ChemicalBook > CAS DataBase List > CASPASE-8 INHIBITOR II
CASPASE-8 INHIBITOR II
- Product Name
- CASPASE-8 INHIBITOR II
- CAS No.
- 210344-98-2
- Chemical Name
- CASPASE-8 INHIBITOR II
- Synonyms
- Z-IETD-FMK;Z-IETD-FMK?, >98%;Z-IE(OME)TD(OME)-FMK;CASPASE-8 INHIBITOR II;GRANZYME B INHIBITOR III;Z-IETD-FMK, 10 mM in DMSO;Z-ILE-GLU(OME)-THR-ASP(OME)-FMK;Z-IE(OME)TD(OME)-FLUOROMETHYLKETONE;CASPASE-8 INHIBITOR;Z-IE(OME)TD(OME)-FMK;inhibit,Inhibitor,Caspase,Z IETD FMK,ZIETDFMK
- CBNumber
- CB9280050
- Molecular Formula
- C30H43FN4O11
- Formula Weight
- 654.68
- MOL File
- Mol file
More
Less
CASPASE-8 INHIBITOR II Property
- Boiling point:
- 925.7±65.0 °C(Predicted)
- Density
- 1.247±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 11.12±0.46(Predicted)
- color
- White to light yellow
- Sequence
- Z-Ile-Glu-Thr-Asp-FMK
- InChIKey
- PHLCQASLWHYEMX-DEKIMQJDSA-N
- SMILES
- [C@@H]([C@@H](C)CC)(NC(=O)OCC1C=CC=CC=1)C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@H](C(=O)CF)CC(=O)OC
More
Less
N-Bromosuccinimide Price
ApexBio Technology
- Product number
- B3232
- Product name
- Z-IETD-FMK
- Packaging
- 20ul(10mM)
- Price
- $125
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B3232
- Product name
- Z-IETD-FMK
- Packaging
- 100ul(2mM)
- Price
- $125
- Updated
- 2021/12/16
Ark Pharm
- Product number
- AK316562
- Product name
- Z-IETD-FMK
- Purity
- 95+%
- Packaging
- 1mg
- Price
- $204
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B3232
- Product name
- Z-IETD-FMK
- Packaging
- 1mg
- Price
- $240
- Updated
- 2021/12/16
Chem-Impex
- Product number
- 32758
- Product name
- Z-Ile-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone
- Packaging
- 1MG
- Price
- $287.5
- Updated
- 2021/12/16
More
Less
CASPASE-8 INHIBITOR II Chemical Properties,Usage,Production
Uses
A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B.
Biological Activity
z-ietd-fmk is an inhibitor of caspase 8 [1].z-ietd-fmk inhibits t cell proliferation induced by pha or anti-cd3 plus anti-cd28 without toxicity of resting t cells. the mechanism of this inhibition of z-ietd-fmk has been proved not through the effect on il-2 secretion or ifn-γ production but the decrease of cd25 expression. experiments show that z-ietd-fmk has no effect on normal cell growth when there is no activation signal. z-ietd-fmk has also been found to significantly inhibit nf-κb activation when the concentration is 100μm [1].apart from the ability of inhibiting cell proliferation, z-ietd-fmk is reported to inhibit trail-mediated killing in cells. it protects the procaspases 9, 2, and 3, and protects parp to a similar extent in both hct116 and sw480 cells [2].
in vivo
Pharmacological inhibition of caspase-8 by z-IETD-FMK robustly reduces tumor growth and this is closely associated with a reduction in the release of pro-inflammatory cytokines, IL-6, TNF-α, IL-18, IL-1α, IL-33, but not IL-1β. Furthermore, inhibition of caspase-8 reduces the recruitment of innate suppressive cells, such as myeloid-derived suppressor cells, but not of regulatory T cells to lungs of tumor-bearing mice[4].
target
caspase 8
IC 50
Caspase-8
References
[1] c.p. lawrence, s.c. chow. suppression of human t cell proliferation by the caspase inhibitors, z-vad-fmk and z-ietd-fmk is independent of their caspase inhibition properties. toxicology and applied pharmacology. 2012, 265: 103-112.
[2] nesrin özören, kunhong kim, timothy f. burns, et al. the caspase 9 inhibitor z-lehd-fmk protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. cancer research. 2000, 60: 6259-6265.
