ChemicalBook > CAS DataBase List > Trimethylamine N-oxide dihydrate
Trimethylamine N-oxide dihydrate
- Product Name
- Trimethylamine N-oxide dihydrate
- CAS No.
- 62637-93-8
- Chemical Name
- Trimethylamine N-oxide dihydrate
- Synonyms
- TMO;Trimethylamine N-Oxide-D9;TRIMETHYLAMINE OXIDE DIHYDRATE;TMANO;amine N-oxide;TMANO Dihydrate;Trimethylamine oxid;amine N-oxide dihydrate;trimethylammoniumoxidhydrat;TriMethylaMine N-Oxide
- CBNumber
- CB5487802
- Molecular Formula
- C3H13NO3
- Formula Weight
- 111.14
- MOL File
- 62637-93-8.mol
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Trimethylamine N-oxide dihydrate Property
- Melting point:
- 95-99 °C(lit.)
- Flash point:
- 95 °C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Sparingly)
- form
- Fine Crystalline Powder
- color
- White to off-white
- Water Solubility
- Soluble in water, ethanol, dimethyl sulfoxide and methanol. Sparingly soluble in hot chloroform. Insoluble in diethyl ether, benzene and hydrocarbon solvents.
- Merck
- 14,9711
- BRN
- 3612927
- InChI
- InChI=1S/C3H9NO.2H2O/c1-4(2,3)5;;/h1-3H3;2*1H2
- InChIKey
- PGFPZGKEDZGJQZ-UHFFFAOYSA-N
- SMILES
- [N+]([O-])(C)(C)C.O.O
- CAS DataBase Reference
- 62637-93-8(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/38-20/21/22
- Safety Statements
- 26-36-37/39
- WGK Germany
- 2
- RTECS
- YH2850000
- F
- 4.10
- TSCA
- Yes
- HS Code
- 29211990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- T0514
- Product name
- Trimethylamine N-oxide dihydrate
- Purity
- 98%
- Packaging
- 100g
- Price
- $211
- Updated
- 2025/07/31
TCI Chemical
- Product number
- T4321
- Product name
- Trimethylamine N-Oxide Dihydrate [for Biochemical Research]
- Packaging
- 5G
- Price
- $84
- Updated
- 2025/07/31
TCI Chemical
- Product number
- T0466
- Product name
- Trimethylamine N-Oxide Dihydrate
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $54
- Updated
- 2025/07/31
TCI Chemical
- Product number
- T4321
- Product name
- Trimethylamine N-Oxide Dihydrate [for Biochemical Research]
- Packaging
- 25G
- Price
- $252
- Updated
- 2025/07/31
TCI Chemical
- Product number
- T0466
- Product name
- Trimethylamine N-Oxide Dihydrate
- Purity
- >98.0%(T)
- Packaging
- 100g
- Price
- $132
- Updated
- 2025/07/31
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Trimethylamine N-oxide dihydrate Chemical Properties,Usage,Production
Chemical Properties
white crystalline powder
Uses
Trimethylamine N-Oxide Dihydrate is as an oxygen transfer agent used to promote heterometallic cluster catalyzing coordinative hydrogenation. Trimethylamine N-Oxide Dihydrate is also used as a catalyst in the preparation of thermally stable TiO2 nanorod incorporated polymers and semiconductor/metal nanocomposites.
Uses
Trimethylamine N-oxide dihydrate is used as an oxidizing agent in organic synthesis. It is also used to make quaternary ammonium compounds and a warning agent for flammable gas. Further, it acts as a flavoring agent or adjuvant. It serves as an oxidant for the catalytic osmium tetraoxide cis-hydroxylation of hindered olefins. In addition to this, it is used as a reactant for C-H bond cleavage and decarbonylating agent for solvent-free reactions.
Uses
Oxidizing reagent in organic synthesis.
General Description
Trimethylamine N-oxide (TMAO) is an amphiphilic osmolyte that can counteract the denaturing effects of urea, pressure, and ice and stabilize the proteins.
reaction suitability
reagent type: oxidant
in vivo
Trimethylamine N-oxide (TMAO) dihydrate contributes to cardiovascular diseases by promoting inflammatory responses. C57BL/6 mice are fed a normal diet, high-choline diet and/or 3-dimethyl-1-butanol (DMB) diet. The levels of Trimethylamine N-oxide dihydrate and choline are increased in choline-fed mice. Left ventricular hypertrophy, pulmonary congestion, and diastolic dysfunction are markedly exacerbated in heart failure with preserved ejection fraction (HFpEF) mice fed high-choline diets compared with mice fed the control diet. Myocardial fibrosis and inflammation were markedly increased in HFpEF mice fed high-choline diets compared with animals fed the control diet[1].
Trimethylamine N-oxide (dihydrate) can be used in animal modeling to construct models of cardiovascular and metabolic diseases[1].
