Z-Vad-fmk, non-methylated

Product Name: Z-Vad-fmk, non-methylated
CAS No.: 161401-82-7
Chemical Name: Z-Vad-fmk, non-methylated
Synonyms: Z-VAD;abs817872;Z-VAD-FMK, Free Acid;Z-VAD-FMK, 10 mM in DMSO;Z-VAD-FMK (Caspase Inhibitor VI);Z-VAD(OH)-FMK (Caspase Inhibitor VI);Z-VAL-ALA-ASP-(OH)-FLUOROMETHYL KETONE;Carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketone;Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem;inhibit,Inhibitor,ZVADFMK,Hela,Z VAD FMK,Caspase,Antiapoptosis,cells,pan-caspase
CBNumber: CB42497499
Molecular Formula: C21H28FN3O7
Formula Weight: 453.46
MOL File: 161401-82-7.mol

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Z-Vad-fmk, non-methylated Property

Boiling point:: 758.0±60.0 °C(Predicted)
Density: 1.260±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO:5.0(Max Conc. mg/mL);11.0(Max Conc. mM)
form: Off-white solid
pka: 3.91±0.19(Predicted)
color: White to light yellow
InChIKey: KCZVXULVWPSIGV-YEWWUXTCSA-N
SMILES: C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)[C@@H](CC(O)=O)C(=O)CF

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 219007
Product name: Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem
Purity: Z-VAD-FMK, CAS 161401-82-7, is an irreversible pan caspase inhibitor. Does not require pretreatment with esterase for in vitro studies.
Packaging: 250μg
Price: $116
Updated: 2025/07/31

Sigma-Aldrich

Product number: 219007
Product name: Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem<br />Z-VAD-FMK, CAS 161401-82-7, is an irreversible pan caspase inhibitor. Does not require pretreatment with esterase for in vitro studies.
Packaging: 1mg
Price: $312
Updated: 2025/07/31

Cayman Chemical

Product number: 14467
Product name: Z-VAD(OH)-FMK
Purity: ≥95%
Packaging: 500μg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 14467
Product name: Z-VAD(OH)-FMK
Purity: ≥95%
Packaging: 1mg
Price: $131
Updated: 2024/03/01

Cayman Chemical

Product number: 14467
Product name: Z-VAD(OH)-FMK
Purity: ≥95%
Packaging: 5mg
Price: $380
Updated: 2024/03/01

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Z-Vad-fmk, non-methylated Chemical Properties,Usage,Production

Description

Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases. This non-methylated form is useful in studies involving recombinant, isolated, or purified enzymes. Unlike the methylated form, Z-VAD(OMe)-FMK , this compound does not require pretreatment with esterases prior to in vitro use.

Uses

Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL1) activity even at concentrations as high as 440 μM[1].

General Description

An irreversible general caspase inhibitor. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies. A 10 mM (1 mg/221 μl) solution of Caspase Inhibitor VI (Cat. No. 219011) in DMSO is also available.

Biochem/physiol Actions

Product does not compete with ATP.

IC 50

Caspase

References

[1] Davies CW, et al. The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK). Bioorg Med Chem Lett. 2012 Jun 15;22(12):3900-4. DOI:10.1016/j.bmcl.2012.04.124
[2] Liu HR, et al. Antiproliferative activity of the total saponin of Solanum lyratum Thunb in Hela cells by inducing apoptosis. Pharmazie. 2008 Nov;63(11):836-42. PMID:19069247

Z-Vad-fmk, non-methylated Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-Vad-fmk, non-methylated Suppliers

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Z-VAD-FMK, Free Acid

Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem

abs817872

(5S,8S,11S)-11-(2-Fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oic acid

Z-VAD

inhibit,Inhibitor,ZVADFMK,Hela,Z VAD FMK,Caspase,Antiapoptosis,cells,pan-caspase

Z-VAD-FMK, 10 mM in DMSO

161401-82-7

C21H28FN3O7