CASPASE-8 INHIBITOR II
- Product Name
- CASPASE-8 INHIBITOR II
- CAS No.
- 210344-98-2
- Chemical Name
- CASPASE-8 INHIBITOR II
- Synonyms
- Z-IETD-FMK;Z-IETD-FMK?, >98%;Z-IE(OME)TD(OME)-FMK;CASPASE-8 INHIBITOR II;GRANZYME B INHIBITOR III;Z-IETD-FMK, 10 mM in DMSO;Z-ILE-GLU(OME)-THR-ASP(OME)-FMK;Z-IE(OME)TD(OME)-FLUOROMETHYLKETONE;CASPASE-8 INHIBITOR;Z-IE(OME)TD(OME)-FMK;inhibit,Inhibitor,Caspase,Z IETD FMK,ZIETDFMK
- CBNumber
- CB9280050
- Molecular Formula
- C30H43FN4O11
- Formula Weight
- 654.68
- MOL File
- Mol file
CASPASE-8 INHIBITOR II Property
- Boiling point:
- 925.7±65.0 °C(Predicted)
- Density
- 1.247±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 11.12±0.46(Predicted)
- color
- White to light yellow
- Sequence
- Z-Ile-Glu-Thr-Asp-FMK
- InChIKey
- PHLCQASLWHYEMX-DEKIMQJDSA-N
- SMILES
- [C@@H]([C@@H](C)CC)(NC(=O)OCC1C=CC=CC=1)C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@H](C(=O)CF)CC(=O)OC
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B3232
- Product name
- Z-IETD-FMK
- Packaging
- 1mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- B3232
- Product name
- Z-IETD-FMK
- Packaging
- 20ul(10mM)
- Price
- $125
- Updated
- 2021/12/16
- Product number
- B3232
- Product name
- Z-IETD-FMK
- Packaging
- 100ul(2mM)
- Price
- $125
- Updated
- 2021/12/16
- Product number
- AK316562
- Product name
- Z-IETD-FMK
- Purity
- 95+%
- Packaging
- 1mg
- Price
- $204
- Updated
- 2021/12/16
- Product number
- 32758
- Product name
- Z-Ile-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone
- Packaging
- 1MG
- Price
- $287.5
- Updated
- 2021/12/16
CASPASE-8 INHIBITOR II Chemical Properties,Usage,Production
Uses
A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B.
Biological Activity
z-ietd-fmk is an inhibitor of caspase 8 [1].z-ietd-fmk inhibits t cell proliferation induced by pha or anti-cd3 plus anti-cd28 without toxicity of resting t cells. the mechanism of this inhibition of z-ietd-fmk has been proved not through the effect on il-2 secretion or ifn-γ production but the decrease of cd25 expression. experiments show that z-ietd-fmk has no effect on normal cell growth when there is no activation signal. z-ietd-fmk has also been found to significantly inhibit nf-κb activation when the concentration is 100μm [1].apart from the ability of inhibiting cell proliferation, z-ietd-fmk is reported to inhibit trail-mediated killing in cells. it protects the procaspases 9, 2, and 3, and protects parp to a similar extent in both hct116 and sw480 cells [2].
in vivo
Pharmacological inhibition of caspase-8 by z-IETD-FMK robustly reduces tumor growth and this is closely associated with a reduction in the release of pro-inflammatory cytokines, IL-6, TNF-α, IL-18, IL-1α, IL-33, but not IL-1β. Furthermore, inhibition of caspase-8 reduces the recruitment of innate suppressive cells, such as myeloid-derived suppressor cells, but not of regulatory T cells to lungs of tumor-bearing mice[4].
target
caspase 8
IC 50
Caspase-8
References
[1] c.p. lawrence, s.c. chow. suppression of human t cell proliferation by the caspase inhibitors, z-vad-fmk and z-ietd-fmk is independent of their caspase inhibition properties. toxicology and applied pharmacology. 2012, 265: 103-112.
[2] nesrin özören, kunhong kim, timothy f. burns, et al. the caspase 9 inhibitor z-lehd-fmk protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. cancer research. 2000, 60: 6259-6265.
CASPASE-8 INHIBITOR II Preparation Products And Raw materials
Raw materials
Preparation Products
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