Desmopressin
Description References- Product Name
- Desmopressin
- CAS No.
- 16679-58-6
- Chemical Name
- Desmopressin
- Synonyms
- DDAVP;MINIRIN;esmopressin;DESMOPRESSIN;DDAVP, HUMAN;[deamino-Cys;Desmopressin CRS;DESMOPRESSIN, HUMAN;Iloprost Impurity 8;Desmopressin (DDAVP)
- CBNumber
- CB5487392
- Molecular Formula
- C46H64N14O12S2
- Formula Weight
- 1069.22
- MOL File
- 16679-58-6.mol
Desmopressin Property
- alpha
- D25 +85.5 ± 2° (calculated for the free peptide)
- Density
- 1.56±0.1 g/cm3(Predicted)
- RTECS
- YW9000000
- storage temp.
- Store at 0°C
- solubility
- H2O: soluble20mg/mL, clear, colorless
- pka
- 9.90±0.15(Predicted)
- Water Solubility
- Soluble to 4 mg/ml in water
- InChIKey
- NFLWUMRGJYTJIN-PNIOQBSNSA-N
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- V1005
- Product name
- [deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate
- Purity
- ≥95%(HPLC)
- Packaging
- 0.1mg
- Price
- $80.4
- Updated
- 2024/03/01
- Product number
- V1005
- Product name
- [deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate
- Purity
- ≥95%(HPLC)
- Packaging
- 0.5mg
- Price
- $246
- Updated
- 2024/03/01
- Product number
- J66929
- Product name
- [Deamino-Cys<sup>1</sup>, Arg<sup>8</sup>] Vasopressin
- Packaging
- 1mg
- Price
- $92.7
- Updated
- 2021/12/16
- Product number
- 17348
- Product name
- Desmopressin
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 17348
- Product name
- Desmopressin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $74
- Updated
- 2024/03/01
Desmopressin Chemical Properties,Usage,Production
Description
Desmopressin (Brand name: DDAVP) is an artificial derivative of vasopressin, being similar to the antidiuretic hormone (ADH) that naturally produced in the body. It is used for the treatment of diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease and high blood urea levels. It is capable of increasing the water permeability in the renal tubular cells, further increasing the urine concentration and decreasing the urine production. Therefore, it can be used to prevent and control severe thirst, urination and dehydration caused by various kinds of reasons including injury, surgery and certain medical condition. This help you sleep throughout the night without being awaken by urinate.
References
https://www.drugbank.ca/drugs/DB00035
http://www.medicinenet.com/desmopressin_tabs/article.htm
https://en.wikipedia.org/wiki/Desmopressin
Chemical Properties
White or almost white, fluffy powder.
Originator
DAV,Ritter,Switz.,1974
Uses
Antidiuretic.
Uses
[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate was used to study the impact of vasopressin on pendrin abundance. E3 ubiquitin (Ub)-protein ligases (E3s) was administered in rat kidney and the changes in protein abundance of the selected E3s in response to [deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate was examined.
Definition
ChEBI: A synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. An antidiuretic, it increases urine concentration and decreases urine prod ction, and is used (usually as the trihydrate of the acetic acid salt) to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions. It is also used in the diagnosis and treatment of cranial iabetes insipidus and in tests of renal function.
Manufacturing Process
β-Benzylmercaptopropionyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-Lasparaginyl-S-benzyl-L-cysteinyl-L-prolyl-NG-tosyl-D-arginyl-glycinamide (0.5 g) is reduced with sodium in liquid ammonia. The liquid ammonia is then evaporated and the residue dissolved in 5% aqueous acetic acid (800 ml). The solution is filtered to remove the undissolved portion and the filtrate is adjusted to a pH of 6.5 to 7 by addition of aqueous sodium hydroxide and it is then oxidized by known procedure, cf. Kimbrough, R.D., Jr.; Cash, W.D.; Branda, L.A.; Chan, W.Y.; and Du Vigneaud, V.; J. Biol. Chem. 238,1411 (1963). The reaction mixture is thereupon adjusted to a pH of 4 to 4.5 by addition of acetic acid. The peptide is applied to a column of a carboxylate ion exchange resin, is eluted with 50% aqueous acetic acid and isolated by lyophilization (freeze-drying). The crude product is purified by known procedure using a carrier-free high-voltage electrophoresis, cf. Zaoral, M.; Sorm, F.; Collection Czechoslov. Chem Communs, 31, 310 (1966). Yield, 100 to 200 mg of 1-deamino-8-D-argine-vasopressin.
