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Chlorguanide Hydrochloride

Product Name
Chlorguanide Hydrochloride
CAS No.
637-32-1
Chemical Name
Chlorguanide Hydrochloride
Synonyms
m4888;3359rp;diguanyl;Paludrin;sn12,837;Chlorguanid;Chloroquanil;Proguanil HCL;ChlorguanideHCl;PROGUANIL HCL IP/BP
CBNumber
CB5488955
Molecular Formula
C11H17Cl2N5
Formula Weight
290.19
MOL File
637-32-1.mol
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Chlorguanide Hydrochloride Property

Melting point:
249-2510C
storage temp. 
2-8°C
solubility 
acetonitrile: water: ~1mg/mL (60/40)
form 
solid
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
3249
WGK Germany 
3
RTECS 
DU1750000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2925294500
Toxicity
LD50 orally in rats: 200 mg/kg (Schmidt)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G7048
Product name
Proguanil hydrochloride
Purity
≥95% (HPLC)
Packaging
10mg
Price
$90
Updated
2024/03/01
Sigma-Aldrich
Product number
1568040
Product name
Proguanil hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$393
Updated
2024/03/01
Sigma-Aldrich
Product number
BP297
Product name
Proguanil hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$221
Updated
2023/06/20
Sigma-Aldrich
Product number
PHR1713
Product name
Proguanil hydrochloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
G7048
Product name
Proguanil hydrochloride
Purity
≥95% (HPLC)
Packaging
50mg
Price
$341
Updated
2024/03/01
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Chlorguanide Hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug.

Uses

Chlorguanide Hydrochloride can be intended for use as an internal standard for the quantification of Proguanil by GC- or LC-mass spectrometry.

brand name

Paludrine (Zeneca).

General Description

Proguanil hydrochloride is a biguanide compound, widely used as an antimalarial drug. It exhibits sporontocidal activity, thereby rendering the gametocytes non-infective to the mosquito vector.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biochem/physiol Actions

Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.

Chlorguanide Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Chlorguanide Hydrochloride Suppliers

Canada 4 China 46 Europe 2 France 2 Germany 1 India 42 Israel 1 Norway 1 Philippines 1 Poland 1 Switzerland 1 United Arab Emirates 1 United Kingdom 7 United States 14 Global 124
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8073
Advantage
58
Jinan Mingya Medical Technology Co., Ltd.
Tel
0531-85828981
Fax
+86-531-85806006
Email
864598798@qq.com
Country
China
ProdList
588
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3420
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17982
Advantage
56
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Nanjing XiZe Biotechnology CO., Ltd.
Tel
025-58362220 15250997978
Fax
025-58362220
Email
1511893459@qq.com
Country
China
ProdList
7715
Advantage
55
Alfa Chemistry
Tel
1-516-6625404
Fax
1-516-927-0118
Email
support@alfa-chemistry.com
Country
United States
ProdList
9171
Advantage
60
Clearsynth Canada Inc.
Tel
+1.415.685.4395
Fax
+1.415.685.4395
Email
enquiry@clearsynth.com
Country
Canada
ProdList
912
Advantage
58
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View Lastest Price from Chlorguanide Hydrochloride manufacturers

Dideu Industries Group Limited
Product
Chlorguanide Hydrochloride 637-32-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-17

637-32-1, Chlorguanide HydrochlorideRelated Search:

Proguanil Related Compound D (25 mg) (1,5-bis(1-methylethyl)biguanide hydrochloride) 1-(3-Chlorophenyl)-5-isopropylbiguanide Hydrochloride Proguanil Related Compound C (25 mg) (1,5-bis(4-chlorophenyl)biguanide hydrochloride) 1-Cyano-3-isopropylguanidine Levetiracetam Gemfibrozil GEMFIBROZIL RELATED COMPOUND A (20 MG) (2,2-DIMETHYL-5-[2,5-DIMETHYL-4-(PROPENE-1-YL)PHE-NOXY]VALERIC ACID) PROGUANIL HYDROCHLORIDE - REFERENCE SPECTRUM PROGUANIL HYDROCHLORIDE IMP. B (EP): 4-CHLOROANILINE GEMFIBROZIL IMPURITY A PROGUANIL HYDROCHLORIDE 1-(4-CHLOROPHENYL)BIGUANIDE HYDROCHLORIDE N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE Chlorguanide Hydrochloride

  • 1-(p-chlorophenyl)-5-isopropylbiguanidehydrochloride
  • N1-(4-Chlorophenyl)-N5-isopropylbiguanide Hydrochloride
  • 1-(p-chlorophenyl)-5-isopropyl-biguanidmonohydrochloride
  • 3359rp
  • chlorguanidehydrochloride
  • chloroguanidehydrochloride
  • chloroguanidinehydrochloride
  • diguanyl
  • drinupalhydrochloride
  • Chlorguanid
  • N-(4-Chlorophenyl)-N'-(1-methylethyl)-imidodicarbonimidic Diamide Hydrochloride
  • Paludrin
  • Chlorguanide Hydrochloride3
  • N1-(4-Chlorophenyl)-N5-isopropylbiguanide
  • PROGUANIL HYDROCHLORIDE###N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE
  • guanatolhydrochloride
  • m4888
  • n-4-chlorophenyl-n(sup5)-isopropyldiguanidehydrochloride
  • paludrinehydrochloride
  • palusilhydrochloride
  • sn12,837
  • PROGUANIL HYDROCHLORIDE
  • Biguanide, 1-(p-chlorophenyl)-5-isopropyl-, monohydrochloride
  • Chloroquanil
  • Proguanil Hydrochloride (200 mg)
  • IMidodicarboniMidic diaMide, N-(4-chlorophenyl)-N'-(1-Methylethyl) -, Hydrochloride (1:1)
  • Proguanil HCL
  • ChlorguanideHCl
  • Proguanil for system suitability
  • 1-(4-Chlorophenyl)-5-(1-methylethyl)biguanide hydrochloride
  • Chlorguanide Hydrochloride USP/EP/BP
  • Proguanil Hydrochloride (1568040)
  • Proguanil hydrochloride,Proguanil,infection,biguanide,Inhibitor,embryotoxicity,toxicity,inhibit,Parasite,reproductive,antimalarial,Antifolate
  • Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-,monohydrochloride
  • PROGUANIL HCL IP/BP
  • 637-32-1
  • C11H16ClN5HCl
  • C11H17Cl2N5
  • Aromatics
  • Bases & Related Reagents
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
  • PALUDRINE