N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97

Product Name: N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97
CAS No.: 102520-97-8
Chemical Name: N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97
Synonyms: tert-Butyl (1-hydroxy-2-Methylpropan-2-yl)carbaMate;N-Boc-2-aMino-2-Methylpropan-1-ol;N-Boc-2-aMino-2-Methyl-1-propanol 97%;N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97;N-Boc-2-amino-2-methyl-1-propanol;tert-Butyl (1-hydroxy-2-methylpropan-2-yl);N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97 USP/EP/BP;N-tert-Butoxycarbonyl-2-amino-2-methyl-1-propanol;ert-butylN-(1-hydroxy-2-methylpropan-2-yl)carbamate;tert-Butyl N-(2-hydroxy-1,1-dimethylethyl)carbamate
CBNumber: CB5498923
Molecular Formula: C9H19NO3
Formula Weight: 189.25
MOL File: 102520-97-8.mol

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N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97 Property

Melting point:: 57-62 °C
Boiling point:: 286.5±23.0 °C(Predicted)
Density: 1.012±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: soluble in Methanol
form: powder to crystal
pka: 12.24±0.46(Predicted)
color: White to Almost white

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 2
HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 657778
Product name: N-Boc-2-amino-2-methyl-1-propanol
Purity: 97%
Packaging: 1g
Price: $31
Updated: 2023/06/20

Sigma-Aldrich

Product number: 657778
Product name: N-Boc-2-amino-2-methyl-1-propanol
Purity: 97%
Packaging: 5g
Price: $132
Updated: 2023/06/20

TCI Chemical

Product number: B6025
Product name: N-tert-Butoxycarbonyl-2-amino-2-methyl-1-propanol
Packaging: 1G
Price: $27
Updated: 2025/07/31

TCI Chemical

Product number: B6025
Product name: N-tert-Butoxycarbonyl-2-amino-2-methyl-1-propanol
Packaging: 5G
Price: $60
Updated: 2025/07/31

TRC

Product number: B809918
Product name: tert-Butyl(1-Hydroxy-2-methylpropan-2-yl)carbamate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

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N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97 Chemical Properties,Usage,Production

Uses

tert-Butyl (1-Hydroxy-2-methylpropan-2-yl)carbamate is used in preparation of diamine derivatives as KCa3.1 potassium channel inhibitors.

Synthesis

24424-99-5

124-68-5

102520-97-8

General procedure for the synthesis of 2-(Boc-amino)-2-methyl-1-propanol from di-tert-butyl dicarbonate and 2-amino-2-methyl-1-propanol: 230.4 mL of di-tert-butyl dicarbonate (1.00 mol) was added slowly and dropwise to a solution of di-tert-butyl dicarbonate (1.00 mol) at room temperature containing 98.05 g of 2-amino-2-methyl-1-propanol (1.10 mol) and 154 mL of triethylamine ( 1.10 mol) in a solution of dichloromethane (500 mL), and the titration process was continued for 20 minutes. The reaction mixture was continued to be stirred at room temperature for 2.5 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and the residue was diluted with 10% aqueous citric acid solution and subsequently extracted with ethyl acetate. The organic layers were combined, washed sequentially with water and saturated brine and dried over anhydrous magnesium sulfate. The desiccant was removed by filtration and the solvent was evaporated under reduced pressure to give 189.25 g of the crude product 2-(Boc-amino)-2-methyl-1-propanol in quantitative yield. The product was a colorless solid.1H NMR (CDCl3, 400 MHz) δ: 4.64 (br s, 1H), 4.01 (br s, 1H), 3.59 (d, 2H, J = 6.3 Hz), 1.43 (s, 9H), 1.25 (s, 6H).

References

[1] Journal of Organic Chemistry, 2000, vol. 65, # 20, p. 6368 - 6380
[2] Patent: EP2036896, 2009, A1. Location in patent: Page/Page column 149
[3] Journal of Organic Chemistry, 2005, vol. 70, # 4, p. 1188 - 1197
[4] Journal of Chemical Research, 2013, vol. 37, # 12, p. 757 - 760
[5] Patent: US6140326, 2000, A

N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97 Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97 Suppliers

Americas 1 China 119 Europe 1 India 2 Japan 1 Switzerland 1 United Kingdom 1 United States 8 Global 134

Sichuan Tongsheng Amino acids Co.,Ltd.

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View Lastest Price from N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97 manufacturers

Career Henan Chemical Co

Product: N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97 102520-97-8
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%MIN
Supply Ability: ASK
Release date: 2020-01-09

102520-97-8, N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97Related Search:

1-TERT-BUTOXYCARBONYLAMINO-CYCLOHEXANECARBOXYLIC ACID Boc-Aib-OH 2-(TERT-BUTOXYCARBONYLAMINO)-1,2,3,4-TETRAHYDRONAPHTHALENE-2-CARBOXYLIC ACID BOC-N,2-DIMETHYLALANINE 1-N-Boc-Aminocyclopentanecarboxylic acid 1-BOC-3-AMINOPIPERIDINE N-BOC-2-AMINOINDANE-2-CARBOXYLIC ACID 2-(N-BOC-AMINO)-5-(N-FMOC-AMINO)INDAN-2-CARBOXYLIC ACID BOC-ALPHA-METHYL-3-METHOXY-DL-PHENYLALANINE BOC-AIB-OSU BOC-(R)-<ALPHA>-ALLYL-PRO-OH BOC-ALPHA-METHYL-L-PHE BOC-ALPHA-ME-DL-VAL-OH 1-(BOC-AMINO)-4-METHYL-CYCLOHEXENE(3)-1-CARBOXYLIC ACID N-BOC-D,L-1-AMINOINDANE-1-CARBOXYLIC ACID BOC-ALPHA-METHYL-L-TYR (S)-N-BOC-2-AMINO-2-CYCLOHEXYL-PROPANOIC ACID 2-TERT-BUTOXYCARBONYLAMINO-2-ETHYL-BUTYRIC ACID

1,1-Dimethylethyl (2-hydroxy-1,1-dimethylethyl)carbamate, 2-Hydroxy-1,1-dimethylethyl)carbamic acid 1,1-dimethylethyl ester, (2-Hydroxy-1,1-dimethylethyl)carbamic acid tert-butyl ester

N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97

N-Boc-2-aMino-2-Methyl-1-propanol 97%

Carbamic acid,N-(2-hydroxy-1,1-dimethylethyl)-, 1,1-dimethylethyl ester

tert-Butyl (1-hydroxy-2-Methylpropan-2-yl)carbaMate

N-Boc-2-aMino-2-Methylpropan-1-ol

tert-Butyl N-(2-hydroxy-1,1-dimethylethyl)carbamate

tert-Butyl (1-hydroxy-2-methylpropan-2-yl)

tert-butyl N-(1-hydroxy-2-methylpropan-2-yl)carbamate

N-(1-hydroxy-2-methylpropan-2-yl)carbamic acid tert-butyl ester

ert-butylN-(1-hydroxy-2-methylpropan-2-yl)carbamate

N-tert-Butoxycarbonyl-2-amino-2-methyl-1-propanol

N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97 USP/EP/BP

N-(2-hydroxy-1,1-dimethylethyl)-, 1,1-dimethylethyl ester

<i>N</i>-Boc-2-amino-2-methyl-1-propanol

102520-97-8