ChemicalBook > CAS DataBase List > 5-Amino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxamide

5-Amino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxamide

Product Name: 5-Amino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxamide
CAS No.: 99519-84-3
Chemical Name: 5-Amino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxamide
Synonyms: L-651582;NSC 609974;MERCK L651582;carboxyamido-triazole;Carboxyamidotriazole >=98% (HPLC);5-amino-1-[4-(4-chlorobenzoyl)-3,5-dichlorobenzyl]-1,2,3-triazole-4-carboxamide;5-Amino-1-[4-(4-chlorobenzoyl)-3,5-dichlorobenzyl]-1H-1,2,3-triazole-4-carboxamide;1-[3,5-Dichloro-4-(4-chlorobenzoyl)benzyl]-5-amino-1H-1,2,3-triazole-4-carboxamide;5-Amino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxamide;1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE-5-AMINO-1-[[3,5-DICHLORO-4-(4-CHLOROBENZOYL)PHENYL]METHYL]
CBNumber: CB5501698
Molecular Formula: C17H12Cl3N5O2
Formula Weight: 424.67
MOL File: 99519-84-3.mol

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5-Amino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxamide Property

Melting point:: 200-202 °C
Boiling point:: 685.5±65.0 °C(Predicted)
Density: 1.65±0.1 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: DMSO: soluble10mg/mL (clear solution)
form: powder
pka: 14.16±0.50(Predicted)
color: white to beige

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0408
Product name: Carboxyamidotriazole
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $102
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0408
Product name: Carboxyamidotriazole
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $273
Updated: 2025/07/31

Cayman Chemical

Product number: 28732
Product name: Carboxyamidotriazole
Packaging: 5mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 28732
Product name: Carboxyamidotriazole
Packaging: 25mg
Price: $414
Updated: 2024/03/01

Cayman Chemical

Product number: 28732
Product name: Carboxyamidotriazole
Packaging: 10mg
Price: $187
Updated: 2024/03/01

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5-Amino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxamide Chemical Properties,Usage,Production

Uses

Carboxyamidotriazole is an orally active calcium channel blocker. Carboxyamidotriazole also exhibits inhibition of pro-inflammatory cytokines in tumor associated macrophages as potential anti-cancer m echanism.

Biological Activity

Orally active Ca 2+ channel blocker; inhibits K + - and carbachol-stimulated Ca 2+ influx (IC 50 values are 500 and 935 nM respectively). Exhibits antiproliferative, antiangiogenic and antimetastatic activity in vivo and displays selectivity towards numerous mismatch repair-deficient tumor cell lines in vitro .

in vivo

Carboxyamidotriazole (30 mg/kg; i.g.; daily; 19 days) combined with 2-deoxyglucose retards the growth of LLC tumors in C57BL/6 mice^[4].
Carboxyamidotriazole (10-40 mg/kg; i.g.; once daily; from day 12 to day 26 after arthritis induction) reduces the severity of arthritis, inhibits hind paw swelling, decreases the infiltration of joint pathological inflammatory cells in the adjuvant arthritis model of Lewis rats induced by complete Freund's adjuvant^[9].
Carboxyamidotriazole (30 mg/kg; i.g.; once daily; from day 7 to day 29 after inoculation of tumor cells) inhibits tumor growth, enhances the weights of gastrocnemius muscle and epididymal adipose tissue in the C57BL/6J mouse model inoculated with Lewis lung carcinoma cells^[10].
Carboxyamidotriazole (30 mg/kg; i.g.; once daily; for 29 days) combined with low-dose Sorafenib (HY-10201) synergistically inhibits tumor growth in the C57BL/6J mouse model inoculated with Lewis lung carcinoma cells^[11].
Carboxyamidotriazole (20 mg/kg; i.g.; once daily) combined with 1-MT or DMF, increases the number of CD8⁺ T cells in tumor-infiltrating lymphocytes (TILs), enhances the anti-tumor immune response of T cells, inhibits tumor growth, and prolongs the survival in the C57BL/6, BALB/c or RAG1 KO mouse models inoculated with B16, C26, 4T1 or B16-OVA tumor cells^[12].
Carboxyamidotriazole (40 mg/kg, p.o., once daily, 14 days) reduces Bleomycin (HY-108345)-induced lung injury in mice^[13].

