional protein by a voltage-dependent ion channel[J]. Proceedings of the National Academy of Sciences of the United States of America, 2002, 99 1: 1286-1291. DOI: 10.1073/pnas.022480199
[3] OSCAR A. BIZZOZERO Jianzheng Z. Identification of major S-nitrosylated proteins in murine experimental autoimmune encephalomyelitis[J]. Journal of Neuroscience Research, 2009, 87 13: 2881-2889. DOI: 10.1002/jnr.22113
[4] KARINA CKLESS . In situ detection and visualization of S-nitrosylated proteins following chemical derivatization: identification of Ran GTPase as a target for S-nitrosylation[J]. Nitric oxide?: biology and chemistry, 2004, 11 3: Pages 216-227. DOI: 10.1016/j.niox.2004.06.002
[5] MICHAEL T FORRESTER Jonathan S S Matthew W Foster. Assessment and application of the biotin switch technique for examining protein S-nitrosylation under conditions of pharmacologically induced oxidative stress.[J]. The Journal of Biological Chemistry, 2007, 282 19: 13977-13983. DOI: 10.1074/jbc.m609684200

BIOTIN HPDP Preparation Products And Raw materials

Raw materials

Preparation Products

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BIOTIN HPDP Suppliers

Americas 1 Canada 1 China 87 Europe 1 Germany 1 India 2 Japan 2 United Kingdom 1 United States 11 Global 107

HINOVA PHARMACEUTICALS INC.

Tel: 18244267397
Email: cxinghua127@163.com
Country: China
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Shanghai Boyle Chemical Co., Ltd.

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Fax: 86-21-57758967
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
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Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
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Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
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Beijing HuaMeiHuLiBiological Chemical

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TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
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TCI Europe

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TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
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View Lastest Price from BIOTIN HPDP manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Biotin-HPDP 129179-83-5
Price: US $0.00/mg
Min. Order: 250mg
Purity: >95.00%
Supply Ability: 250mg
Release date: 2024-03-30

129179-83-5, BIOTIN HPDPRelated Search:

3-[2-N-(BIOTINYL)AMINOETHYLDITHIO]PROPANOIC ACID BIOTINAMIDOCAPROYL HYDRAZIDE 1-BiotinaMido-4-[4`-(MaleiMidoMethyl)cyclohexanecarboxaMido]butane(Biotin-BMCC) Azide-PEG3-Desthiobiotin Desthiobiotin-PEG4-Alkyne Biotin-PEG3-Mal N-Biotinyl-N'-(3-maleimidopropionyl)-3,6-dioxaoctane-1,8-diamine DESTHIOBIOTIN N-HYDROXYSUCCINIMIDYL ESTER biotinylamidoethylacetamide SULPHOSUCCINIMIDYL-6-(BIOTINAMIDO)HEXANOATE (+)-BIOTIN-EPSILON-AMINOCAPROIC ACID Succinimidyl 6-(biotinamido)hexanoate D-DESTHIOBIOTIN BIOTIN-4-FLUORESCEIN UV-Tracer Biotin NHS Ester N-(3-Azidopropyl)biotinaMide 1H-Thieno[3,4-d]iMidazole-4-pentanaMide, hexahydro-N-[2-(4-hydroxyphenyl)ethyl]-2-oxo-, (3aS,4S,6aR)- 1H-Thieno[3,4-d]iMidazole-4-pentanaMide, hexahydro-2-oxo-N-2-propynyl-, (3aS,4S,6aR)-

(3aS,4S,6aR)-Hexahydro-2-oxo-N-[6-[[1-oxo-3-(2-pyridinyldithio)propyl]amino]hexyl]-1H-thieno[3,4-d]imidazole-4-pentanamide

N-[6-(Biotinamido)hexyl]-3'-(2'-pyridyldithio)propionamide

N-[6-(BiotinaMido)hexyl]-3`-(2`-pyridyldithio)propionaMide(Biotin-HPDP)

1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-2-oxo-N-[6-[[1-oxo-3-(2-pyridinyldithio)propyl]amino]hexyl]-, (3aS,4S,6aR)-

Biotin Impurity 31

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(6-(3-(pyridin-2-yldisulfanyl)propanamido)hexyl)pentanamide

Pyridyldisulfide-biotin

Pyridyldithiol-biotin

Biotin HPDP,BiotinHPDP

N-[6-(Biotinamido)hexyl]-3’-(2-pyridyldithio)propionamide

Ciprofibrate Impurity 6

Macamide Impurity 11(Biotin HPDP)

Biotin-HPDP, Sulfhydryl-reactive biotinylation reagent

Biotin-HPDP, 10 mM in DMSO

129179-83-5

C124H37N5O3S3

C24H37N5O3S3

Biotin Derivatives

MTS & Sulfhydryl Active Reagents

BiotinylationReagents