PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE
- Product Name
- PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE
- CAS No.
- 1452-63-7
- Chemical Name
- PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE
- Synonyms
- WS-104;NSC-81875;2-Isoniazid;AKOS B014996;2-Isoniazide;AKOS BBS-00004147;picolinohydrazide;Picolinylhydrazide;Isoniazid 2-Isomer;Picoline hydrazide
- CBNumber
- CB9306653
- Molecular Formula
- C6H7N3O
- Formula Weight
- 137.14
- MOL File
- 1452-63-7.mol
PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Property
- Melting point:
- 100°C
- Density
- 1.244
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 11.29±0.10(Predicted)
- color
- White to Off-White
- CAS DataBase Reference
- 1452-63-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39-24/25
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- CDS000511
- Product name
- 2-Pyridinecarbohydrazide
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 1 g
- Price
- $87.5
- Updated
- 2025/07/31
- Product number
- P0426
- Product name
- 2-Pyridinecarboxylic Acid Hydrazide
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $261
- Updated
- 2025/07/31
- Product number
- I821455
- Product name
- 2-Isoniazid
- Packaging
- 2g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- I821455
- Product name
- 2-Isoniazid
- Packaging
- 5g
- Price
- $640
- Updated
- 2021/12/16
- Product number
- CHM0031985
- Product name
- 2-PICOLINYL HYDRAZIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $716.1
- Updated
- 2021/12/16
PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Chemical Properties,Usage,Production
Chemical Properties
White to off-white solid
Uses
Pyridine-2-carboxylic acid hydrazide is an impurity of Isoniazid (I821450), which is an antibiotic for treatment of Mycobacterium tuberculosis and inhibits mycolic acid biosynthesis. Intermediate used for the synthesis of analogs of antitumor agent 1-acetyl-2-picolinoylhydrazine.
Synthesis
2524-52-9
1452-63-7
General procedure for the synthesis of 2-pyridinecarbohydrazide from ethyl 2-pyridinecarboxylate: a mixed solution of ethyl pyridine-2-carboxylate (90 g) and hydrazine hydrate (60 g) in ethanol (400 ml) was reacted with stirring at 80°C for 4 hours. After completion of the reaction, the solvent was removed by evaporation to give the crude product. The crude product was co-stirred with ether and the resulting suspension was filtered and the wet filter cake was washed with a small amount of ethanol (50 mL) to give 76 g (93% yield) of 2-pyridinecarbohydrazide as a white solid. Mass spectral data: m/z 138.0 (M+H).
References
[1] Patent: WO2010/136971, 2010, A1. Location in patent: Page/Page column 12
[2] Patent: US2012/142710, 2012, A1. Location in patent: Page/Page column 6
[3] Patent: WO2012/76989, 2012, A1. Location in patent: Page/Page column 55; 64
[4] Asian Journal of Chemistry, 2010, vol. 22, # 7, p. 5535 - 5542
[5] Patent: WO2017/106427, 2017, A1. Location in patent: Page/Page column 37-38
PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Preparation Products And Raw materials
Raw materials
Preparation Products
PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Suppliers
- Tel
- --
- Fax
- --
- y.barysheva@ukrorgsynth.com
- Country
- Ukraine
- ProdList
- 6230
- Advantage
- 38
View Lastest Price from PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE manufacturers
- Product
- PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE 1452-63-7
- Price
- US $34.00-1.40/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-26
- Product
- PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE 1452-63-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-26
- Product
- PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE 1452-63-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-02