5-Fluoro-2-methoxyaniline
- Product Name
- 5-Fluoro-2-methoxyaniline
- CAS No.
- 1978-39-8
- Chemical Name
- 5-Fluoro-2-methoxyaniline
- Synonyms
- 5-fluoro-o-anisidine;2-amino-4-fluoroanisole;5-Fluoro-2-methoxyaniline;5-Fluoro-o-anisidine (NH2=1);5-fluoro-2-methoxybenzenamine;5-Fluoro-2-methoxyaniline 97%;5-Fluoro-2-methoxyaniline, JRD;BenzenaMine,5-fluoro-2-Methoxy-;2-amino-4-fluoro-1-methoxybenzene;2-Amino-4-fluoroanisole, 5-Fluoro-o-anisidine
- CBNumber
- CB0967598
- Molecular Formula
- C7H8FNO
- Formula Weight
- 141.14
- MOL File
- 1978-39-8.mol
5-Fluoro-2-methoxyaniline Property
- Melting point:
- 3 °C
- Boiling point:
- 90 °C/760 mmHg
- Density
- 1.1981 g/mL at 25 °C
- refractive index
- n20/D 1.5438
- Flash point:
- 109 °C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- clear liquid
- pka
- 3.52±0.10(Predicted)
- color
- Colorless to Light yellow to Light orange
- CAS DataBase Reference
- 1978-39-8
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- RIDADR
- UN 2810 6.1/PG III
- WGK Germany
- 3
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 2921420090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H302Harmful if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P309IF exposed or if you feel unwell:
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 683310
- Product name
- 5-Fluoro-2-methoxyaniline
- Purity
- 97%
- Packaging
- 1g
- Price
- $49.7
- Updated
- 2023/06/20
- Product number
- F0614
- Product name
- 5-Fluoro-2-methoxyaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $72
- Updated
- 2025/07/31
- Product number
- F592250
- Product name
- 5-Fluoro-2-methoxyaniline
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- F592250
- Product name
- 5-Fluoro-2-methoxyaniline
- Packaging
- 25g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- 081107
- Product name
- 5-Fluoro-2-methoxyaniline
- Purity
- 97%
- Packaging
- 25g
- Price
- $185
- Updated
- 2021/12/16
5-Fluoro-2-methoxyaniline Chemical Properties,Usage,Production
Uses
5-Fluoro-2-methoxyaniline was used in the study of structure-activity relationship to discover selective inhibitors of p97 ATPase.
Synthesis
445-83-0
1978-39-8
General procedure for the synthesis of 2-methoxy-5-fluoroaniline from 2-nitro-4-fluoroanisole: 4-fluoro-2-nitroanisole (85 g, 0.50 mol) was dissolved in methanol (300 mL) and palladium-carbon catalyst (10%, 8 g) was added. The reaction was stirred under hydrogen atmosphere for 15 hours. After completion of the reaction, the catalyst was removed by filtration, and the filtrate was concentrated to dryness to obtain the crude product 2-methoxy-5-fluoroaniline (61.5 g, 0.436 mol, 87% yield), which could be directly used in the next reaction without further purification.
References
[1] Collection of Czechoslovak Chemical Communications, 1982, vol. 47, # 1, p. 72 - 87
[2] Patent: WO2005/26137, 2005, A2. Location in patent: Page/Page column 231
[3] Journal of Organic Chemistry, 1951, vol. 16, p. 1345,1348
[4] Journal of the American Chemical Society, 1959, vol. 81, p. 94,95, 97
[5] Journal of Organic Chemistry, 1952, vol. 17, p. 229,230
5-Fluoro-2-methoxyaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Fluoro-2-methoxyaniline manufacturers
- Product
- 5-Fluoro-2-methoxyaniline 1978-39-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-10
- Product
- 5-Fluoro-2-methoxyaniline 1978-39-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-17
- Product
- 5-Fluoro-o-anisidine 1978-39-8
- Price
- US $50.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- g-kg-tons,free sample is available
- Release date
- 2024-01-03