Animal Model:	C57BL/6 mice (weight: 18-22 g) + LLC xenograft model^[4]
Dosage:	Carboxyamidotriazole (30 mg/kg, dissolved in PEG 400), 2-DG (450 mg/kg)
Administration:	Carboxyamidotriazole was administered intragastrically daily, and 2-DG was administered intraperitoneally daily for 19 days
Result:	Caused no obvious changes in the animal body weight and behaviors. Resulted in slower tumor growth than in the groups treated with Carboxyamidotriazole or 2-DG alone.

Animal Model:	C57BL/6J male mice (weight: 18-22 g, 6-8 weeks old) inoculated with Lewis lung carcinoma cells^[11]
Dosage:	30 mg/kg
Administration:	Intragastric administration, once daily, 29 days
Result:	Synergistically inhibited tumor growth in combination with low-dose Sorafenib. Showed comparable efficacy to high-dose Sorafenib monotherapy. Alleviated weight loss during cancer progression and inhibited NANOG expression in tumor tissues.

storage

Store at +4°C

5-Amino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Amino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxamide Suppliers

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View Lastest Price from 5-Amino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxamide manufacturers

Henan Fengda Chemical Co., Ltd

Product: 5-Amino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxamide 99519-84-3
Price: US $8.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

Henan Fengda Chemical Co., Ltd

Product: 5-Amino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxamide 99519-84-3
Price: US $8.00-1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

99519-84-3, 5-Amino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxamideRelated Search:

Benzoyl peroxide Chlorantraniliprole Benzyl chloride Benzyl acetate Sodium carboxymethyl cellulose 1H-Benzotriazole N,N-Dimethylformamide Benzyl alcohol 1,2,4-Triazole Formamide Benzyl benzoate Benzyl 4-ISOCYANATO-1-(TRIFLUOROACETYL)PIPERIDINE 2-Chloro-4-methylbenzaldehyde 2',6'-Dichloroacetophenone 3-Chloro-4-methylbenzylamine 2,4'-Dichlorobenzophenone 4-METHYL-1-PHENYLMETHYL-1H-1,2,3-TRIAZOLE

5-Amino-1-[3,5-dichloro-4-(4-chlorobenzoyl)benzyl]-1H-[1,2,3]triazole-4-carboxylic acid amide

1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE-5-AMINO-1-[[3,5-DICHLORO-4-(4-CHLOROBENZOYL)PHENYL]METHYL]

carboxyamido-triazole

5-Amino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxamide

1-[3,5-Dichloro-4-(4-chlorobenzoyl)benzyl]-5-amino-1H-1,2,3-triazole-4-carboxamide

5-Amino-1-[4-(4-chlorobenzoyl)-3,5-dichlorobenzyl]-1H-1,2,3-triazole-4-carboxamide

L-651582

carboxyaMido-triazole(5-AMino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxaMide)

Merck L651582 5-aMino-1-[3,5-dichloro-4-(4-chloro-benzoyl)-benzyl]-1H-[1,2,3]triazole-4-carboxylic acid aMide

MERCK L651582

NSC 609974

5-amino-1-[4-(4-chlorobenzoyl)-3,5-dichlorobenzyl]-1,2,3-triazole-4-carboxamide

5-AMINO-1-[[3,5-DICHLORO-4-(4-CHLORO-BENZOYL)-PHENYL]METHYL]-1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE

5-Amino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxamide?, Carboxyamidotriazole

Carboxyamidotriazole >=98% (HPLC)

99519-84-3

C17H12Cl3N5O2