ChemicalBook > CAS DataBase List > CASPASE-8 INHIBITOR II

CASPASE-8 INHIBITOR II

Product Name
CASPASE-8 INHIBITOR II
CAS No.
210344-98-2
Chemical Name
CASPASE-8 INHIBITOR II
Synonyms
Z-IETD-FMK;Z-IETD-FMK?, >98%;Z-IE(OME)TD(OME)-FMK;CASPASE-8 INHIBITOR II;GRANZYME B INHIBITOR III;Z-ILE-GLU(OME)-THR-ASP(OME)-FMK;Z-IE(OME)TD(OME)-FLUOROMETHYLKETONE;CASPASE-8 INHIBITOR;Z-IE(OME)TD(OME)-FMK;inhibit,Inhibitor,Caspase,Z IETD FMK,ZIETDFMK;Z-ILE-GLU(OME)-THR-ASP(OME)-FLUOROMETHYLKETONE
CBNumber
CB9280050
Molecular Formula
C30H43FN4O11
Formula Weight
654.68
MOL File
Mol file
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CASPASE-8 INHIBITOR II Property

Boiling point:
925.7±65.0 °C(Predicted)
Density 
1.247±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in DMSO
form 
Powder
pka
11.12±0.46(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology
Product number
B3232
Product name
Z-IETD-FMK
Packaging
20ul(10mM)
Price
$125
Updated
2021/12/16
ApexBio Technology
Product number
B3232
Product name
Z-IETD-FMK
Packaging
100ul(2mM)
Price
$125
Updated
2021/12/16
Ark Pharm
Product number
AK316562
Product name
Z-IETD-FMK
Purity
95+%
Packaging
1mg
Price
$204
Updated
2021/12/16
ApexBio Technology
Product number
B3232
Product name
Z-IETD-FMK
Packaging
1mg
Price
$240
Updated
2021/12/16
Chem-Impex
Product number
32758
Product name
Z-Ile-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone
Packaging
1MG
Price
$287.5
Updated
2021/12/16
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CASPASE-8 INHIBITOR II Chemical Properties,Usage,Production

Uses

A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B.

Biological Activity

z-ietd-fmk is an inhibitor of caspase 8 [1].z-ietd-fmk inhibits t cell proliferation induced by pha or anti-cd3 plus anti-cd28 without toxicity of resting t cells. the mechanism of this inhibition of z-ietd-fmk has been proved not through the effect on il-2 secretion or ifn-γ production but the decrease of cd25 expression. experiments show that z-ietd-fmk has no effect on normal cell growth when there is no activation signal. z-ietd-fmk has also been found to significantly inhibit nf-κb activation when the concentration is 100μm [1].apart from the ability of inhibiting cell proliferation, z-ietd-fmk is reported to inhibit trail-mediated killing in cells. it protects the procaspases 9, 2, and 3, and protects parp to a similar extent in both hct116 and sw480 cells [2].

target

caspase 8

References

[1] c.p. lawrence, s.c. chow. suppression of human t cell proliferation by the caspase inhibitors, z-vad-fmk and z-ietd-fmk is independent of their caspase inhibition properties. toxicology and applied pharmacology. 2012, 265: 103-112.
[2] nesrin özören, kunhong kim, timothy f. burns, et al. the caspase 9 inhibitor z-lehd-fmk protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. cancer research. 2000, 60: 6259-6265.

CASPASE-8 INHIBITOR II Preparation Products And Raw materials

Raw materials

Preparation Products

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CASPASE-8 INHIBITOR II Suppliers

Shanghai BRILLIA Pharmaceutical Co., Ltd
Tel
17740884366
Email
derek1229@163.com
Country
China
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Jiangsu Shenlang Biotechnology Co., Ltd.
Tel
18914398991
Fax
0513-81001007
Email
1582941412@qq.com
Country
China
ProdList
21
Advantage
58
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
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Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6013
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61
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
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64
Shanghai Harvest Chemical Industrial Co., Ltd.
Tel
21-31038972 15721252604
Fax
+86-21-51385350
Email
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Country
China
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2510
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Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
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China
ProdList
42982
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Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
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shchemsky@sina.com
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China
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Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
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sales@trio-pharmatech.com (International market)
Country
China
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Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4648
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210344-98-2, CASPASE-8 INHIBITOR IIRelated Search:


  • BENZYLOXYCARBONYL-ILE-GLU(OME)-THR-ASP(OME)-FLUOROMETHYLKETONE
  • GRANZYME B INHIBITOR III
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  • CASPASE-3 PROCESSING ENZYME INHIBITOR (FLUOROMETHYLKETONE)
  • Z-IETD-FMK
  • Z-ILE-GLU(OME)-THR-ASP(OME)-FLUOROMETHYLKETONE
  • Z-ILE-GLU(OME)-THR-ASP(OME)-FMK
  • Z-ILE-GLU(OME)-THR-DL-ASP(OME)-FLUOROMETHYLKETONE
  • Z-IE(OME)TD(OME)-FLUOROMETHYLKETONE
  • Z-IE(OME)TD(OME)-FMK
  • CASPASE-8 INHIBITOR;Z-IE(OME)TD(OME)-FMK
  • Z-IETD-FMK?, >98%
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  • inhibit,Inhibitor,Caspase,Z IETD FMK,ZIETDFMK
  • 210344-98-2
  • 210344-95-2
  • C30H43FN4O11
  • Caspases/Apoptosis
  • Caspase/Related Products