brand name
Concentraid (Ferring Pharmaceuticals); Ddavp (Sanofi Aventis); Stimate (ZLB Behring).
Therapeutic Function
Antidiuretic
Biochem/physiol Actions
[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate also known as DDAVP, Desmopressin is a selective and potent vasopressor agent that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock. It also stimulate three acid-base transporters and hence increases the capability of the cell to regulate pH.
Clinical Use
Diabetes insipidus
Nocturnal enuresis
Nocturia due to idiopathic nocturnal polyuria
Post-biopsy bleeding (unlicensed indication)
Pre-biopsy prophylaxis (unlicensed indication)
Metabolism
Metabolic fate of desmopressin is unknown. It is not affected by liver microsomal cytochrome P450 enzymes. As a peptide, desmopressin is expected to undergo catabolism to its constituent amino acids, with subsequent recycling of the amino acid in the body pool.
storage
Store at -20°C
Desmopressin Preparation Products And Raw materials
Raw materials
Preparation Products
Desmopressin Suppliers
- Tel
- 0571-89197072; 18668118770
- Fax
- 0571-89197072
- linda@peptide-china.com
- Country
- China
- ProdList
- 248
- Advantage
- 56
- Tel
- 0551-65326643 18156095617
- Fax
- 0551-65326641
- info@cellmano.com
- Country
- China
- ProdList
- 1011
- Advantage
- 55
- Tel
- 0571-86758863 13867485072
- Fax
- 0571-86758863
- lulu@thinheal.com
- Country
- China
- ProdList
- 300
- Advantage
- 58
- Tel
- 0571-88589737 18506821783
- xiaozhi.xu@sinopep.com
- Country
- China
- ProdList
- 87
- Advantage
- 58
- Tel
- 755-755-26612112 15013529272;
- Fax
- +86 (755) 8635-0488
- jymed@jymedtech.com
- Country
- China
- ProdList
- 81
- Advantage
- 58
- Tel
- 18059081430
- 2070812664@qq.com
- Country
- China
- ProdList
- 1232
- Advantage
- 58
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15848
- Advantage
- 69
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 15421
- Advantage
- 60
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12338
- Advantage
- 58
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6181
- Advantage
- 58
- Tel
- 18521735133 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25015
- Advantage
- 65
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3750
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7856
- Advantage
- 58
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3421
- Advantage
- 58
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3123
- Advantage
- 55
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15185
- Advantage
- 58
- Tel
- 86-574-27787657
- Fax
- 86-574-27912196
- info@dearchem.com
- Country
- China
- ProdList
- 4619
- Advantage
- 58
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10287
- Advantage
- 55
- Tel
- 021-64609169 18901607656
- Fax
- 021-64609160
- greensnown@163.com
- Country
- China
- ProdList
- 9911
- Advantage
- 50
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2989
- Advantage
- 60
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9767
- Advantage
- 58
- Tel
- Fax
- -
- xg01_gj@163.com
- Country
- China
- ProdList
- 9503
- Advantage
- 50
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51471
- Advantage
- 80
- Tel
- +86 (531) 8099-2215
- Fax
- +86 (531) 8099-2215
- putubio@outlook.com
- Country
- China
- ProdList
- 1261
- Advantage
- 55
- Tel
- 0571-0571-87157530-8001-8006 18049756717
- Fax
- 0571-87156470
