Desmopressin

Description References

Product Name: Desmopressin
CAS No.: 16679-58-6
Chemical Name: Desmopressin
Synonyms: DDAVP;MINIRIN;esmopressin;DESMOPRESSIN;DDAVP, HUMAN;[deamino-Cys;Desmopressin CRS;DESMOPRESSIN, HUMAN;Iloprost Impurity 8;Desmopressin (DDAVP)
CBNumber: CB5487392
Molecular Formula: C46H64N14O12S2
Formula Weight: 1069.22
MOL File: 16679-58-6.mol

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Desmopressin Property

alpha: D25 +85.5 ± 2° (calculated for the free peptide)
Density: 1.56±0.1 g/cm3(Predicted)
RTECS: YW9000000
storage temp.: Store at 0°C
solubility: H2O: soluble20mg/mL, clear, colorless
pka: 9.90±0.15(Predicted)
form: powder
biological source: synthetic (organic)
Water Solubility: Soluble to 4 mg/ml in water
InChIKey: NFLWUMRGJYTJIN-PNIOQBSNSA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: V1005
Product name: [deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate
Purity: ≥95%(HPLC)
Packaging: 0.1mg
Price: $80.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: V1005
Product name: [deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate
Purity: ≥95%(HPLC)
Packaging: 0.5mg
Price: $246
Updated: 2024/03/01

Alfa Aesar

Product number: J66929
Product name: [Deamino-Cys<sup>1</sup>, Arg<sup>8</sup>] Vasopressin
Packaging: 1mg
Price: $92.7
Updated: 2021/12/16

Cayman Chemical

Product number: 17348
Product name: Desmopressin
Purity: ≥95%
Packaging: 500μg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 17348
Product name: Desmopressin
Purity: ≥95%
Packaging: 1mg
Price: $74
Updated: 2024/03/01

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Desmopressin Chemical Properties,Usage,Production

Description

Desmopressin (Brand name: DDAVP) is an artificial derivative of vasopressin, being similar to the antidiuretic hormone (ADH) that naturally produced in the body. It is used for the treatment of diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease and high blood urea levels. It is capable of increasing the water permeability in the renal tubular cells, further increasing the urine concentration and decreasing the urine production. Therefore, it can be used to prevent and control severe thirst, urination and dehydration caused by various kinds of reasons including injury, surgery and certain medical condition. This help you sleep throughout the night without being awaken by urinate.

References

https://www.drugbank.ca/drugs/DB00035
http://www.medicinenet.com/desmopressin_tabs/article.htm
https://en.wikipedia.org/wiki/Desmopressin

Chemical Properties

White or almost white, fluffy powder.

Originator

DAV,Ritter,Switz.,1974

Uses

Antidiuretic.

Uses

[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate was used to study the impact of vasopressin on pendrin abundance. E3 ubiquitin (Ub)-protein ligases (E3s) was administered in rat kidney and the changes in protein abundance of the selected E3s in response to [deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate was examined.

Definition

ChEBI: A synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. An antidiuretic, it increases urine concentration and decreases urine prod ction, and is used (usually as the trihydrate of the acetic acid salt) to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions. It is also used in the diagnosis and treatment of cranial iabetes insipidus and in tests of renal function.

Manufacturing Process

β-Benzylmercaptopropionyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-Lasparaginyl-S-benzyl-L-cysteinyl-L-prolyl-NG-tosyl-D-arginyl-glycinamide (0.5 g) is reduced with sodium in liquid ammonia. The liquid ammonia is then evaporated and the residue dissolved in 5% aqueous acetic acid (800 ml). The solution is filtered to remove the undissolved portion and the filtrate is adjusted to a pH of 6.5 to 7 by addition of aqueous sodium hydroxide and it is then oxidized by known procedure, cf. Kimbrough, R.D., Jr.; Cash, W.D.; Branda, L.A.; Chan, W.Y.; and Du Vigneaud, V.; J. Biol. Chem. 238,1411 (1963). The reaction mixture is thereupon adjusted to a pH of 4 to 4.5 by addition of acetic acid. The peptide is applied to a column of a carboxylate ion exchange resin, is eluted with 50% aqueous acetic acid and isolated by lyophilization (freeze-drying). The crude product is purified by known procedure using a carrier-free high-voltage electrophoresis, cf. Zaoral, M.; Sorm, F.; Collection Czechoslov. Chem Communs, 31, 310 (1966). Yield, 100 to 200 mg of 1-deamino-8-D-argine-vasopressin.

brand name

Concentraid (Ferring Pharmaceuticals); Ddavp (Sanofi Aventis); Stimate (ZLB Behring).

Therapeutic Function

Antidiuretic

Biochem/physiol Actions

[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate also known as DDAVP, Desmopressin is a selective and potent vasopressor agent that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock. It also stimulate three acid-base transporters and hence increases the capability of the cell to regulate pH.

