ChemicalBook > CAS DataBase List > NO-1886

NO-1886

Product Name
NO-1886
CAS No.
133208-93-2
Chemical Name
NO-1886
Synonyms
NO-1886;OPF 009;ibrolipim;Ibrolipim NO-1886;NO-1886 Ibrolipim;Ibrolipim, 10 mM in DMSO;Lipoprotein Lipase Activator;4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide;Diethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate;N-(4-bromo-2-cyanophenyl)-4-(diethoxyphosphorylmethyl)benzamide
CBNumber
CB5497355
Molecular Formula
C19H20BrN2O4P
Formula Weight
451.25
MOL File
133208-93-2.mol
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NO-1886 Property

Melting point:
160.5-162.1 °C
Boiling point:
512.5±50.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: ≥20mg/mL
form 
powder
pka
11.51±0.70(Predicted)
color 
off-white to pale yellow
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Safety

Hazard Codes 
Xi,T
Risk Statements 
36/37/38-25
Safety Statements 
26-36-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N1540
Product name
NO-1886
Purity
≥98% (HPLC)
Packaging
5mg
Price
$153
Updated
2025/07/31
Sigma-Aldrich
Product number
N1540
Product name
NO-1886
Purity
≥98% (HPLC)
Packaging
25mg
Price
$301.5
Updated
2025/07/31
Cayman Chemical
Product number
17425
Product name
NO-1886
Purity
≥98%
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
17425
Product name
NO-1886
Purity
≥98%
Packaging
10mg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
17425
Product name
NO-1886
Purity
≥98%
Packaging
25mg
Price
$343
Updated
2024/03/01
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NO-1886 Chemical Properties,Usage,Production

Uses

Antiatherogenic; antiobesity; antidyslipidemia; anticachexia; and antidiabetes/syndrome.

Uses

Lipoprotein Lipase Activator is an inducer of lipoprotein lipase mRNA.

Biological Activity

Lipoprotein lipase activator. Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis. Long-term administration of NO-1886 protects against the development of experimental atherosclerosis in animals.

in vivo

Ibrolipim (NO-1886; 100 mg/kg; oral administration; daily; for 8 weeks; female Sprague-Dawley rats) treatment decreases accumulation of visceral fat and suppresses the increase in body weight resulting from the ovariectomy. Ibrolipim decreases the respiratory quotient and increases expression of the fatty acid translocase messenger RNA (mRNA) in the liver, soleus muscle, and mesenteric fat. Ibrolipim also increases the expression of fatty acid-binding protein mRNA in the liver and soleus muscle and the expression of the uncoupling protein 3 (UCP3) mRNA in the heart, soleus muscle, and mesenteric fat, but not in the brown adipose tissue[2].

Animal Model:Female Sprague-Dawley rats (10-week-old; 200-260 g) with experimental ovariectomy treatment[2]
Dosage:100 mg/kg
Administration:Oral administration; daily; for 8 weeks
Result:Decreased accumulation of visceral fat and suppressed the increase in body weight resulting from the ovariectomy.

NO-1886 Preparation Products And Raw materials

Raw materials

Preparation Products

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NO-1886 Suppliers

China 57 South Korea 1 Switzerland 1 United States 8 Global 67
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
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TargetMol Chemicals Inc.
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+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
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58
Creative Enzymes
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1-516-855-7709
Fax
1-631-938-8127
Email
info@creative-enzymes.com
Country
United States
ProdList
8748
Advantage
58
Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
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Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Creative Enzymes
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Email
info@creative-enzymes.com
Country
United States
ProdList
6057
Advantage
58
MedChemExpress
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Email
sales@medchemexpress.com
Country
United States
ProdList
6398
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58
Riedel-de Haen AG
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Fax
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Country
United States
ProdList
6773
Advantage
87

133208-93-2, NO-1886Related Search:

3-Bromobenzonitrile DIETHYL 4-METHYLBENZYLPHOSPHONATE N-(2-cyanophenyl)benzamide 2-AMINO-5-BROMOBENZONITRILE DIMETHYL(4-METHYLBENZYL)PHOSPHONATE (4-METHYLBENZYL)PHOSPHONIC ACID 4-(DIETHYLPHOSPHONOMETHYL)BENZALDEHYDE NO-1886

  • Ibrolipim NO-1886
  • OPF 009
  • Lipoprotein Lipase Activator
  • N-(4-bromo-2-cyanophenyl)-4-(diethoxyphosphorylmethyl)benzamide
  • NO-1886
  • Diethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate
  • 4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide
  • ibrolipim
  • Diethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate, Ibrolipim, OPF 009
  • Phosphonic acid, [[4-[[(4-bromo-2-cyanophenyl)amino]carbonyl]phenyl]methyl]-, diethyl ester
  • obesity,fatty,inhibit,NO 1886,Ibrolipim,acid,NO1886,Inhibitor,lipoprotein,lipase,Antihyperlipidemic,UCP3,LDL-C,LXRα,HDL-C
  • NO-1886 Ibrolipim
  • Diethyl [[4-[[(4-bromo-2-cyanophenyl)amino]carbonyl]phenyl]methyl]phosphonate
  • Ibrolipim, 10 mM in DMSO
  • 133208-93-2
  • C19H20BrN2O4P
  • Br1C19H20N2O4P1