NICOTINIC ACID HYDRAZIDE
- Product Name
- NICOTINIC ACID HYDRAZIDE
- CAS No.
- 553-53-7
- Chemical Name
- NICOTINIC ACID HYDRAZIDE
- Synonyms
- ws102;Niazid;WS 102;NSC 36088;3-Isoniazid;WLN: T6NJ CVMZ;AKOS BBS-00004102;NICOTINOHYDRAZIDE;Nicotinylhydrazide;Nicotinylhydrazine
- CBNumber
- CB5491636
- Molecular Formula
- C6H7N3O
- Formula Weight
- 137.14
- MOL File
- 553-53-7.mol
NICOTINIC ACID HYDRAZIDE Property
- Melting point:
- 159-161 °C(lit.)
- Boiling point:
- 251.97°C (rough estimate)
- Density
- 1.2620 (rough estimate)
- refractive index
- 1.6910 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- H2O: soluble50mg/mL
- form
- Fine Needle-Like Crystalline Powder
- pka
- 11.43±0.10(Predicted)
- color
- White to off-white
- Water Solubility
- Soluble in alcohol, water.
- BRN
- 119299
- InChI
- InChI=1S/C6H7N3O/c7-9-6(10)5-2-1-3-8-4-5/h1-4H,7H2,(H,9,10)
- InChIKey
- KFUSANSHCADHNJ-UHFFFAOYSA-N
- SMILES
- C1=NC=CC=C1C(NN)=O
- CAS DataBase Reference
- 553-53-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-26-36/37/39
- RIDADR
- UN2811
- WGK Germany
- 3
- RTECS
- QT1750000
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29280000
- Toxicity
- LD50 intravenous in mouse: 180mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 107425
- Product name
- Nicotinic hydrazide
- Purity
- 97%
- Packaging
- 25g
- Price
- $97.4
- Updated
- 2025/07/31
- Product number
- 107425
- Product name
- Nicotinic hydrazide
- Purity
- 97%
- Packaging
- 100g
- Price
- $328
- Updated
- 2023/06/20
- Product number
- N0087
- Product name
- Nicotinic Acid Hydrazide
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- N0087
- Product name
- Nicotinic Acid Hydrazide
- Purity
- >98.0%(GC)(T)
- Packaging
- 100g
- Price
- $81
- Updated
- 2025/07/31
- Product number
- I821460
- Product name
- 3-Isoniazid
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
NICOTINIC ACID HYDRAZIDE Chemical Properties,Usage,Production
Chemical Properties
WHITE TO OFF-WHITE FINE NEEDLE-LIKE CRYST. POWDER
Uses
Nicotinic hydrazide was used in hydrazone library formation. It was used to study the oxidation of isonicotinic acid hydrazide (isoniazid) by horseradish peroxidase.
Uses
An Impurity of Isoniazid (I821450), potent antitubercular agent against M. tuberculosis.
Biochem/physiol Actions
Nicotinic hydrazide is an inhibitor of peroxidase enzyme. It forms solid metal complexes having strong biological activity.
Synthesis
93-60-7
553-53-7
The general procedure for the synthesis of 3-pyridinecarbohydrazide from methyl nicotinate was as follows: accurately weigh methyl 3-pyridinecarboxylate (2.74 g, 20 mmol) in a 50 mL round-bottomed flask, add anhydrous ethanol (15 mL), and stir at room temperature until the solid was completely dissolved. Subsequently, 80% hydrazine hydrate (30 mmol) was slowly added dropwise and immediately a large amount of needle-like white solid was observed to precipitate. The reaction mixture was continued to be stirred at room temperature for 3 h. Upon completion of the reaction, diafiltration was carried out and the solid was washed with a small amount of ethanol, resulting in 2.56 g of white needle-like crystals in 93.2% yield.
Purification Methods
Crystallise it from aqueous EtOH or *benzene. [Beilstein 22 III/IV 439, 22/2 V 121.]
References
[1] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 7, p. 1381 - 1387
[2] Patent: CN104592217, 2018, B. Location in patent: Paragraph 0032; 0033; 0034
[3] Patent: WO2017/11466, 2017, A1. Location in patent: Paragraph 00473
[4] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 6, p. 2158 - 2171
[5] Patent: CN108484582, 2018, A. Location in patent: Paragraph 0031; 0036; 0037; 0038; 0039
NICOTINIC ACID HYDRAZIDE Preparation Products And Raw materials
Raw materials
Preparation Products
NICOTINIC ACID HYDRAZIDE Suppliers
- Tel
- 0745-2866851 17774575249
- sales@bingfengchem.com
- Country
- China
- ProdList
- 446
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- +49 3493/605464
- Fax
- +49 3493/605470
- sales@intatrade.de
- Country
- Germany
- ProdList
- 3572
- Advantage
- 66
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9883
- Advantage
- 59
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
View Lastest Price from NICOTINIC ACID HYDRAZIDE manufacturers
- Product
- NICOTINIC ACID HYDRAZIDE 553-53-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- NICOTINIC ACID HYDRAZIDE 553-53-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- NICOTINIC ACID HYDRAZIDE 553-53-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-02