(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT

Product Name: (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT
CAS No.: 60-99-1
Chemical Name: (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT
Synonyms: XP 03;rp7044;C07192;Nirvan;skf5116;Sinogan;cl36467;cl39743;cl53212;dedoran
CBNumber: CB5488571
Molecular Formula: C19H24N2OS
Formula Weight: 328.47
MOL File: 60-99-1.mol

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(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Property

Melting point:: 117°C
Boiling point:: 468.0±45.0 °C(Predicted)
Density: 1.0897 (rough estimate)
refractive index: 1.5950 (estimate)
storage temp.: Store at -20°C
solubility: Chloroform (Slightly), Methanol (Very Slightly)
form: Solid
pka: 9.32±0.28(Predicted)
color: White to Off-White
Water Solubility: 20mg/L(25 ºC)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36
RIDADR: 3249
RTECS: SO6125000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 2934302300
Toxicity: LD50 oral in rat: 1100mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1415006
Product name: Methotrimeprazine maleate salt
Packaging: 200mg
Price: $276
Updated: 2024/03/01

TRC

Product number: M260770
Product name: (R)-Methotrimeprazine
Packaging: 10mg
Price: $1470
Updated: 2021/12/16

ChemScene

Product number: CS-0013678
Product name: Levomepromazine
Purity: 99.98%
Packaging: 10mg
Price: $85
Updated: 2021/12/16

ChemScene

Product number: CS-0013678
Product name: Levomepromazine
Purity: 99.98%
Packaging: 50mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0013678
Product name: Levomepromazine
Purity: 99.98%
Packaging: 100mg
Price: $420
Updated: 2021/12/16

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(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Chemical Properties,Usage,Production

Originator

Levoprome ,Lederle,US,1966

Uses

(R)-Methotrimeprazine acts as an analgesic agent.

Definition

ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine substituted by a (2R)-3-(dimethylamino)-2-methylpropyl group and a methoxy group at positions 10 and 2 respectively.

Manufacturing Process

95% sodamide (2.33 g) is added to a boiling solution of 3- methoxyphenthiazine (12 g) in anhydrous xylene (150 cc) and the mixture is heated with agitation under reflux for 1? hours. A solution of 1- dimethylamino-2-methyl-3-chloropropane (8.2 g) in anhydrous xylene (90 cc) is then run in over a period of 45 minutes while the reaction temperature is maintained and heating under reflux is continued for 18 hours.
After cooling, the reaction mixture is agitated with a mixture of water (40 cc) and a normal solution of methanesulfonic acid (70 cc), the xylene layer is removed and the acid liquors are washed with ether (200 cc). The aqueous phase is then made alkaline with sodium hydroxide (d = 1.33; 10 cc) and the liberated base is extracted with ether. The ethereal solution is dried over anhydrous potassium carbonate and concentrated at normal pressure. On distillation of the residue under reduced pressure 3-(3-methoxy-10- phenthiazinyl)-2-methyl-1-dimethylaminopropane (11.3 g) is obtained, MP 103°C, BP 182° to 191°C/0.15 mm Hg. The hydrochloride prepared in isopropanol melts at about 90°C.

brand name

Levoprome (Immunex).

Therapeutic Function

Analgesic

(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Suppliers

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View Lastest Price from (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT manufacturers

Xiamen Wonderful Bio Technology Co., Ltd.

Product: Levomepromazine 60-99-1
Price: US $66.00/kg
Min. Order: 1kg
Purity: 99.98%
Supply Ability: 1
Release date: 2023-06-08

60-99-1, (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALTRelated Search:

2-Methoxyphenothiazine Phenothiazine (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Methotrimeprazine Sulfoxide

methotrimeprazine maleate

rp7044

Sinogan

Sinogan-Debil

SK&F 5116

SKF 5116

skf5116

Tisercin

Veractil

(bR)-2-Methoxy-N,N,b-trimethyl-10H-phenothiazine-10-propanamine

Levoprom

10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,.beta.-trimethyl-, (.beta.R)-

10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,b-trimethyl-, (bR)- (9CI)

10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,b-trimethyl-, (R)-

NSC 226516

Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-2-methoxy-, (-)- (8CI)

XP 03

(R)-2-Methoxy-N,N,-trimethyl-10H-phenothiazine-10-propanamine

C07192

Methotrimeprazine-d3 maleate

Methotrimeprazine (200 mg)

10H-Phenothiazine-10-propanaMine, 2-Methoxy-N,N,β-triMethyl-, (βR)-

(2R)-3-(2-methoxyphenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine

(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT

METHOTRIMEPRAZINE MALEATE SALT

(-)-10-(3-(Dimethylamino)-2-methylpropyl)-2-methoxyphenothiazine

(-)-3-(2-Methoxyphenothiazin-10-yl)-2-methylpropyldimethylamine

(-)-phenothiazin

10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,beta-trimethyl-, (-)-

10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,beta-trimethyl-, (R)-

2-Methoxytrimeprazine

3-(2-Methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethyl-1-propanamine

7044 R.P.

arc-vi-c-5

bayer1213

CL 36467

CL 39743

cl36467

cl39743

cl53212

dedoran

Hirnamin

hirnamine

Levomeprazine

Levomepromazin

Levomepromazine

Levomepropazine

Levopromazine

levopromazioni

Levoprome

Levopromethazine

Levotomin

Mepromazine

methotrimeprazine

methoxytrimeprazine

milezin

minozinan

n,beta-trimethyl-2-methoxy-(r)-10h-phenothiazine-10-propanamin