ZT-12-037-01
- Product Name
- ZT-12-037-01
- CAS No.
- 2328073-61-4
- Chemical Name
- ZT-12-037-01
- Synonyms
- ZT-12-037-01;inhibit,ZT 12 037 01,ZT1203701,Ras,Inhibitor;N2-Cyclopropyl-N4-(1-isopropylpiperidin-4-yl)-6,7-dimethoxyquinazoline-2,4-diamine;2,4-Quinazolinediamine, N2-cyclopropyl-6,7-dimethoxy-N4-[1-(1-methylethyl)-4-piperidinyl]-
- CBNumber
- CB54927142
- Molecular Formula
- C21H31N5O2
- Formula Weight
- 385.5
- MOL File
- 2328073-61-4.mol
ZT-12-037-01 Property
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO: 8.33 mg/mL (21.61 mM)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0090099
- Product name
- ZT-12-037-01
- Purity
- 98.21%
- Packaging
- 5mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- CS-0090099
- Product name
- ZT-12-037-01
- Purity
- 98.21%
- Packaging
- 10mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- Axon2937
- Product name
- ZT-12-037-01
- Purity
- 99%
- Packaging
- 25mg
- Price
- $335.5
- Updated
- 2021/12/16
- Product number
- CS-0090099
- Product name
- ZT-12-037-01
- Purity
- 98.21%
- Packaging
- 50mg
- Price
- $560
- Updated
- 2021/12/16
- Product number
- CS-0090099
- Product name
- ZT-12-037-01
- Purity
- 98.21%
- Packaging
- 100mg
- Price
- $980
- Updated
- 2021/12/16
ZT-12-037-01 Chemical Properties,Usage,Production
Biological Activity
ZT-12-037-01 is an ATP-competitive STK19 inhibitor with IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. At a concentration of 1 μM, it is highly selective against a kinase library of 468 kinases.
in vitro
Treatment with ZT-12-037-01 could effectively inhibit NRAS phosphorylation. ZT-12-037-01 is an ATP-competitive inhibitor that potently inhibits melanocytic colony formation, proliferation and tumor formation driven by mutant NRAS-STK19. It's pro-apoptotic activity was significantly enhanced in cells expressing oncogenic NRAS.
in vivo
ZT-12-037-01 is a potent STK19 inhibitor with low toxicity in vivo. In the SK-MEL-2 xenograft model (carrying NRAS.
target
| Target | Value |
| STK19 (Cell-free assay) | 23.96 nM |
| STK19 (D89N) (Cell-free assay) | 27.94 nM |