PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE

Product Name: PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE
CAS No.: 1452-63-7
Chemical Name: PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE
Synonyms: WS-104;NSC-81875;2-Isoniazid;AKOS B014996;2-Isoniazide;AKOS BBS-00004147;picolinohydrazide;Picolinylhydrazide;Isoniazid 2-Isomer;Picoline hydrazide
CBNumber: CB9306653
Molecular Formula: C6H7N3O
Formula Weight: 137.14
MOL File: 1452-63-7.mol

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PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Property

Melting point:: 100°C
Density: 1.244
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 11.29±0.10(Predicted)
color: White to Off-White
CAS DataBase Reference: 1452-63-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39-24/25
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS000511
Product name: 2-Pyridinecarbohydrazide
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 1 g
Price: $87.5
Updated: 2025/07/31

TCI Chemical

Product number: P0426
Product name: 2-Pyridinecarboxylic Acid Hydrazide
Purity: >98.0%(T)
Packaging: 25g
Price: $261
Updated: 2025/07/31

TRC

Product number: I821455
Product name: 2-Isoniazid
Packaging: 2g
Price: $275
Updated: 2021/12/16

TRC

Product number: I821455
Product name: 2-Isoniazid
Packaging: 5g
Price: $640
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0031985
Product name: 2-PICOLINYL HYDRAZIDE
Purity: 95.00%
Packaging: 1G
Price: $716.1
Updated: 2021/12/16

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PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Chemical Properties,Usage,Production

Chemical Properties

White to off-white solid

Uses

Pyridine-2-carboxylic acid hydrazide is an impurity of Isoniazid (I821450), which is an antibiotic for treatment of Mycobacterium tuberculosis and inhibits mycolic acid biosynthesis. Intermediate used for the synthesis of analogs of antitumor agent 1-acetyl-2-picolinoylhydrazine.

Synthesis

2524-52-9

1452-63-7

General procedure for the synthesis of 2-pyridinecarbohydrazide from ethyl 2-pyridinecarboxylate: a mixed solution of ethyl pyridine-2-carboxylate (90 g) and hydrazine hydrate (60 g) in ethanol (400 ml) was reacted with stirring at 80°C for 4 hours. After completion of the reaction, the solvent was removed by evaporation to give the crude product. The crude product was co-stirred with ether and the resulting suspension was filtered and the wet filter cake was washed with a small amount of ethanol (50 mL) to give 76 g (93% yield) of 2-pyridinecarbohydrazide as a white solid. Mass spectral data: m/z 138.0 (M+H).

References

[1] Patent: WO2010/136971, 2010, A1. Location in patent: Page/Page column 12
[2] Patent: US2012/142710, 2012, A1. Location in patent: Page/Page column 6
[3] Patent: WO2012/76989, 2012, A1. Location in patent: Page/Page column 55; 64
[4] Asian Journal of Chemistry, 2010, vol. 22, # 7, p. 5535 - 5542
[5] Patent: WO2017/106427, 2017, A1. Location in patent: Page/Page column 37-38

PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Preparation Products And Raw materials

Raw materials

Hydrazinium hydroxide solution Ethyl acetate Dichloromethane Methanol 2-Picolinic acid Thionyl chloride

Preparation Products

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PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Suppliers

Americas 1 Canada 1 China 194 Europe 2 Germany 3 India 10 Japan 1 Russia 2 The Netherlands 1 Ukraine 1 United Kingdom 3 United States 19 Global 238

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Energy Chemical

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Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
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Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
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JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
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ProdList: 9976
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Shangchem Co., Ltd.

Tel: +86-21-68182121
Fax: +86-21-68182121
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Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
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Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Nanjing Vital Chemical Co., Ltd.

Tel: Please Send Email 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 4378
Advantage: 65

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View Lastest Price from PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE manufacturers

Henan Fengda Chemical Co., Ltd

Product: PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE 1452-63-7
Price: US $34.00-1.40/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-26

Dideu Industries Group Limited

Product: PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE 1452-63-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-26

Career Henan Chemical Co

Product: PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE 1452-63-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-07-02

1452-63-7, PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDERelated Search:

Isonicotinamide PYRIDINE-2-CARBOXAMIDE Pyridine-3-sulfonyl chloride hydrochloride PYRIDINE-3-SULFONIC ACID SODIUM SALT PYRIDINE-2,4-DICARBONITRILE Pyridine, 4-(diethylboryl)- Pyridine, 3-(3-ethoxyandrosta-5,16-dien-17-yl)- Pyridine, 3-[3-(1-methylethoxy)androsta-5,16-dien-17-yl]- 3,5-bis(pyridin-4-yl)-4-amino-1,2,4-triazole 2,5-BIS(4-PYRIDYL)-1,3,4-OXADIAZOLE 1-isonicotinyl-2-lactosylhydrazine 4-CHLORO-PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Pyridine-2,6-dicarbohydrazide 4-CHLOROPYRIDINE-2,6-DICARBOHYDRAZIDE PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE NICOTINIC ACID HYDRAZIDE Isoniazid Formylhydrazine

2-Isoniazid Impurity

AKOS B014996

AKOS BBS-00004147

2-PICOLINYL HYDRAZIDE

ART-CHEM-BB B014996

PYRIDINE-2-CARBOHYDRAZIDE

PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE

2-pyridinecarboxylic acid hydrazide

2-PICOLINYL HYDRAZIDE 98+%

NSC-81875

Picolinic hydrazide

WS-104

picolinohydrazide

Picolinic Acid Hydrazide

2-Isoniazid

Picolinylhydrazide

2-Pyridinecarboxylicacid,hydrazide(9CI)

2-Pyridinecarboxylic hydrazide

2-Pyridylcarboxylic acid hydrazide

2-Pyridinecarboxylic Acid Hydrazide, Picolinic Acid, 2-(Hydrazinocarbonyl)pyridine

Picolinoyl Hydrazide

Picolinoylhydrazine

2-Picolinyl Hydrazide Picolinic Acid Hydrazide

Isoniazid Impurity 4

Picolinohydrazide 2-

2-Pyridylcarbonylhydrazine

.alpha.-Picolinyl hydrazide

2-Isoniazide

2-PyridinecarboxylicAcidHydrazide&gt

Isoniazid 2-Isomer

PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE ISO 9001：2015 REACH

N-hydroxysulfosuccinimidyl biotin

Picoline hydrazide

Picolinohydrazide , 2-Pyridinecarbohydrazide

2-Pyridinecarbohydrazide, 10 mM in DMSO

1452-63-7

Amines, Aromatics, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals

Amines

Aromatics

Impurities

Intermediates & Fine Chemicals

Pharmaceuticals

AMIDE