6-Fluoro-2-aminophenol
- Product Name
- 6-Fluoro-2-aminophenol
- CAS No.
- 53981-25-2
- Chemical Name
- 6-Fluoro-2-aminophenol
- Synonyms
- 6-Fluoro-2-aminophen;6-Fluoro-2-Aminophenol;2-Amino-6-fluorophenol97%;Phenol, 2-amino-6-fluoro-;2-Amino-6-fluorophenol 97%;3-Fluoro-2-hydroxyaniline 97%
- CBNumber
- CB71459457
- Molecular Formula
- C6H6FNO
- Formula Weight
- 127.12
- MOL File
- 53981-25-2.mol
6-Fluoro-2-aminophenol Property
- Boiling point:
- 215.7±25.0 °C(Predicted)
- Density
- 1.347±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 8.50±0.10(Predicted)
- form
- Solid
- Appearance
- Brown to black Solid
- InChI
- InChI=1S/C6H6FNO/c7-4-2-1-3-5(8)6(4)9/h1-3,9H,8H2
- InChIKey
- MDIAVSZFIQWYST-UHFFFAOYSA-N
- SMILES
- C1(O)=C(F)C=CC=C1N
Safety
- RIDADR
- 2811
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 2921420090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A609590
- Product name
- 2-Amino-6-fluorophenol
- Packaging
- 5g
- Price
- $290
- Updated
- 2021/12/16
- Product number
- FA17661
- Product name
- 2-Amino-6-fluorophenol
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 073498
- Product name
- 6-Fluoro-2-aminophenol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $43
- Updated
- 2021/12/16
- Product number
- 4656-3-08
- Product name
- 2-Amino-6-fluorophenol
- Purity
- 97%
- Packaging
- 1g
- Price
- $52
- Updated
- 2021/12/16
- Product number
- FA17661
- Product name
- 2-Amino-6-fluorophenol
- Packaging
- 2g
- Price
- $70
- Updated
- 2021/12/16
6-Fluoro-2-aminophenol Chemical Properties,Usage,Production
Chemical Properties
Purple crystals
Uses
A metabolite of halogenated aniline.
Synthesis
1526-17-6
53981-25-2
The general procedure for the synthesis of 6-fluoro-2-aminophenol from 2-fluoro-6-nitrophenol was as follows: 2-fluoro-6-nitrophenol (6.37 mmol, 1.00 g) was dissolved in methanol (100 mL), and 10% activated charcoal-loaded palladium catalyst (10% by weight of 2-fluoro-6-nitrophenol, 0.10 g) was added. The reaction system was displaced first with argon and then with hydrogen, each displacement lasting 15 min, during which magnetic stirring was maintained. Subsequently, the reaction was carried out at atmospheric pressure (using a hydrogen balloon) and under hydrogen atmosphere for 1 hour. Upon completion of the reaction, the gas in the reaction vessel was again replaced with argon for 15 minutes. The reaction mixture was filtered through a diatomaceous earth pad and washed with methanol (50 mL). The filtrate was concentrated under vacuum to give a red solid product. Purification by silica gel column chromatography (eluent ratio 1:1 hexane/chloroform) gave a white crystalline solid in 87% yield.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 15, p. 3521 - 3525
[2] Patent: JP2016/124812, 2016, A. Location in patent: Paragraph 0115
[3] Patent: US2010/298334, 2010, A1. Location in patent: Page/Page column 46
[4] Patent: WO2005/118561, 2005, A1. Location in patent: Page/Page column 25
[5] Patent: US2005/124667, 2005, A1. Location in patent: Page/Page column 17
6-Fluoro-2-aminophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Fluoro-2-aminophenol manufacturers
- Product
- 6-Fluoro-2-aminophenol 53981-25-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-02