ChemicalBook > CAS DataBase List > 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one

5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one

Product Name: 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one
CAS No.: 885-70-1
Chemical Name: 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one
Synonyms: 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one;LS 75;Pirenzepine EP Impurity B;11H-Pyrido[2,3-b][1,4]benzodiazepine-6(5H)-one;5H-BENZO[E]PYRIDO[3,2-B][1,4]DIAZEPIN-6(11H)-ONE;5,11-dihydropyrido[2,3-b][1,4]benzodiazepin-6-one;1,5-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one;5,6-Dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine;6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one,5,11-dihydro-;6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 1,5-dihydro-
CBNumber: CB5488339
Molecular Formula: C12H9N3O
Formula Weight: 211.22
MOL File: 885-70-1.mol

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5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one Property

Melting point:: 292-293℃
Boiling point:: 336℃
Density: 1.275
Flash point:: 157℃
storage temp.: Refrigerator, under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 11.58±0.20(Predicted)
color: Light Beige to Beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D446720
Product name: 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Packaging: 2.5g
Price: $105
Updated: 2021/12/16

Matrix Scientific

Product number: 070862
Product name: 5,6-Dihydro-6-oxo-11H-pyrido-[2,3-b][1,4]benzodiazepine
Purity: 98%
Packaging: 25g
Price: $208
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0165648
Product name: 5,11-DIHYDROPYRIDO[2,3-BETA][1,4]BENZODIAZEPIN-6-ONE
Purity: 95.00%
Packaging: 25G
Price: $1268.19
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0165648
Product name: 5,11-DIHYDROPYRIDO[2,3-BETA][1,4]BENZODIAZEPIN-6-ONE
Purity: 95.00%
Packaging: 5L
Price: $6462.5
Updated: 2021/12/16

Matrix Scientific

Product number: 070862
Product name: 5,6-Dihydro-6-oxo-11H-pyrido-[2,3-b][1,4]benzodiazepine
Purity: 98%
Packaging: 1g
Price: $30
Updated: 2021/12/16

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5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one Chemical Properties,Usage,Production

Chemical Properties

Light yellow crystals. Melting point 283-285℃ (286-288℃).

Uses

5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one, can be used in the synthesis of fluorescent pirenzepine derivatives, used as potential bitopic ligands of the Human M1 Muscarinic receptor.

Synthesis

In a 1000 ml reaction flask,Add 600 ml of butanol,100 g of 2-amino-N- (2-chloropyridyl-3-yl) benzamide,2 ml of concentrated sulfuric acid,The reaction was refluxed for 3 hours at a reaction temperature of 80 ?? C,Cooled to room temperature,filter,Washed with acetone,50-60 ?? C in vacuo to give 98 g of a pale yellow solid product,Yield 98percent, purity 99percent.

References

[1] Patent: CN106432227, 2017, A. Location in patent: Paragraph 0019; 0020
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 17, p. 4300 - 4315
[3] Journal of Medicinal Chemistry, 1993, vol. 36, # 15, p. 2107 - 2114
[4] Collection of Czechoslovak Chemical Communications, 1988, vol. 53, # 8, p. 1820 - 1844
[5] Patent: WO2006/8118, 2006, A1. Location in patent: Page/Page column 20

5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one Preparation Products And Raw materials

Raw materials

Stannous chloride dihydrate N-(2-CHLOROPYRIDIN-3-YL)-2-NITROBENZAMIDE 2-Chloro-3-pyridinamine 2-Nitrobenzoyl chloride

Preparation Products

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View Lastest Price from 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one manufacturers

Career Henan Chemical Co

Product: 2-CHLORO-4-FLUORO-5-METHYL ANILINE 116759-33-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-14

Career Henan Chemical Co

Product: 5H-BENZO[E]PYRIDO[3,2-B][1,4]DIAZEPIN-6(11H)-ONE 885-70-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-14

885-70-1, 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-oneRelated Search:

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE BIBN 99 5,11-Dihydro-11-chloroacetyl-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one Pirenzepine AF-DX 384 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-(1H-imidazol -1-ylacetyl)-, hydrate Pirenzepine hydrochloride tripitramine 11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE PIRENZEPINE, [N-METHYL-3H]- AF-DX 384, [2,3-DIPROPYLAMINO-3H]-

5H-BENZO[E]PYRIDO[3,2-B][1,4]DIAZEPIN-6(11H)-ONE

5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

LS 75

11H-Pyrido[2,3-b][1,4]benzodiazepine-6(5H)-one

5,11-dihydropyrido[2,3-b][1,4]benzodiazepin-6-one

5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one AK-36728

6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 1,5-dihydro-

6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one,5,11-dihydro-

1,5-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

5,6-Dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine

Pirenzepine EP Impurity B

885-70-1