PROGUANIL HYDROCHLORIDE

Product Name: PROGUANIL HYDROCHLORIDE
CAS No.: 537-21-3
Chemical Name: PROGUANIL HYDROCHLORIDE
Synonyms: M-5943;chlorproguanil;Chloroproguanil;PROGUANIL HYDROCHLORIDE;N1-3,4-Dichlorophenyl-N5-isopropyldiguanide;1-(3,4-Dichlorophenyl)-5-isopropylbiguanide;N-(3,4-Dichlorophenyl)-N'-isopropyldicarbonimido/ic diamide/imido;N-(3,4-Dichlorophenyl)-N'-(1-Methylethyl)iMidodicarboniMidic DiaMide;(1E)-1-[amino-(3,4-dichloroanilino)methylidene]-2-propan-2-ylguanidine;Imidodicarbonimidic diamide, N-(3,4-dichlorophenyl)-N'-(1-methylethyl)-
CBNumber: CB2488954
Molecular Formula: C11H15Cl2N5
Formula Weight: 288.18
MOL File: 537-21-3.mol

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PROGUANIL HYDROCHLORIDE Property

Melting point:: 120-121 °C
Boiling point:: 350.7±52.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 10.77±0.10(Predicted)
color: White to Off-White
BCS Class: 1
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0009147
Product name: CHLORPROGUANIL
Purity: 95.00%
Packaging: 50MG
Price: $750.75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009147
Product name: CHLORPROGUANIL
Purity: 95.00%
Packaging: 500MG
Price: $1963.5
Updated: 2021/12/16

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PROGUANIL HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

PROGUANIL HYDROCHLORIDE is an antimalarial agent used in combination with Dapsone (D193250).

Definition

ChEBI: Chlorproguanil is a dichlorobenzene.

Clinical Use

Malaria chemoprophylaxis

Drug interactions

Potentially hazardous interactions with other drugs
Anticoagulants: effect of warfarin possibly enhanced.
Antimalarials: avoid concomitant use with artemether/lumefantrine; increased antifolate effect with pyrimethamine.

Metabolism

Proguanil is metabolised in the liver to the active metabolite, cycloguanil, and to p-chlorophenylbiguanide which is inactive, mainly by cytochrome P450, CYP 2C19 and slightly by CYP 3A4. Unlike proguanil and p-chlorophenylbiguanide, cycloguanil is not concentrated in erythrocytes so concentrations of cycloguanil in plasma and whole blood are similar. About 40-60% of a dose of proguanil is excreted in the urine, 60% of this as the unchanged drug, 30% as cycloguanil, and 8% as p-chlorophenylbiguanide. About 10% of a dose is excreted in the faeces.

PROGUANIL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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PROGUANIL HYDROCHLORIDE Suppliers

Canada 1 China 15 India 2 United Kingdom 1 United States 1 Global 20

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537-21-3, PROGUANIL HYDROCHLORIDERelated Search:

Verapamil N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE 1-(4-CHLOROPHENYL)BIGUANIDE HYDROCHLORIDE 3-Chlorophenylguanidine 1-(3-CHLOROPHENYL)BIGUANIDE HYDROCHLORIDE 4-CHLOROPHENYLGUANIDINE HYDROCHLORIDE Chlorguanide Hydrochloride N-(3,4-Dichlorophenyl)guanidine PROGUANIL HYDROCHLORIDE

PROGUANIL HYDROCHLORIDE

(1E)-1-[amino-(3,4-dichloroanilino)methylidene]-2-propan-2-ylguanidine

1-carbamimidoyl-1-(3,4-dichlorophenyl)-2-propan-2-yl-guanidine hydroch loride

N-(3,4-Dichlorophenyl)-N'-(1-Methylethyl)iMidodicarboniMidic DiaMide

N1-3,4-Dichlorophenyl-N5-isopropyldiguanide

Chloroproguanil

1-(3,4-Dichlorophenyl)-5-isopropylbiguanide

Imidodicarbonimidic diamide, N-(3,4-dichlorophenyl)-N'-(1-methylethyl)-

M-5943

N-(3,4-Dichlorophenyl)-N'-isopropyldicarbonimido/ic diamide/imido

chlorproguanil

537-21-3

C11H16Cl3N5

Amines

Aromatics

Intermediates & Fine Chemicals

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