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Trimethylamine N-oxide dihydrate

Product Name
Trimethylamine N-oxide dihydrate
CAS No.
62637-93-8
Chemical Name
Trimethylamine N-oxide dihydrate
Synonyms
TMO;Trimethylamine N-Oxide-D9;TRIMETHYLAMINE OXIDE DIHYDRATE;TMANO;amine N-oxide;TMANO Dihydrate;Trimethylamine oxid;amine N-oxide dihydrate;trimethylammoniumoxidhydrat;TriMethylaMine N-Oxide 
CBNumber
CB5487802
Molecular Formula
C3H13NO3
Formula Weight
111.14
MOL File
62637-93-8.mol
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Trimethylamine N-oxide dihydrate Property

Melting point:
95-99 °C(lit.)
Flash point:
95 °C
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Sparingly)
form 
Fine Crystalline Powder
color 
White to off-white
Water Solubility 
Soluble in water, ethanol, dimethyl sulfoxide and methanol. Sparingly soluble in hot chloroform. Insoluble in diethyl ether, benzene and hydrocarbon solvents.
Merck 
14,9711
BRN 
3612927
CAS DataBase Reference
62637-93-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/38-20/21/22
Safety Statements 
26-36-37/39
WGK Germany 
2
RTECS 
YH2850000
F 
4.10
TSCA 
Yes
HS Code 
29211990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T0514
Product name
Trimethylamine N-oxide dihydrate
Purity
98%
Packaging
100g
Price
$205
Updated
2024/03/01
TCI Chemical
Product number
T0466
Product name
Trimethylamine N-Oxide Dihydrate
Purity
>98.0%(T)
Packaging
25g
Price
$54
Updated
2024/03/01
TCI Chemical
Product number
T0466
Product name
Trimethylamine N-Oxide Dihydrate
Purity
>98.0%(T)
Packaging
100g
Price
$132
Updated
2024/03/01
Alfa Aesar
Product number
A14916
Product name
Trimethylamine N-oxide dihydrate
Purity
98+%
Packaging
5g
Price
$37.65
Updated
2024/03/01
Alfa Aesar
Product number
A14916
Product name
Trimethylamine N-oxide dihydrate
Purity
98+%
Packaging
25g
Price
$65
Updated
2024/03/01
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Trimethylamine N-oxide dihydrate Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

Trimethylamine N-Oxide Dihydrate is as an oxygen transfer agent used to promote heterometallic cluster catalyzing coordinative hydrogenation. Trimethylamine N-Oxide Dihydrate is also used as a catalyst in the preparation of thermally stable TiO2 nanorod incorporated polymers and semiconductor/metal nanocomposites.

Uses

Trimethylamine N-oxide dihydrate is used as an oxidizing agent in organic synthesis. It is also used to make quaternary ammonium compounds and a warning agent for flammable gas. Further, it acts as a flavoring agent or adjuvant. It serves as an oxidant for the catalytic osmium tetraoxide cis-hydroxylation of hindered olefins. In addition to this, it is used as a reactant for C-H bond cleavage and decarbonylating agent for solvent-free reactions.

Uses

Oxidizing reagent in organic synthesis.

General Description

Trimethylamine N-oxide (TMAO) is an amphiphilic osmolyte that can counteract the denaturing effects of urea, pressure, and ice and stabilize the proteins.

reaction suitability

reagent type: oxidant

in vivo

Trimethylamine N-oxide (TMAO) dihydrate contributes to cardiovascular diseases by promoting inflammatory responses. C57BL/6 mice are fed a normal diet, high-choline diet and/or 3-dimethyl-1-butanol (DMB) diet. The levels of Trimethylamine N-oxide dihydrate and choline are increased in choline-fed mice. Left ventricular hypertrophy, pulmonary congestion, and diastolic dysfunction are markedly exacerbated in heart failure with preserved ejection fraction (HFpEF) mice fed high-choline diets compared with mice fed the control diet. Myocardial fibrosis and inflammation were markedly increased in HFpEF mice fed high-choline diets compared with animals fed the control diet[1].
Trimethylamine N-oxide (dihydrate) can be used in animal modeling to construct models of cardiovascular and metabolic diseases[1].

