ChemicalBook > CAS DataBase List > 2,3-DIFLUORO-6-NITROANISOLE

2,3-DIFLUORO-6-NITROANISOLE

Product Name
2,3-DIFLUORO-6-NITROANISOLE
CAS No.
66684-60-4
Chemical Name
2,3-DIFLUORO-6-NITROANISOLE
Synonyms
Benzene,1,2-difluoro-3-Methoxy-4-nitro-
CBNumber
CB5501188
Molecular Formula
C7H5F2NO3
Formula Weight
189.12
MOL File
66684-60-4.mol
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2,3-DIFLUORO-6-NITROANISOLE Property

Boiling point:
78-79/20mm
Density 
1.414±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
Appearance
Light brown to brown Liquid
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Safety

Hazard Codes 
Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36/37/39
Hazard Note 
Irritant
HS Code 
2909309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D448523
Product name
1,2-Difluoro-3-methoxy-4-nitrobenzene
Packaging
500mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD70353
Product name
2,3-Difluoro-6-nitroanisole
Packaging
10g
Price
$70
Updated
2021/12/16
SynQuest Laboratories
Product number
4654-3-63
Product name
2,3-Difluoro-6-nitroanisole
Purity
98%
Packaging
25g
Price
$105
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0017458
Product name
2,3-DIFLUORO-6-NITROANISOLE
Purity
95.00%
Packaging
1G
Price
$117.6
Updated
2021/12/16
AK Scientific
Product number
V7192
Product name
1,2-Difluoro-3-methoxy-4-nitrobenzene
Packaging
1g
Price
$14
Updated
2021/12/16
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2,3-DIFLUORO-6-NITROANISOLE Chemical Properties,Usage,Production

Uses

1,2-Difluoro-3-methoxy-4-nitrobenzene

Synthesis

82419-26-9

74-88-4

66684-60-4

General procedure for the synthesis of 2,3-difluoro-6-nitroanisole from 2,3-difluoro-6-nitrophenol and iodomethane: Intermediate B92: 3-fluoro-4-[4-(1-methylethyl)-1-piperazinyl]-2-(methoxy)aniline. Step A/Intermediate B93: 1,2-difluoro-3-(methoxy)-4-nitrobenzene. To a solution of 2,3-difluoro-6-nitrophenol (15.01 g, 85.8 mmol) in anhydrous dimethylformamide (120 mL) was sequentially added potassium carbonate (16.6 g, 120 mmol) and iodomethane (6.63 mL, 107 mmol). The reaction mixture was stirred at room temperature overnight. On the following day, the reaction mixture was poured into water and extracted twice with ether. The organic layers were combined, washed twice with 5% lithium chloride aqueous solution and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give 1,2-difluoro-3-(methoxy)-4-nitrobenzene as a yellow oil (14.7 g, 91% yield). 1H NMR (400 MHz, CDCl3) δ ppm: 4.13 (s, 3H), 7.00 (td, J = 9.07, 7.15 Hz, 1H), 7.67 (ddd, J = 9.35, 5.32, 2.20 Hz, 1H).

References

[1] Patent: WO2009/20990, 2009, A1. Location in patent: Page/Page column 126
[2] Patent: US4997943, 1991, A

2,3-DIFLUORO-6-NITROANISOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3-DIFLUORO-6-NITROANISOLE Suppliers

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View Lastest Price from 2,3-DIFLUORO-6-NITROANISOLE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2,3-Difluoro-6-nitroanisole 66684-60-4
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
100 tons
Release date
2020-01-10

66684-60-4, 2,3-DIFLUORO-6-NITROANISOLERelated Search:

Benzene, 1,2,5-trifluoro-3-methoxy- 2-Chloro-1-(difluoromethoxy)-3-nitro-benzene 3-bromo-5-methyl-4-nitroanisole 1-Bromo-2-(difluoromethoxy)-4,5-difluoro-benzene 3-bromo-5-(difluoromethoxy)anisole 1-(difluoromethoxy)-2-fluoro-4-iodobenzene 3-(DIFLUOROMETHOXY)IODOBENZENE 1-broMo-2-Methoxy-4-(trifluoroMethoxy)benzene 6-Fluoro-2-aminophenol 2-Fluoro-6-nitrophenol 2-Acetonyloxy-3,4-difluoro nitrobenzene 3,4-Difluoro-2-methoxyaniline 2,3-DIFLUORO-6-NITROPHENOL 2,3-Difluoro-6-nitroanisole 2,3-DIFLUORO-6-NITROANISOLE 5-Fluoro-2-methoxyaniline 2-Fluoro-6-nitroanisole 6-AMINO-2 3-DIFLUOROPHENOL

  • Benzene,1,2-difluoro-3-Methoxy-4-nitro-
  • 66684-60-4