JC-1

ChemicalBook > CAS DataBase List > JC-1

Product Name: JC-1
CAS No.: 3520-43-2
Chemical Name: JC-1
Synonyms: JC-1;JC-1, >95%;JC-1 jodide;CBIC2, >95%;ChemicalbookCBIC2,>95%;JC-1[5,5,6,6-Tetrachloro-1,1,3,3;-tetrachloroimidacarbocyanine iodide;inhibit,CBIC-2,JC1,CBIC 2,JC 1,JC-1,Inhibitor;5,5',6,6'-TETRACHLORO-1,1',3,3'-*TETRAETHYBENZIMIDA;1,10,3,30-tetraethyl-5,50,6,60-tetrachloroimidacarbocyanine Iodide
CBNumber: CB5497188
Molecular Formula: C25H27Cl4N4.I
Formula Weight: 652.228
MOL File: 3520-43-2.mol

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JC-1 Property

Melting point:: 275–278 ℃
storage temp.: room temp
solubility: Soluble in methanol, N,N-dimethyl formamide, dimethyl sulfoxide
form: crystals
color: Deep red
λmax: 514nm
Stability:: Store as supplied desiccated at -20°C for up to 2 years from the date of purchase. Solutions in DMSO or distilled water may be stored at 4°C for up to 1 year. DO NOT FREEZE/THAW SOLUTIONS. Sterilize solutions only by filtration, not by autoclaving
Biological Applications: Detectingmitochondrialmembrane potential,ABCB1,ABCC1,and ABCG2 transporters inhibitors,nucleic acid hybridization,prostate cancer; treating cellular death,Alzheimer’s disease; apoptosis assay; cytotoxicity assay; hematotoxicity
Major Application: Langmuir-Blodgett films; lasing systems; nonlinear optical materials; photographic materials1,
InChIKey: FYNNIUVBDKICAX-UHFFFAOYSA-M

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Safety

WGK Germany: 3
F: 10-21

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T4069
Product name: JC-1
Purity: solid
Packaging: 5mg
Price: $632
Updated: 2024/03/01

Cayman Chemical

Product number: 15003
Product name: JC-1
Purity: ≥90%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 15003
Product name: JC-1
Purity: ≥90%
Packaging: 5mg
Price: $302
Updated: 2024/03/01

Cayman Chemical

Product number: 15003
Product name: JC-1
Purity: ≥90%
Packaging: 10mg
Price: $535
Updated: 2024/03/01

TRC

Product number: J211955
Product name: JC-1iodide
Packaging: 2.5mg
Price: $275
Updated: 2021/12/16

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JC-1 Chemical Properties,Usage,Production

Description

JC-1 is a membrane-permeable cationic dye that is used to study mitochondrial integrity in the context of cellular apoptosis. It selectively enters mitochondria and changes fluorescence characteristics with alteration in mitochondrial transmembrane potential (ΔΨm). In healthy cells with a high mitochondrial ΔΨm, JC-1 forms complexes known as J-aggregates, which fluoresce red/orange and may be detected using FL2 settings by flow cytometry. A drop in ΔΨm, a very early event in apoptosis, results in JC-1 monomers, which fluoresce green (FL1 settings on flow cytometers). JC-1 may also be used with fluorescent microscopes or plate readers, using excitation at 520-570 nm and emission at 570-610 nm for J-aggregates and excitation at 485 nm and emission at 535 nm for monomers.

Uses

A dual-emission potential-sensitive probe that can be used to measure mitochondrial membrane potential. JC-1 is a green-fluorescent monomer at low membrane potential. At higher potentials, JC-1 forms red-fluorescent "J-aggregates," which exhibit broad exc

Uses

The cyanine dye JC-1 has been used to determine mitochondrial transmembrane potential.

Definition

ChEBI: 1,1',3,3'-tetraethyl-5,5',6,6'-tetrachloroimidacarbocyanine iodide is a cyanine dye and an organic iodide salt. It has a role as a fluorochrome. It contains a 1,1',3,3'-tetraethyl-5,5',6,6'-tetrachloroimidacarbocyanine.

References

1) Reers et al. (1991), J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential; Biochemistry, 30 4480 2) Smiley et al. (1991), Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1; Proc. Natl. Acad. Sci. USA, 88 3671 3) Lisa et al. (1995), Mitochondrial membrane potential in single living adult rat cardiac myocytes exposed to anoxia or metabolic inhibition; J. Physiol., 486 1 4) Wolosin et al. (2017), Application of JC1 for non-toxic isolation of cells with MDR transporter activity by flow cytometry; PLoS One, 12(4) e0174905 5) Wang et al. (2017), A novel cytoprotective peptide protects mesenchymal stem cells against mitochondrial dysfunction and apoptosis induced by starvation via Nrf2/Sirt3/FoxO3a pathway; J. Transl. Med., 15 33

JC-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from JC-1 manufacturers

Career Henan Chemical Co

Product: JC-1 3520-43-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95--99%
Supply Ability: 1ton
Release date: 2020-01-03

3520-43-2, JC-1Related Search:

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(47729-63-5) 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine iodide

CBIC2, >95%

JC-1, >95%

5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine iodide

JC-1

JC-1,5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethyl-imidacarbocyanine iodide, 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolocarbocyanine iodide, CBIC2(3)

JC-1 jodide

1h-benzimidazolium, 5,6-dichloro-2[3-(5,6-dichloro-1,3-diethyl-1,3-dihydro-2h-benzimidazol-2-ylidene)-1-propenyl]-1,3-diethyl-, Iodide

5,6-dichloro-2-[3-(5,6-dichloro-1,3-diethyl-2-benzimidazolinylidene)propenyl]-1,3-diethylbenzimidazolium Iodide

Benzimidazolium, 5,6-dichloro-2-[3-(5,6-dichloro-1,3diethyl-2-benzimidazolinylidene)propenyl]-1,3-diethyl-, Iodide

Benzimidazolocarbocyanine Iodide, 5,50,6,60-tetrachloro-1,10,3,30-tetraethyl-

Imidacarbocyanine Iodide, 1,10,3,30-tetraethyl-5,50,6,60-tetrachloro-

1,10,3,30-tetraethyl-5,50,6,60-tetrachlorobenzimidazolocarbocyanine Iodide

1,10,3,30-tetraethyl-5,50,6,60-tetrachloroimidacarbocyanine Iodide

5,50,6,60-tetrachloro-1,10,3,30-tetraethylbenzimidazolocarbocyanine Iodide

5,5',6,6'-TETRACHLORO-1,1',3,3'-*TETRAETHYBENZIMIDA

5,5',6,6'-tetrachloro-1,1',3,3'-tetraethyl-imidacarbocyanine iodide

JC-1 [5,5,6,6-Tetrachloro-1,1,3,3-tetraethylbenzimidazolylcarbocyanine iodide] *CAS#: 3520-43-2*

5,6-dichloro-2-[(E)-3-(5,6-dichloro-1,3-diethylbenzimidazol-3-ium-2-yl)prop-2-enylidene]-1,3-diethylbenzimidazole

-tetrachloroimidacarbocyanine iodide

ChemicalbookCBIC2,>95%

JC-1[5,5,6,6-Tetrachloro-1,1,3,3-tetraethylbenzimidazolylcarbocyanine iodide]

JC-1[5,5,6,6-Tetrachloro-1,1,3,3

inhibit,CBIC-2,JC1,CBIC 2,JC 1,JC-1,Inhibitor

3520-43-2

Cyanine