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PROGUANIL HYDROCHLORIDE

Product Name
PROGUANIL HYDROCHLORIDE
CAS No.
537-21-3
Chemical Name
PROGUANIL HYDROCHLORIDE
Synonyms
M-5943;chlorproguanil;Chloroproguanil;PROGUANIL HYDROCHLORIDE;N1-3,4-Dichlorophenyl-N5-isopropyldiguanide;1-(3,4-Dichlorophenyl)-5-isopropylbiguanide;N-(3,4-Dichlorophenyl)-N'-isopropyldicarbonimido/ic diamide/imido;N-(3,4-Dichlorophenyl)-N'-(1-Methylethyl)iMidodicarboniMidic DiaMide;(1E)-1-[amino-(3,4-dichloroanilino)methylidene]-2-propan-2-ylguanidine;Imidodicarbonimidic diamide, N-(3,4-dichlorophenyl)-N'-(1-methylethyl)-
CBNumber
CB2488954
Molecular Formula
C11H15Cl2N5
Formula Weight
288.18
MOL File
537-21-3.mol
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PROGUANIL HYDROCHLORIDE Property

Melting point:
120-121 °C
Boiling point:
350.7±52.0 °C(Predicted)
Density 
1.40±0.1 g/cm3(Predicted)
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
10.77±0.10(Predicted)
color 
White to Off-White
BCS Class
1
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0009147
Product name
CHLORPROGUANIL
Purity
95.00%
Packaging
50MG
Price
$750.75
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009147
Product name
CHLORPROGUANIL
Purity
95.00%
Packaging
500MG
Price
$1963.5
Updated
2021/12/16
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PROGUANIL HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

PROGUANIL HYDROCHLORIDE is an antimalarial agent used in combination with Dapsone (D193250).

Definition

ChEBI: Chlorproguanil is a dichlorobenzene.

Clinical Use

Malaria chemoprophylaxis

Drug interactions

Potentially hazardous interactions with other drugs
Anticoagulants: effect of warfarin possibly enhanced.
Antimalarials: avoid concomitant use with artemether/lumefantrine; increased antifolate effect with pyrimethamine.

Metabolism

Proguanil is metabolised in the liver to the active metabolite, cycloguanil, and to p-chlorophenylbiguanide which is inactive, mainly by cytochrome P450, CYP 2C19 and slightly by CYP 3A4. Unlike proguanil and p-chlorophenylbiguanide, cycloguanil is not concentrated in erythrocytes so concentrations of cycloguanil in plasma and whole blood are similar. About 40-60% of a dose of proguanil is excreted in the urine, 60% of this as the unchanged drug, 30% as cycloguanil, and 8% as p-chlorophenylbiguanide. About 10% of a dose is excreted in the faeces.

PROGUANIL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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PROGUANIL HYDROCHLORIDE Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15421
Advantage
60
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 13028896684
Email
sales@rrkchem.com
Country
China
ProdList
55477
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44941
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-81124267 15229202216
Fax
029-88380327
Email
1073@dideu.com
Country
China
ProdList
10011
Advantage
58
Hebei Zhenjia new material Co., LTD
Tel
0319-5925599 13315915972
Email
13313090628@163.com
Country
China
ProdList
3491
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40036
Advantage
58
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Email
SY06@accelachem.com
Country
China
ProdList
10334
Advantage
58
Hebei Zhentian food additives Co., LTD
Tel
0319-5925599 13373390591
Email
13373390591@163.com
Country
China
ProdList
11447
Advantage
58
Shaanxi Didu New Materials Co. Ltd
Tel
+86-89586680 +86-13289823923
Email
1026@dideu.com
Country
China
ProdList
9602
Advantage
58

537-21-3, PROGUANIL HYDROCHLORIDERelated Search:


  • PROGUANIL HYDROCHLORIDE
  • (1E)-1-[amino-(3,4-dichloroanilino)methylidene]-2-propan-2-ylguanidine
  • 1-carbamimidoyl-1-(3,4-dichlorophenyl)-2-propan-2-yl-guanidine hydroch loride
  • N-(3,4-Dichlorophenyl)-N'-(1-Methylethyl)iMidodicarboniMidic DiaMide
  • N1-3,4-Dichlorophenyl-N5-isopropyldiguanide
  • Chloroproguanil
  • 1-(3,4-Dichlorophenyl)-5-isopropylbiguanide
  • Imidodicarbonimidic diamide, N-(3,4-dichlorophenyl)-N'-(1-methylethyl)-
  • M-5943
  • N-(3,4-Dichlorophenyl)-N'-isopropyldicarbonimido/ic diamide/imido
  • chlorproguanil
  • 537-21-3
  • C11H16Cl3N5
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals