(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST

Product Name: (+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST
CAS No.: 5652-28-8
Chemical Name: (+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST
Synonyms: 2-AP3;Alanine, 3-phosphono-;2-Amino-3-phosphonopropionic acid;(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST
CBNumber: CB5503036
Molecular Formula: C3H8NO5P
Formula Weight: 169.07
MOL File: 5652-28-8.mol

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(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST Property

Boiling point:: 481.6±55.0 °C(Predicted)
Density: 1.763±0.06 g/cm3(Predicted)
solubility: PBS (pH 7.2): 2 mg/ml
form: White powder.
pka: 1.22±0.10(Predicted)
color: White to off-white

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Safety

HS Code: 2931499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13852
Product name: DL-AP3
Purity: ≥95%
Packaging: 50mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 13852
Product name: DL-AP3
Purity: ≥95%
Packaging: 100mg
Price: $68
Updated: 2024/03/01

TRC

Product number: A627553
Product name: DL-2-Amino-3-phosphonopropionicAcid(AP3)
Packaging: 100mg
Price: $75
Updated: 2021/12/16

TRC

Product number: A627553
Product name: DL-2-Amino-3-phosphonopropionicAcid(AP3)
Packaging: 250mg
Price: $160
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 38685
Product name: DL-2-Amino-3-phosphonopropionic acid
Packaging: 250mg
Price: $650
Updated: 2021/12/16

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(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST Chemical Properties,Usage,Production

Description

Metabotropic glutamate receptors (mGluR1-8) are G protein-coupled receptors that function to modulate brain excitatory signaling via presynaptic, postsynaptic, and glial mechanisms. DL-AP3 is a competitive mGluR1 antagonist that demonstrates a K_i value of 298 μM and an IC₅₀ value of 1mM for rat mGluR1α when challenged with glutamate. DL-AP3 can antagonize excitatory amino acid-induced phosphoinositide hydrolysis, induce Ca²⁺ mobilization in rat hippocampal slices, and inhibit phosphoserine phosphatase in rat brain cortex. At concentrations from 10-300 μM DL-AP3 has been used to characterize the role of mGluR in long-term potentiation in the hippocampus in a model of learning and memory, the release of glutamate in Parkinson’s disease, and the increased activity of mGluR implicated in fragile X syndrome.

Uses

DL-2-Amino-3-phosphonopropionic acid (AP3) is an inhibitor of phosphoserine phosphatase and mGluR. Also known as the antagonist of a receptor that is coupled to phosphoinositide metabolism in brain slices. D,L-2-Amino-3-phosphonopropionic acid is also an inhibitor of metabotropic glutamate receptors in rat brain.

Definition

ChEBI: 2-amino-3-phosphonopropanoic acid is a non-proteinogenc alpha-amino acid that is alanine in which one of the hydrogens of the terminal methyl group has been replaced by a dihydroxy(oxido)-lambda(5)-phosphanyl group. It has a role as a metabotropic glutamate receptor antagonist and a human metabolite. It is a non-proteinogenic alpha-amino acid, a member of phosphonic acids and an alanine derivative.

(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST Preparation Products And Raw materials

Raw materials

Preparation Products

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(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST Suppliers

China 15 India 1 Switzerland 1 United States 2 Global 19

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5652-28-8, (+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONISTRelated Search:

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(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST

2-Amino-3-phosphonopropionic acid

2-AP3

Alanine, 3-phosphono-

5652-28-8