CASPASE-8 INHIBITOR II

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CASPASE-8 INHIBITOR II

Product Name: CASPASE-8 INHIBITOR II
CAS No.: 210344-98-2
Chemical Name: CASPASE-8 INHIBITOR II
Synonyms: Z-IETD-FMK;Z-IETD-FMK?, >98%;Z-IE(OME)TD(OME)-FMK;CASPASE-8 INHIBITOR II;GRANZYME B INHIBITOR III;Z-ILE-GLU(OME)-THR-ASP(OME)-FMK;Z-IE(OME)TD(OME)-FLUOROMETHYLKETONE;CASPASE-8 INHIBITOR;Z-IE(OME)TD(OME)-FMK;inhibit,Inhibitor,Caspase,Z IETD FMK,ZIETDFMK;Z-ILE-GLU(OME)-THR-ASP(OME)-FLUOROMETHYLKETONE
CBNumber: CB9280050
Molecular Formula: C30H43FN4O11
Formula Weight: 654.68
MOL File: Mol file

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CASPASE-8 INHIBITOR II Property

Boiling point:: 925.7±65.0 °C(Predicted)
Density: 1.247±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Soluble in DMSO
form: Powder
pka: 11.12±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B3232
Product name: Z-IETD-FMK
Packaging: 1mg
Price: $240
Updated: 2021/12/16

ApexBio Technology

Product number: B3232
Product name: Z-IETD-FMK
Packaging: 20ul(10mM)
Price: $125
Updated: 2021/12/16

ApexBio Technology

Product number: B3232
Product name: Z-IETD-FMK
Packaging: 100ul(2mM)
Price: $125
Updated: 2021/12/16

Ark Pharm

Product number: AK316562
Product name: Z-IETD-FMK
Purity: 95+%
Packaging: 1mg
Price: $204
Updated: 2021/12/16

Chem-Impex

Product number: 32758
Product name: Z-Ile-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone
Packaging: 1MG
Price: $287.5
Updated: 2021/12/16

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CASPASE-8 INHIBITOR II Chemical Properties,Usage,Production

Uses

A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B.

Biological Activity

z-ietd-fmk is an inhibitor of caspase 8 [1].z-ietd-fmk inhibits t cell proliferation induced by pha or anti-cd3 plus anti-cd28 without toxicity of resting t cells. the mechanism of this inhibition of z-ietd-fmk has been proved not through the effect on il-2 secretion or ifn-γ production but the decrease of cd25 expression. experiments show that z-ietd-fmk has no effect on normal cell growth when there is no activation signal. z-ietd-fmk has also been found to significantly inhibit nf-κb activation when the concentration is 100μm [1].apart from the ability of inhibiting cell proliferation, z-ietd-fmk is reported to inhibit trail-mediated killing in cells. it protects the procaspases 9, 2, and 3, and protects parp to a similar extent in both hct116 and sw480 cells [2].

target

caspase 8

References

[1] c.p. lawrence, s.c. chow. suppression of human t cell proliferation by the caspase inhibitors, z-vad-fmk and z-ietd-fmk is independent of their caspase inhibition properties. toxicology and applied pharmacology. 2012, 265: 103-112.
[2] nesrin özören, kunhong kim, timothy f. burns, et al. the caspase 9 inhibitor z-lehd-fmk protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. cancer research. 2000, 60: 6259-6265.

CASPASE-8 INHIBITOR II Preparation Products And Raw materials

Raw materials

Preparation Products

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210344-98-2, CASPASE-8 INHIBITOR IIRelated Search:

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C30H43FN4O11

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