Induction of cardiovascular and metabolic diseases
Background
Trimethylamine N-oxide (dihydrate) stimulated cardiac hypertrophy, as indicated by increased cell area of cardiomyocytes and expression of hypertrophic markers including atrial natriuretic peptide (ANP) and beta-myosin heavy chain (β-MHC). Additionally, Trimethylamine N-oxide (dihydrate) induced cardiac hypertrophy and cardiac fibrosis in SD rats[2].
Specific Mmodeling Methods
Rats: Wistar? male? weighing 200-250 g[1]
Administration: 100 μM and 1 mM? perfusion or incubation in TMAO-containing buffer solution? incubated for 1 h[1]
Mice: CD-1? male? weighing 25-30 g? 6-8 weeks of age[1]
Administration: 120 mg/kg? mixed with drinking water? a single dose or daily for 7 days[1]
Administration: 100 μM and 1 mM? perfusion or incubation in TMAO-containing buffer solution? incubated for 1 h[1]
Mice: CD-1? male? weighing 25-30 g? 6-8 weeks of age[1]
Administration: 120 mg/kg? mixed with drinking water? a single dose or daily for 7 days[1]
Note
(1)Rat hearts were perfused, and aortic rings from each experimental animal were immersed in K+-H+ buffer solution with or without the addition of Trimethylamine N-oxide (dihydrate) (100 μM final concentration). After 1 h of perfusion or incubation, the tissue samples were washed to eliminate the residues of TMAO-containing buffer solution and further homogenized with water in an OMNI Bead Ruptor 24 at a w/v ratio of 1:10[1].
(2)All experimental animals were housed under standard conditions (21-23℃, 12-hour light/dark cycle, relative humidity 45-65%) with unlimited access to food (R70 diet) and water[1].
(3)The mice from the first experimental group received Isoproterenol (HY-B1670A) at a dose of 10 μg/mouse, but the animals from the second group received Isoproterenol (HY-B1670A) and Trimethylamine N-oxide (dihydrate) at doses of 10 μg/mouse and 120 mg/kg, respectively. After 30 min, the experimental animals were anesthetized with isoflurane once more to record the cardiac response to acute cardiac stress and the impact of Trimethylamine N-oxide (dihydrate) on the inotropic and chronotropic effects. For the next seven days, the mice in the second group received Trimethylamine N-oxide (dihydrate) together with drinking water at a dose of 120 mg/kg, while the animals from the first group received pure drinking water[1].
(2)All experimental animals were housed under standard conditions (21-23℃, 12-hour light/dark cycle, relative humidity 45-65%) with unlimited access to food (R70 diet) and water[1].
(3)The mice from the first experimental group received Isoproterenol (HY-B1670A) at a dose of 10 μg/mouse, but the animals from the second group received Isoproterenol (HY-B1670A) and Trimethylamine N-oxide (dihydrate) at doses of 10 μg/mouse and 120 mg/kg, respectively. After 30 min, the experimental animals were anesthetized with isoflurane once more to record the cardiac response to acute cardiac stress and the impact of Trimethylamine N-oxide (dihydrate) on the inotropic and chronotropic effects. For the next seven days, the mice in the second group received Trimethylamine N-oxide (dihydrate) together with drinking water at a dose of 120 mg/kg, while the animals from the first group received pure drinking water[1].
Modeling Indicators
Molecular changes: The addition of 100 μM Trimethylamine N-oxide (dihydrate) to the buffer solution increased the content of Trimethylamine N-oxide (dihydrate) in cardiac tissue by three and in the aortic rings by two points five times[1].
Pathology change: Trimethylamine N-oxide (dihydrate) had no influence on Isoproterenol (HY-B1670A)-induced increase on left ventricular ejection fraction, fractional shortening and heart rate[1].
Histological analysis: Promote myocardial hypertrophy, fibrosis, and inflammation in a model of cardiovascular disease (CVD)[3].
Pathology change: Trimethylamine N-oxide (dihydrate) had no influence on Isoproterenol (HY-B1670A)-induced increase on left ventricular ejection fraction, fractional shortening and heart rate[1].
Histological analysis: Promote myocardial hypertrophy, fibrosis, and inflammation in a model of cardiovascular disease (CVD)[3].
Correlated Product(s):Isoproterenol (HY-B1670A)
3,3-dimethyl-1-butanol (HY-W012977) IC 50
Human Endogenous Metabolite; NLRP3; Microbial Metabolite
Trimethylamine N-oxide dihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Trimethylamine N-oxide dihydrate manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- Trimethylamine N-oxide dihydrate 62637-93-8
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-11
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- Trimethylamine N-oxide dihydrate 62637-93-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-01
Hebei Yanxi Chemical Co., Ltd.
- Product
- Trimethylamine N-oxide dihydrate 62637-93-8
- Price
- US $20.00-10.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2024-03-19
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