Induction of cardiovascular and metabolic diseases
Background
Trimethylamine N-oxide (dihydrate) stimulated cardiac hypertrophy, as indicated by increased cell area of cardiomyocytes and expression of hypertrophic markers including atrial natriuretic peptide (ANP) and beta-myosin heavy chain (β-MHC). Additionally, Trimethylamine N-oxide (dihydrate) induced cardiac hypertrophy and cardiac fibrosis in SD rats[2].
Specific Mmodeling Methods
Rats: Wistar? male? weighing 200-250 g[1]
Administration: 100 μM and 1 mM? perfusion or incubation in TMAO-containing buffer solution? incubated for 1 h[1]
Mice: CD-1? male? weighing 25-30 g? 6-8 weeks of age[1]
Administration: 120 mg/kg? mixed with drinking water? a single dose or daily for 7 days[1]
Note
(1)Rat hearts were perfused, and aortic rings from each experimental animal were immersed in K+-H+ buffer solution with or without the addition of Trimethylamine N-oxide (dihydrate) (100 μM final concentration). After 1 h of perfusion or incubation, the tissue samples were washed to eliminate the residues of TMAO-containing buffer solution and further homogenized with water in an OMNI Bead Ruptor 24 at a w/v ratio of 1:10[1].
(2)All experimental animals were housed under standard conditions (21-23℃, 12-hour light/dark cycle, relative humidity 45-65%) with unlimited access to food (R70 diet) and water[1].
(3)The mice from the first experimental group received Isoproterenol (HY-B1670A) at a dose of 10 μg/mouse, but the animals from the second group received Isoproterenol (HY-B1670A) and Trimethylamine N-oxide (dihydrate) at doses of 10 μg/mouse and 120 mg/kg, respectively. After 30 min, the experimental animals were anesthetized with isoflurane once more to record the cardiac response to acute cardiac stress and the impact of Trimethylamine N-oxide (dihydrate) on the inotropic and chronotropic effects. For the next seven days, the mice in the second group received Trimethylamine N-oxide (dihydrate) together with drinking water at a dose of 120 mg/kg, while the animals from the first group received pure drinking water[1].
Modeling Indicators
Molecular changes: The addition of 100 μM Trimethylamine N-oxide (dihydrate) to the buffer solution increased the content of Trimethylamine N-oxide (dihydrate) in cardiac tissue by three and in the aortic rings by two points five times[1].
Pathology change: Trimethylamine N-oxide (dihydrate) had no influence on Isoproterenol (HY-B1670A)-induced increase on left ventricular ejection fraction, fractional shortening and heart rate[1].
Histological analysis: Promote myocardial hypertrophy, fibrosis, and inflammation in a model of cardiovascular disease (CVD)[3].
Correlated Product(s):Isoproterenol (HY-B1670A)
3,3-dimethyl-1-butanol (HY-W012977)

IC 50

Human Endogenous Metabolite; NLRP3; Microbial Metabolite

Trimethylamine N-oxide dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Trimethylamine N-oxide dihydrate Suppliers

Belgium 1 Canada 1 China 204 Europe 1 Germany 2 India 5 Japan 2 Poland 1 Switzerland 2 United Kingdom 7 United States 27 Global 253
TCI Chemicals (India) Pvt. Ltd.
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Alfa Aesar
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A.J Chemicals
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CHEMSWORTH
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View Lastest Price from Trimethylamine N-oxide dihydrate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Trimethylamine N-oxide dihydrate 62637-93-8
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 mt
Release date
2024-11-11
Hebei Chuanghai Biotechnology Co., Ltd
Product
Trimethylamine N-oxide dihydrate 62637-93-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-01
Hebei Mujin Biotechnology Co.,Ltd
Product
Trimethylamine N-oxide dihydrate 62637-93-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-25

62637-93-8, Trimethylamine N-oxide dihydrateRelated Search:

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  • methanamineoxide,n,n-dimethyl,dihydrate
  • n,n-dimethylmethanamineoxide,dihydrate
  • trimethylammoniumoxidhydrat
  • TMO
  • TRIMETHYLAMINE N-OXIDE DIHYDRATE
  • TRIMETHYLAMINE OXIDE DIHYDRATE
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  • TrimethylamineN-oxidedihydrate,98%
  • TRIMETHYLAMINE N-OXIDE DIHYDRA
  • Trimethylamine N-Oxide-D9
  • Methanamine, N,N-dimethyl-, N-oxide, dihydrate
  • Trimethylamine-N-oxide 2-hydrate
  • TMANO Dihydrate
  • Trimethylamine-N-oxide dihydrate 1g [62637-93-8]
  • TriMethylaMine N-oxide dihydrate, 98% 25GR
  • N,N-DiMethylMethanaMine N-Oxide Dihydrate
  • TriMethylaMine N-Oxide&nbsp
  • Trimethylamine N-oxide dihydrate,TMANO
  • TriMethylaMine N-oxide dihydrate puruM, >=99.0% (NT)
  • Trimethylamine <i>N</i>-Oxide Dihydrate
  • amine N-oxide dihydrate
  • Trimethylamine N-oxide dihydrate, 98%, for synthesis
  • amine N-oxide
  • Trimethylamine N-oxide dihydrate ISO 9001：2015 REACH
  • Trimethylamine oxid
  • Trimetlylamine oxide, dihydrate
  • Methanamine, N,N-dimethyl-, N-oxide, dihydrate (9CI)
  • 62637-93-8
  • C3H9NOx2H2O
  • C3H13NO3
  • C3H9NO2H2O
  • Oxidation
  • Others
  • Synthetic Reagents
  • Amines
  • Catalyst
  • Oxidation
  • Synthetic Organic Chemistry
  • bc0001