Clinical Use

Diabetes insipidus
Nocturnal enuresis
Nocturia due to idiopathic nocturnal polyuria
Post-biopsy bleeding (unlicensed indication)
Pre-biopsy prophylaxis (unlicensed indication)

Metabolism

Metabolic fate of desmopressin is unknown. It is not affected by liver microsomal cytochrome P450 enzymes. As a peptide, desmopressin is expected to undergo catabolism to its constituent amino acids, with subsequent recycling of the amino acid in the body pool.

storage

Store at -20°C

Desmopressin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Desmopressin manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: Desmopressin 16679-58-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-05-19

Hangzhou Hyper Chemicals Limited

Product: Desmopressin 16679-58-6
Price: US $0.00-0.00/Gram
Min. Order: 1Gram
Purity: 98%
Supply Ability: 50KG
Release date: 2024-04-30

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Desmopressin 16679-58-6
Price: US $70.00-700.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-27

16679-58-6, DesmopressinRelated Search:

Terlipressin acetate Vasopressin Argipressine DDAVP, Desmopressin,Desmopressin (ADH),DESMOPRESSIN ACETATE SALT,DESMOPRESSIN MONOACETATE,DESMOPRESSIN ACETATE Lixisenatide Angiotensin acetate Teriparatide acetate Pramlintide acetate Teriparatideacetate ARG-LYS-GLU-VAL-TYR ACETATE SALT Secretin Acetate Triptorelin acetate Nafarelin Acetate Ganirelix Leuprorelin acetate Eptifibatide Acetate Eledoisin VAPREOTIDE

MPR-TYR-PHE-GLN-ASN-CYS-PRO-D-ARG-GLY-NH2

MINIRIN

[DEAMINO1, DARG8] VASOPRESSIN

[DEAMINO-CYS1, D-ARG8]-VASOPRESSIN

DDAVP, HUMAN

DESMOPRESSIN

DESMOPRESSIN, HUMAN

DESAMINO-[D-ARG8]VASOPRESSIN

MAP-TYR-PHE-GLN-ASN-CYS-PRO-D-ARG-GLY-NH2

3-MERCAPTOPROPIONYL-TYR-PHE-GLN-ASN-CYS-PRO-D-ARG-GLY-NH2

3-MERCAPTOPROPIONYL-TYR-PHE-GLN-ASN-CYS-PRO-D-ARG-GLY-OH (DISULFIDE BRIDGE: 1-6)

3-MERCAPTOPROPIONYL-YFQNCPRG (DISULFIDE BRIDGE: 1-6)

Vasopressin, 1-(3-mercaptopropanoic acid)-8-D-arginine-

[deamino-cys1, d-arg8]-vasopressin acetate hydrate

DDAVP

3-Mercaptopropionyl-Tyr-Phe-Gln-Asn-Cys-Pro-D-Arg-Gly-NH2 acetate salt (Disulfide bond)

DESMOPRESSIN ACETATE PH. EUR.

M.W. 1069.22 C46H64N14O12S2

1-Desamino-8-D-arginine vasopressin

3-Mercapto(1)propionyl-L-Tyr-L-Phe-L-Gln-L-Asn-L-Cys(1)-L-Pro-D-Arg-Gly-NH2

[Deamino1,DArg8] Vasopressin (dDAVP) Desmopressin

MAP-TYR-PHE-GLN-ASN-CYS-PRO-D-ARG-GLY-NH2(DISULFIDE BRIDGE, MAP1-CYS6)

[deamino-Cys

Desmopresina, Desmopressine, Desmopressinum

(Deamino-Cys1,D-Arg8)-Vasopressin acetate salt 3-Mercaptopropionyl-Tyr-Phe-Gln-Asn-Cys-Pro-D-Arg-Gly-NH2 acetate salt (Disulfide bond)

Desmopressin (DDAVP)

Oxytocin Impurity 13 (Desmopressin)

(Deamino-Cys1,D-Arg?)-Vasopressin

N-[1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[[7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)-

Desmopressin acetate, ≥97.0%(HPLC)

Desmopressin CRS

Glycinamide, N-(3-mercapto-1-oxopropyl)-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-D-arginyl-, cyclic (1→5)-disulfide

esmopressin

Desmopressin USP/EP/BP

Desmopressin-D5 TFAQ: What is Desmopressin-D5 TFA Q: What is the CAS Number of Desmopressin-D5 TFA Q: What is the storage condition of Desmopressin-D5 TFA Q: What are the applications of Desmopressin-D5 TFA

Desmopressin Acetate(net)

(Deamino-Cys?,D-Arg?)-Vasopressin acetate salt

Iloprost Impurity 8

Desmopressin Trifluoroacetate

16679-58-6

C46H64N14O12S2

C46H6N14O12S2

Amino Acid Derivatives

Peptide

Vasopressin and Oxytocin receptor