ChemicalBook > CAS DataBase List > Chlorguanide Hydrochloride

Chlorguanide Hydrochloride

Product Name
Chlorguanide Hydrochloride
CAS No.
637-32-1
Chemical Name
Chlorguanide Hydrochloride
Synonyms
m4888;3359rp;diguanyl;Paludrin;sn12,837;Chlorguanid;Chloroquanil;Proguanil HCL;ChlorguanideHCl;PROGUANIL HCL IP/BP
CBNumber
CB5488955
Molecular Formula
C11H17Cl2N5
Formula Weight
290.19
MOL File
637-32-1.mol
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Chlorguanide Hydrochloride Property

Melting point:
249-2510C
storage temp. 
2-8°C
solubility 
acetonitrile: water: ~1mg/mL (60/40)
form 
solid
Water Solubility 
acetonitrile: water: ~1mg/mL (60/40)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
3249
WGK Germany 
3
RTECS 
DU1750000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2925294500
Toxicity
LD50 orally in rats: 200 mg/kg (Schmidt)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G7048
Product name
Proguanil hydrochloride
Purity
≥95% (HPLC)
Packaging
10mg
Price
$90
Updated
2024/03/01
Sigma-Aldrich
Product number
1568040
Product name
Proguanil hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$393
Updated
2024/03/01
Sigma-Aldrich
Product number
BP297
Product name
Proguanil hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$221
Updated
2023/06/20
Sigma-Aldrich
Product number
PHR1713
Product name
Proguanil hydrochloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
G7048
Product name
Proguanil hydrochloride
Purity
≥95% (HPLC)
Packaging
50mg
Price
$341
Updated
2024/03/01
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Chlorguanide Hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug.

Uses

Chlorguanide Hydrochloride can be intended for use as an internal standard for the quantification of Proguanil by GC- or LC-mass spectrometry.

brand name

Paludrine (Zeneca).

General Description

Proguanil hydrochloride is a biguanide compound, widely used as an antimalarial drug. It exhibits sporontocidal activity, thereby rendering the gametocytes non-infective to the mosquito vector.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biochem/physiol Actions

Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.

Chlorguanide Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Chlorguanide Hydrochloride manufacturers

Dideu Industries Group Limited
Product
Chlorguanide Hydrochloride 637-32-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-17

637-32-1, Chlorguanide HydrochlorideRelated Search:

Proguanil Related Compound D (25 mg) (1,5-bis(1-methylethyl)biguanide hydrochloride) 1-(3-Chlorophenyl)-5-isopropylbiguanide Hydrochloride Proguanil Related Compound C (25 mg) (1,5-bis(4-chlorophenyl)biguanide hydrochloride) 1-Cyano-3-isopropylguanidine Levetiracetam Gemfibrozil GEMFIBROZIL RELATED COMPOUND A (20 MG) (2,2-DIMETHYL-5-[2,5-DIMETHYL-4-(PROPENE-1-YL)PHE-NOXY]VALERIC ACID) PROGUANIL HYDROCHLORIDE - REFERENCE SPECTRUM PROGUANIL HYDROCHLORIDE IMP. B (EP): 4-CHLOROANILINE GEMFIBROZIL IMPURITY A PROGUANIL HYDROCHLORIDE 1-(4-CHLOROPHENYL)BIGUANIDE HYDROCHLORIDE N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE Chlorguanide Hydrochloride

  • 1-(p-chlorophenyl)-5-isopropylbiguanidehydrochloride
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  • N1-(4-Chlorophenyl)-N5-isopropylbiguanide
  • PROGUANIL HYDROCHLORIDE###N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE
  • guanatolhydrochloride
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  • PROGUANIL HYDROCHLORIDE
  • Biguanide, 1-(p-chlorophenyl)-5-isopropyl-, monohydrochloride
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  • Proguanil Hydrochloride (200 mg)
  • IMidodicarboniMidic diaMide, N-(4-chlorophenyl)-N'-(1-Methylethyl) -, Hydrochloride (1:1)
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  • Chlorguanide Hydrochloride USP/EP/BP
  • Proguanil Hydrochloride (1568040)
  • Proguanil hydrochloride,Proguanil,infection,biguanide,Inhibitor,embryotoxicity,toxicity,inhibit,Parasite,reproductive,antimalarial,Antifolate
  • Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-,monohydrochloride
  • PROGUANIL HCL IP/BP
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  • C11H17Cl2N5
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