- sales@dingyanchem.com
- Country
- China
- ProdList
- 1997
- Advantage
- 58
- Tel
- 17802107445
- Country
- China
- ProdList
- 185
- Advantage
- 55
- Tel
- 021-52907766-8042
- Fax
- 021-52906523
- Country
- China
- ProdList
- 9947
- Advantage
- 58
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9934
- Advantage
- 55
- Tel
- 025-57798860
- sales@njromanme.com
- Country
- China
- ProdList
- 4534
- Advantage
- 58
- Tel
- 400-1166-196 18502815961
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 14623
- Advantage
- 60
- Tel
- QQ:65489617 15618227136
- Fax
- 21-5161 9052
- info@SuperLan-chem.com
- Country
- China
- ProdList
- 9748
- Advantage
- 58
- Tel
- 021-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
- Country
- China
- ProdList
- 9038
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131981
- Advantage
- 58
- Tel
- 17705183659
- Fax
- 84523390
- sales@njleonbiotech.com
- Country
- China
- ProdList
- 5503
- Advantage
- 55
- Tel
- 18872289958、027-52304252、3400508168
- Fax
- 027-52304252
- 3400508168@qq.com
- Country
- China
- ProdList
- 1910
- Advantage
- 55
- Tel
- 027-027-83778875 15807197853
- Fax
- 027-83991220
- 15807197853@163.com
- Country
- China
- ProdList
- 3977
- Advantage
- 58
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28821
- Advantage
- 58
- Tel
- 028-62328193 17380623303
- Fax
- 028-62328193
- Caroline@youngshechem.com
- Country
- China
- ProdList
- 2353
- Advantage
- 58
- Tel
- 021-60257269 18601606476
- Fax
- +86-21-60253672
- yl@mkpharma.cn
- Country
- China
- ProdList
- 206
- Advantage
- 58
- Tel
- 027-83778895 18602735115
- Fax
- 027-51119224
- 18602735115@163.com
- Country
- China
- ProdList
- 1999
- Advantage
- 64
- Tel
- 021-58111628 15800915896
- Fax
- QQ 3285589261
- Country
- China
- ProdList
- 1988
- Advantage
- 58
- Tel
- 0571-87213919
- Fax
- 0571-87213919
- eric@peptidego.com
- Country
- China
- ProdList
- 6347
- Advantage
- 58
- Tel
- +86-13237129059 +86-13237129059
- Fax
- -
- sales@rixingbiz.com
- Country
- China
- ProdList
- 233
- Advantage
- 58
- Tel
- +86 18516118859
- Fax
- +86 (21) 2096 2272
- sales@chainpeptide.com
- Country
- CHINA
- ProdList
- 420
- Advantage
- 58
- Tel
- Fax
- -
- jnyaoyan@163.com
- Country
- China
- ProdList
- 3069
- Advantage
- 58
- Tel
- +86-0833-2598983 +86-18086877136
- Fax
- +86-833-2598903
- Nyx-peptide@jsjpharm.cn
- Country
- China
- ProdList
- 306
- Advantage
- 58
- Tel
- 027-51831887 15337167856
- Fax
- 027-51837635 QQ1165326703
- hubeixinyuanshun@163.com
- Country
- China
- ProdList
- 10305
- Advantage
- 58
- Tel
- 0371-0371-63315541 13323832564
- Fax
- QQ:3001332135
- 3001332135@qq.com
- Country
- China
- ProdList
- 8800
- Advantage
- 58
- Tel
- 400-400-400-9004166 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52712
- Advantage
- 58
- Tel
- 027-87058617 15872383390
- Fax
- 027-87058617
- hbdibo@163.com
- Country
- China
- ProdList
- 891
- Advantage
- 58
View Lastest Price from Desmopressin manufacturers
- Product
- Desmopressin 16679-58-6
- Price
- US $70.00-700.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-27
- Product
- Desmopressin 16679-58-6
- Price
- US $0.00-0.00/Gram
- Min. Order
- 1Gram
- Purity
- 98%
- Supply Ability
- 50KG
- Release date
- 2024-04-30
- Product
- Desmopressin 16679-58-6
- Price
- US $110.00-90.00/kilograms
- Min. Order
- 1kilograms
- Purity
- 99%
- Supply Ability
- 500tons
- Release date
- 2023-11-27