CASPASE-8 INHIBITOR II Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
CASPASE-8 INHIBITOR II Suppliers
- Tel
- 17740884366
- derek1229@163.com
- Country
- China
- ProdList
- 61
- Advantage
- 58
- Tel
- 0513-89078808 13764678260
- Fax
- 0513-81001007
- 1582941412@qq.com
- Country
- China
- ProdList
- 18
- Advantage
- 58
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6003
- Advantage
- 61
- Tel
- 021-31038972,31038973 17321035817
- Fax
- +86-21-51385350
- sales@harvest-chem.com
- Country
- China
- ProdList
- 2816
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 15402
- Advantage
- 60
- Tel
- 0531-88811783
- Fax
- +86 (531) 55696010 QQ 1762738062
- sales@trio-pharmatech.com
- Country
- China
- ProdList
- 1856
- Advantage
- 62
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4747
- Advantage
- 58
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7782
- Advantage
- 58
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3506
- Advantage
- 58
- Tel
- 021-24206007 13764915196
- Fax
- 86-021-23027023
- sales@balmxy.com
- Country
- China
- ProdList
- 6874
- Advantage
- 55
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2990
- Advantage
- 60
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51395
- Advantage
- 80
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4768
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 021-20242659 18930833303
- Fax
- +86 (21) 2024-2659
- Sales@changyanchem.cn
- Country
- China
- ProdList
- 5001
- Advantage
- 55
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 9125
- Advantage
- 58
- Tel
- 0-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
- Country
- China
- ProdList
- 12475
- Advantage
- 58
- Tel
- 010-50973130 18101056239
- 3193328036@qq.com
- Country
- China
- ProdList
- 29759
- Advantage
- 68
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 021-58180488
- Fax
- 021-58180499
- sales@MedChemLeader.com
- Country
- China
- ProdList
- 1006
- Advantage
- 58
- Tel
- 010-62971590 18548936886
- Fax
- 010-62340519
- 3462612863@qq.com
- Country
- China
- ProdList
- 10063
- Advantage
- 58
- Tel
- 0411-39042497
- Fax
- 0411-39042693
- sales@alphabiopharm.com
- Country
- China
- ProdList
- 1951
- Advantage
- 58
- Tel
- 010-82387566 18001021521;
- Fax
- 82387566-801
- sales@mreda.com.cn
- Country
- China
- ProdList
- 10083
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- 020-31155029 18902330969
- Fax
- 020-31155029
- sales@tomums.cn
- Country
- China
- ProdList
- 4696
- Advantage
- 58
- Tel
- +86-0576-88813233 +86-13396860566
- sales@pharm-intermediates.com
- Country
- China
- ProdList
- 1991
- Advantage
- 58
- Tel
- +86-0571-81612335 +8613336028439
- sales@nextpeptide.com
- Country
- China
- ProdList
- 19908
- Advantage
- 58
- Tel
- +86-0519-85788828 +86-13775037613
- sales@chemrenpharm.com
- Country
- China
- ProdList
- 3934
- Advantage
- 58
- Tel
- 13969155946
- 1461866103@qq.com
- Country
- China
- ProdList
- 16111
- Advantage
- 58
- Tel
- 0531-0000
- thinklifescience@163.com
- Country
- China
- ProdList
- 19689
- Advantage
- 58
- Tel
- 020-82000279 18988941452
- Fax
- QQ：3283937693
- YN_research@163.com
- Country
- China
- ProdList
- 3011
- Advantage
- 58
- Tel
- 021-38015121 18438616290
- lanwu@univ-bio.com
- Country
- China
- ProdList
- 24731
- Advantage
- 58
- Tel
- 13758194781 13173652190
- 522013271@qq.com
- Country
- China
- ProdList
- 2395
- Advantage
- 58
- Tel
- 16621358918
- Fax
- QQ:402135374
- botuopharma888@163.com
- Country
- China
- ProdList
- 9208
- Advantage
- 58
- Tel
- 0571-88760729 18072970094
- supports@ontorespeptide.com
- Country
- China
- ProdList
- 2696
- Advantage
- 58
- Tel
- 17269768198
- Fax
- QQ:1213744847
- prochemx@163.com
- Country
- China
- ProdList
- 613
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44894
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 021-50967598 02150967598
- sales@abmole.cn
- Country
- China
- ProdList
- 4494
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29757
- Advantage
- 58
- Tel
- 021-57646680 18306277365
- guoxin@chembiobanksh.com
- Country
- China
- ProdList
- 2666
- Advantage
- 58
- Tel
- 0513-68819626; 15152877458
- Fax
- 0513-68669626
- feiyubio@163.com
- Country
- China
- ProdList
- 4817
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- 2625930290@qq.com
- Country
- China
- ProdList
- 6973
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 59936
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6753
- Advantage
- 58
- Tel
- 17711399154
- 3211919385@qq.com
- Country
- China
- ProdList
- 1815
- Advantage
- 58
- Tel
- 0371-55013243 15324716602
- 2853979810@qq.com
- Country
- China
- ProdList
- 9898
- Advantage
- 58
210344-98-2, CASPASE-8 INHIBITOR IIRelated Search:
libaotao
Urease inhibitor
Z-PHE-DL-ALA-FLUOROMETHYLKETONE
Z-DEVD-FMK
Z-Vad-fmk, non-methylated
Z-VAD-FMK