ChemicalBook > CAS DataBase List > N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97

N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97

Product Name
N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97
CAS No.
102520-97-8
Chemical Name
N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97
Synonyms
tert-Butyl (1-hydroxy-2-Methylpropan-2-yl)carbaMate;N-Boc-2-aMino-2-Methylpropan-1-ol;N-Boc-2-aMino-2-Methyl-1-propanol 97%;N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97;N-Boc-2-amino-2-methyl-1-propanol;tert-Butyl (1-hydroxy-2-methylpropan-2-yl);N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97 USP/EP/BP;N-tert-Butoxycarbonyl-2-amino-2-methyl-1-propanol;ert-butylN-(1-hydroxy-2-methylpropan-2-yl)carbamate;tert-Butyl N-(2-hydroxy-1,1-dimethylethyl)carbamate
CBNumber
CB5498923
Molecular Formula
C9H19NO3
Formula Weight
189.25
MOL File
102520-97-8.mol
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N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97 Property

Melting point:
57-62 °C
Boiling point:
286.5±23.0 °C(Predicted)
Density 
1.012±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
soluble in Methanol
form 
powder to crystal
pka
12.24±0.46(Predicted)
color 
White to Almost white
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
2
HS Code 
2924297099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
657778
Product name
N-Boc-2-amino-2-methyl-1-propanol
Purity
97%
Packaging
1g
Price
$31
Updated
2023/06/20
Sigma-Aldrich
Product number
657778
Product name
N-Boc-2-amino-2-methyl-1-propanol
Purity
97%
Packaging
5g
Price
$132
Updated
2023/06/20
TCI Chemical
Product number
B6025
Product name
N-tert-Butoxycarbonyl-2-amino-2-methyl-1-propanol
Packaging
1G
Price
$27
Updated
2025/07/31
TCI Chemical
Product number
B6025
Product name
N-tert-Butoxycarbonyl-2-amino-2-methyl-1-propanol
Packaging
5G
Price
$60
Updated
2025/07/31
TRC
Product number
B809918
Product name
tert-Butyl(1-Hydroxy-2-methylpropan-2-yl)carbamate
Packaging
100mg
Price
$60
Updated
2021/12/16
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N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97 Chemical Properties,Usage,Production

Uses

tert-Butyl (1-Hydroxy-2-methylpropan-2-yl)carbamate is used in preparation of diamine derivatives as KCa3.1 potassium channel inhibitors.

Synthesis

24424-99-5

124-68-5

102520-97-8

General procedure for the synthesis of 2-(Boc-amino)-2-methyl-1-propanol from di-tert-butyl dicarbonate and 2-amino-2-methyl-1-propanol: 230.4 mL of di-tert-butyl dicarbonate (1.00 mol) was added slowly and dropwise to a solution of di-tert-butyl dicarbonate (1.00 mol) at room temperature containing 98.05 g of 2-amino-2-methyl-1-propanol (1.10 mol) and 154 mL of triethylamine ( 1.10 mol) in a solution of dichloromethane (500 mL), and the titration process was continued for 20 minutes. The reaction mixture was continued to be stirred at room temperature for 2.5 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and the residue was diluted with 10% aqueous citric acid solution and subsequently extracted with ethyl acetate. The organic layers were combined, washed sequentially with water and saturated brine and dried over anhydrous magnesium sulfate. The desiccant was removed by filtration and the solvent was evaporated under reduced pressure to give 189.25 g of the crude product 2-(Boc-amino)-2-methyl-1-propanol in quantitative yield. The product was a colorless solid.1H NMR (CDCl3, 400 MHz) δ: 4.64 (br s, 1H), 4.01 (br s, 1H), 3.59 (d, 2H, J = 6.3 Hz), 1.43 (s, 9H), 1.25 (s, 6H).

References

[1] Journal of Organic Chemistry, 2000, vol. 65, # 20, p. 6368 - 6380
[2] Patent: EP2036896, 2009, A1. Location in patent: Page/Page column 149
[3] Journal of Organic Chemistry, 2005, vol. 70, # 4, p. 1188 - 1197
[4] Journal of Chemical Research, 2013, vol. 37, # 12, p. 757 - 760
[5] Patent: US6140326, 2000, A

N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97 Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97 Suppliers

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View Lastest Price from N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97 manufacturers

Career Henan Chemical Co
Product
N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97 102520-97-8
Price
US $2.00/KG
Min. Order
1g
Purity
98%MIN
Supply Ability
ASK
Release date
2020-01-09

102520-97-8, N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97Related Search:

1-TERT-BUTOXYCARBONYLAMINO-CYCLOHEXANECARBOXYLIC ACID Boc-Aib-OH 2-(TERT-BUTOXYCARBONYLAMINO)-1,2,3,4-TETRAHYDRONAPHTHALENE-2-CARBOXYLIC ACID BOC-N,2-DIMETHYLALANINE 1-N-Boc-Aminocyclopentanecarboxylic acid 1-BOC-3-AMINOPIPERIDINE N-BOC-2-AMINOINDANE-2-CARBOXYLIC ACID 2-(N-BOC-AMINO)-5-(N-FMOC-AMINO)INDAN-2-CARBOXYLIC ACID BOC-ALPHA-METHYL-3-METHOXY-DL-PHENYLALANINE BOC-AIB-OSU BOC-(R)-<ALPHA>-ALLYL-PRO-OH BOC-ALPHA-METHYL-L-PHE BOC-ALPHA-ME-DL-VAL-OH 1-(BOC-AMINO)-4-METHYL-CYCLOHEXENE(3)-1-CARBOXYLIC ACID N-BOC-D,L-1-AMINOINDANE-1-CARBOXYLIC ACID BOC-ALPHA-METHYL-L-TYR (S)-N-BOC-2-AMINO-2-CYCLOHEXYL-PROPANOIC ACID 2-TERT-BUTOXYCARBONYLAMINO-2-ETHYL-BUTYRIC ACID

  • 1,1-Dimethylethyl (2-hydroxy-1,1-dimethylethyl)carbamate, 2-Hydroxy-1,1-dimethylethyl)carbamic acid 1,1-dimethylethyl ester, (2-Hydroxy-1,1-dimethylethyl)carbamic acid tert-butyl ester
  • N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97
  • N-Boc-2-aMino-2-Methyl-1-propanol 97%
  • Carbamic acid,N-(2-hydroxy-1,1-dimethylethyl)-, 1,1-dimethylethyl ester
  • tert-Butyl (1-hydroxy-2-Methylpropan-2-yl)carbaMate
  • N-Boc-2-aMino-2-Methylpropan-1-ol
  • tert-Butyl N-(2-hydroxy-1,1-dimethylethyl)carbamate
  • tert-Butyl (1-hydroxy-2-methylpropan-2-yl)
  • tert-butyl N-(1-hydroxy-2-methylpropan-2-yl)carbamate
  • N-(1-hydroxy-2-methylpropan-2-yl)carbamic acid tert-butyl ester
  • ert-butylN-(1-hydroxy-2-methylpropan-2-yl)carbamate
  • N-tert-Butoxycarbonyl-2-amino-2-methyl-1-propanol
  • N-BOC-2-AMINO-2-METHYL-1-PROPANOL 97 USP/EP/BP
  • N-(2-hydroxy-1,1-dimethylethyl)-, 1,1-dimethylethyl ester
  • <i>N</i>-Boc-2-amino-2-methyl-1-propanol
  • 102520-97-8