ChemicalBook > CAS DataBase List > ZT-12-037-01

ZT-12-037-01

Product Name
ZT-12-037-01
CAS No.
2328073-61-4
Chemical Name
ZT-12-037-01
Synonyms
ZT-12-037-01;ZT-12-037-01, 10 mM in DMSO;inhibit,ZT 12 037 01,ZT1203701,Ras,Inhibitor;N2-Cyclopropyl-N4-(1-isopropylpiperidin-4-yl)-6,7-dimethoxyquinazoline-2,4-diamine;2,4-Quinazolinediamine, N2-cyclopropyl-6,7-dimethoxy-N4-[1-(1-methylethyl)-4-piperidinyl]-
CBNumber
CB54927142
Molecular Formula
C21H31N5O2
Formula Weight
385.5
MOL File
2328073-61-4.mol
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ZT-12-037-01 Property

storage temp. 
2-8°C(protect from light)
solubility 
DMSO: 8.33 mg/mL (21.61 mM)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0090099
Product name
ZT-12-037-01
Purity
98.21%
Packaging
5mg
Price
$80
Updated
2021/12/16
ChemScene
Product number
CS-0090099
Product name
ZT-12-037-01
Purity
98.21%
Packaging
10mg
Price
$140
Updated
2021/12/16
Axon Medchem
Product number
Axon2937
Product name
ZT-12-037-01
Purity
99%
Packaging
25mg
Price
$335.5
Updated
2021/12/16
ChemScene
Product number
CS-0090099
Product name
ZT-12-037-01
Purity
98.21%
Packaging
50mg
Price
$560
Updated
2021/12/16
ChemScene
Product number
CS-0090099
Product name
ZT-12-037-01
Purity
98.21%
Packaging
100mg
Price
$980
Updated
2021/12/16
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ZT-12-037-01 Chemical Properties,Usage,Production

Uses

ZT-12-037-01 is a STK19-targeted inhibitor, has a high-affinity interaction with STK19 protein and inhibits oncogenic NRAS-driven melanocyte malignant transformation. ZT-12-037-01 is an ATP-competitive inhibitor, inhibiting phosphorylation of NRAS (major isoform of Ras family) with an IC50 of 24 nM[1].

Biological Activity

ZT-12-037-01 is an ATP-competitive STK19 inhibitor with IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. At a concentration of 1 μM, it is highly selective against a kinase library of 468 kinases.

in vitro

Treatment with ZT-12-037-01 could effectively inhibit NRAS phosphorylation. ZT-12-037-01 is an ATP-competitive inhibitor that potently inhibits melanocytic colony formation, proliferation and tumor formation driven by mutant NRAS-STK19. It's pro-apoptotic activity was significantly enhanced in cells expressing oncogenic NRAS.

in vivo

ZT-12-037-01 is a potent STK19 inhibitor with low toxicity in vivo. In the SK-MEL-2 xenograft model (carrying NRAS.

target

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References

[1] Yin C, et al. Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. Cell. 2019 Feb 21;176(5):1113-1127.e16. DOI:10.1016/j.cell.2019.01.002

ZT-12-037-01 Preparation Products And Raw materials

Raw materials

Preparation Products

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ZT-12-037-01 Suppliers

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2328073-61-4, ZT-12-037-01Related Search:

Z-Vad-fmk, non-methylated (Z)-CAPSAICIN ZSTK474 Z-VAD-FMK

  • ZT-12-037-01
  • 2,4-Quinazolinediamine, N2-cyclopropyl-6,7-dimethoxy-N4-[1-(1-methylethyl)-4-piperidinyl]-
  • inhibit,ZT 12 037 01,ZT1203701,Ras,Inhibitor
  • N2-Cyclopropyl-N4-(1-isopropylpiperidin-4-yl)-6,7-dimethoxyquinazoline-2,4-diamine
  • ZT-12-037-01, 10 mM in DMSO
  • 2328073-61-4
    • TargetValue
    STK19
    (Cell-free assay)    		 23.96 nM
    STK19 (D89N)
    (Cell-free assay)    		 27.94 nM