ChemicalBook > CAS DataBase List > 7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID

7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID

Product Name: 7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID
CAS No.: 779-27-1
Chemical Name: 7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID
Synonyms: 7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID;RARECHEM AL BO 2319;OTAVA-BB BB7015592710;3-CARBOXY-7-HYDROXYCOUMARIN;7-hydroxy-3-carboxycoumarin;UMBELLIFERONE-3-CARBOXYLIC ACID;7-HYDROXYCOUMARIM-3-CARBOXYLIC ACID;7-Hydroxycoumarin-3-carboxylicAcid>7-Hydroxycoumarin-3-carboxylic acid ,98%;7-hydroxy-2-oxochromene-3-carboxylic acid
CBNumber: CB5496161
Molecular Formula: C10H6O5
Formula Weight: 206.15
MOL File: 779-27-1.mol

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7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID Property

Melting point:: 261 °C(lit.)
Boiling point:: 474.8±45.0 °C(Predicted)
Density: 1.639±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: DMF: soluble
pka: 7.04 ± 0.02, temperature: 23 °C
form: powder to crystal
color: Yellow solid;Orange solid; Off-white powder
λmax: 386 nm (Buffer pH 10.0); 339 nm (Buffer pH 4.0)
BRN: 384141
Major Application: Carbon-dioxide sensor; chemical sensors based on non-linear optics; monitoring of cationic photopolymerization processes; nanomaterials
Biological Applications: Chemical dosimeter for radiation therapy; detecting bacteria; detecting/sensing hydroxyl radicals; studying nucleic acids; as a substrate for measuring carboxylesterases activity, cellulases activity, β-galactosidases activity, glycosidases activity, glycosyltransferases activity, hydrolases activity, 4-hydroxycinnamate decarboxylases activity, β-lactamases activity, phosphatases activity, sulfatases activity; treating cancer/antitumor activity
InChI: InChI=1S/C10H6O5/c11-6-2-1-5-3-7(9(12)13)10(14)15-8(5)4-6/h1-4,11H,(H,12,13)
InChIKey: LKLWLDOUZJEHDY-UHFFFAOYSA-N
SMILES: C1(=O)OC2=CC(O)=CC=C2C=C1C(O)=O

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 8
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 55155
Product name: 7-Hydroxycoumarin-3-carboxylic acid
Purity: suitable for fluorescence, ≥98.0% (TLC)
Packaging: 100MG
Price: $298
Updated: 2025/07/31

TCI Chemical

Product number: H1352
Product name: 7-Hydroxycoumarin-3-carboxylic Acid
Purity: >98.0%(HPLC)
Packaging: 200mg
Price: $178
Updated: 2025/07/31

TCI Chemical

Product number: H1352
Product name: 7-Hydroxycoumarin-3-carboxylic Acid
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $616
Updated: 2025/07/31

TRC

Product number: H825168
Product name: 7-Hydroxycoumarin-3-carboxylic Acid
Packaging: 1g
Price: $265
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FU66533
Product name: Umbelliferone-3-carboxylic acid
Packaging: 100mg
Price: $50
Updated: 2021/12/16

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7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

Light yellow powder

Uses

7-Hydroxycoumarin-3-carboxylic acid is a pH-indicator that can be immobilized on a support to give a pH sensor.

Uses

Suitable as pH-indicator.

Synthesis

6093-71-6

779-27-1

General procedure for the synthesis of 7-hydroxy-2-oxo-2H-benzopyran-3-carboxylic acid from ethyl 7-hydroxy-2-oxo-2H-benzopyran-3-carboxylate: ethyl 7-hydroxy-2-oxo-2H-benzopyran-3-carboxylate (2.00 g, 8.55 mmol) was dissolved in water (20 ml) at 90 °C and concentrated hydrochloric acid (6 ml) was added slowly. The reaction mixture was refluxed for 8 hours. After the reaction was completed, the reaction solution was cooled to room temperature, the precipitate was collected by filtration and washed with cold water to obtain 7-hydroxy-2-oxo-2H-benzopyran-3-carboxylic acid (1.32 g, 6.41 mmol) as a light red solid in 75% yield.

References

[1] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986, vol. 25, p. 638 - 639
[2] Food Chemistry, 2012, vol. 135, # 4, p. 2872 - 2878
[3] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 5, p. 502 - 506
[4] Chemical Communications, 2017, vol. 53, # 11, p. 1813 - 1816
[5] Patent: CN106279125, 2017, A. Location in patent: Paragraph 0041; 0042

7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

2,4-Dimethoxybenzaldehyde 2,4-Dihydroxybenzaldehyde Potassium carbonate Diethyl ether Aniline Ethyl acetate Hydrochloric acid Diethyl malonate Pyridine 1-Butanol PETROLEUM ETHER Malonic acid

Preparation Products

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7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID Suppliers

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View Lastest Price from 7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID manufacturers

Dideu Industries Group Limited

Product: 7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID 779-27-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-29

Zhuozhou Wenxi import and Export Co., Ltd

Product: 7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID 779-27-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID 779-27-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

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BioChemical

Biochemicals and Reagents

Fluorescent Probes, Labels, Particles and Stains

Detection

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts