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PIPAMPERONE DIHYDROCHLORIDE APPROX. 99

Product Name
PIPAMPERONE DIHYDROCHLORIDE APPROX. 99
CAS No.
1893-33-0
Chemical Name
PIPAMPERONE DIHYDROCHLORIDE APPROX. 99
Synonyms
FPA;D02622;R 3345;Propitan;Dipiperon;Dipiperal;piperonil;Piperonyl;Dipiperone;MCN-JR-3345
CBNumber
CB5497461
Molecular Formula
C21H30FN3O2
Formula Weight
375.48
MOL File
1893-33-0.mol
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PIPAMPERONE DIHYDROCHLORIDE APPROX. 99 Property

Melting point:
126°C(lit.)
Boiling point:
563.7±50.0 °C(Predicted)
Density 
1.1017 (estimate)
storage temp. 
Store at -20°C
solubility 
H2O: ~50 mg/mL
form 
powder
pka
16.20±0.20(Predicted)
color 
white
Water Solubility 
81.7mg/L at 25℃
Merck 
14,7455
LogP
2.42
EPA Substance Registry System
Pipamperone (1893-33-0)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
RIDADR 
UN 2811 6.1/PG III
WGK Germany 
1
RTECS 
DW1060000
HS Code 
2933.39.3100
HazardClass 
6.1
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
P2315
Product name
Pipamperone
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$166
Updated
2024/03/01
TCI Chemical
Product number
P2315
Product name
Pipamperone
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$496
Updated
2024/03/01
Chem-Impex
Product number
38191
Product name
Pipamperone,98%(HPLC)
Purity
98%(HPLC)
Packaging
25MG
Price
$146.72
Updated
2021/12/16
ChemScene
Product number
CS-0020023
Product name
Pipamperone
Purity
99.89%
Packaging
5mg
Price
$150
Updated
2021/12/16
AK Scientific
Product number
0155BA
Product name
Pipamperone
Packaging
25mg
Price
$263
Updated
2021/12/16
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PIPAMPERONE DIHYDROCHLORIDE APPROX. 99 Chemical Properties,Usage,Production

Originator

Dipiperon ,Janssen, W. Germany ,1961

Uses

Antipsychotic.

Definition

ChEBI: A member of the class of bipiperidines that is 1,4'-bipiperidine which is substituted at the 1' and 4' positions by 4-(p-fluorophenyl)-4-oxobutyl and carboxamide groups, respectively. A first generation antipsychotic, its properties are gener lly similar to those of haloperidol.

Manufacturing Process

To a stirred solution of 130.4 parts of potassium cyanide and 243.2 parts of piperidine hydrochloride in a mixture of 800 parts of water and 320 parts of ethanol is added portionwise 378 parts of 1-benzyl-4-piperidone. After about one hour a solid starts to precipitate. Stirring is continued for 24 hours. The reaction mixture is filtered and the solid is recrystallized from 1,200 parts of diisopropyl ether. On cooling to room temperature a first crop of 1-benzyl-4cyano-4-piperidinopiperidine melting at about 104°C to 106°C is obtained. By concentrating and further cooling of the mother liquor a second crop of the above compound is obtained.
A mixture of 14.1 parts of 1-benzyl-4-cyano-4-piperidinopiperidine and 40 parts of 90% sulfuric acid is heated on a steam bath for 10 minutes. Without further heating, the mixture is stirred until a temperature of about 20°C is obtained. The mixture is then poured into 150 parts of ice-water and the resultant solution is alkalized with excess ammonium hydroxide solution. The aqueous solution is decanted from the precipitated oil. On treating this oil with 80 parts of acetone, crystallization sets in. After one hour the solid is filtered off and dried to yield 1-benzyl-4-piperidinopiperidine-4-carboxamide melting at about 137.5°C to 140°C.
A mixture of 215 parts of 1-benzyl-4-piperidinopiperidine-4-carboxamide, 1,200 parts of isopropyl alcohol, 1,000 parts of distilled water and 157 parts of hydrogen chloride is debenzylated under atmospheric pressure and at a temperature of about 40°C in the presence of 40 parts of a 10% palladiumon-charcoal catalyst. After the calculated amount of hydrogen is taken up, hydrogenation is stopped. The mixture is filtered and the filtrate is evaporated. The semisolid residue is treated with a mixture of 80 parts of acetone and 80 parts of benzene and evaporated again. The residue is triturated in 200 parts of methanol and filtered, yielding the dihydrochloride of 4-piperidinopiperidine-4-carboxamide melting at about 299°C to 300.8°C with decomposition. A sample of 20 parts of the dihydrochloride is dissolved in 30 parts of water. The aqueous solution is alkalized with 15 parts of 44% sodium hydroxide and stirred for a short time. The solid obtained is filtered off yielding crude product. To separate the free base from organic and inorganic salts, it is extracted overnight in a Soxhlet apparatus with toluene. The toluene extract is evaporated and the solid residue is filtered off, yielding 4piperidinopiperidine-4-carboxamide melting at about 118.5°C to 119.5°C.
To a mixture of 4.1 parts of 4-piperidinopiperidine-4-carboxamide, 6.4 parts of sodium carbonate, and a few crystals of potassium iodide in 100 parts of anhydrous toluene is added dropwise a solution of 5.6 parts of γ-chloro-4fluorobutyrophenone and 40 parts of anhydrous toluene at a temperature of 30°C to 40°C. The mixture is stirred and refluxed for 48 hours. The reaction mixture is cooled and divided between 50 parts of water and 60 parts of chloroform. The combined organic layers - toluene and chloroform - are dried over potassium carbonate, filtered, and evaporated. The oily residue solidifies on treatment with 80 parts of ether. After cooling for 30 minutes at 0°C, there is obtained 1-[γ-(4-fluorobenzoyl)propyl]-4-piperidinopiperidine-4-carboxamide melting at about 124.5°C to 126°C.

brand name

[Name previously used: Floropipamide.].

Therapeutic Function

Antipsychotic

Safety Profile

Poison by ingestion, subcutaneous, and intravenous routes. An experimental teratogen. When heated to decomposition it emits very toxic fumes of Fand Nox.

PIPAMPERONE DIHYDROCHLORIDE APPROX. 99 Preparation Products And Raw materials

Raw materials

Preparation Products

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PIPAMPERONE DIHYDROCHLORIDE APPROX. 99 Suppliers

BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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United States
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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China
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TOKYO CHEMICAL INDUSTRY CO., LTD.
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03-36680489
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03-3668-0520
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Sales-JP@TCIchemicals.com
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Japan
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Shanghai Synmedia Chemical Co., Ltd.
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021-38681880 13817889927
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0213390-8196
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sales@synmedia-chem.com
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GIHI CHEMICALS CO.,LTD
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0086-571-86217390
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0086-571-86217391
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BeiJing TOP Science Bio-Technology Co., Ltd.
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+86-13439059536 +86-15201677815
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BOC Sciences
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United States
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Shanghai YuanYe Biotechnology Co., Ltd.
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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Wuhan FengyaoTonghui Chemical Products Co., Ltd.
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027-87466105 15377573527
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2678564200@qq.com
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China
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17987
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View Lastest Price from PIPAMPERONE DIHYDROCHLORIDE APPROX. 99 manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Piperonyl butoxide 1893-33-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

1893-33-0, PIPAMPERONE DIHYDROCHLORIDE APPROX. 99Related Search:


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  • Dipiperal
  • Dipiperon
  • Dipiperone
  • Floropipamide
  • FPA
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  • [1,4'-Bipiperidine]-4'-carboxamide, 1'-[4-(4-fluorophenyl)-4-oxobutyl]-
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  • 1-(3-(p-fluorobenzoyl)propyl)-4-piperidino-isonipacotamid
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  • 4’-bipiperidine)-4’-carboxamide,1’-(3-(p-fluorobenzoyl)propyl)-(
  • 4’-bipiperidine)-4’-carboxamide,1’-(4-(4-fluorophenyl)-4-oxobutyl)-(
  • 4’-fluoro-4-(4-n-piperidino-4-carbamidopiperidino)butyrophenone
  • 1'-[4-(4-Fluorophenyl)-4-oxobutyl]-[1,4'-bipiperidine]-4'-carboxamide
  • PIPAMPERONE HCL
  • R-3345,Pipamperone,R3345,5-HT Receptor,Serotonin Receptor,inhibit,Dopamine Receptor,Inhibitor,5-hydroxytryptamine Receptor
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  • 1893-33-0
  • C21H30FN3O2