ChemicalBook > CAS DataBase List > JNJ 16259685

JNJ 16259685

Product Name
JNJ 16259685
CAS No.
409345-29-5
Chemical Name
JNJ 16259685
Synonyms
CS-2455;JNJ16259865;JNJ 16259685;.TN.T 16259685;CAS:409345-29-5;JNJ-16259685 (JNJ16259685);JNJ16259685, 10 mM in DMSO;3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl-(4-methoxycyclohexyl)methanone;7-[(1s,4s)-4-methoxycyclohexanecarbonyl]-2H,3H,4H-pyrano[2,3-b]quinoline;(3,4-DIHYDRO-2H-PYRANO[2,3-B]QUINOLIN-7-YL)-(CIS-4-METHOXYCYCLOHEXYL)-METHANONE
CBNumber
CB5845428
Molecular Formula
C20H23NO3
Formula Weight
325.4
MOL File
409345-29-5.mol
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JNJ 16259685 Property

Melting point:
102-104°C
Boiling point:
502.5±50.0 °C(Predicted)
Density 
1.21±0.1 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
Chloroform (Slightly), DMSO (Slightly)
pka
2.60±0.20(Predicted)
form 
White to off-white solid.
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
2333
Product name
JNJ16259685
Purity
≥98%(HPLC)
Packaging
10
Price
$259
Updated
2021/12/16
Tocris
Product number
2333
Product name
JNJ16259685
Purity
≥98%(HPLC)
Packaging
50
Price
$1082
Updated
2021/12/16
TRC
Product number
J211305
Product name
JNJ16259685
Packaging
100mg
Price
$925
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611640
Product name
JNJ-16259685
Packaging
1g
Price
$1802
Updated
2021/12/16
ChemScene
Product number
CS-5874
Product name
JNJ16259685
Purity
98.85%
Packaging
5mg
Price
$108
Updated
2021/12/16
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JNJ 16259685 Chemical Properties,Usage,Production

Uses

JNJ 16259685 is a metabotropic glutamate receptor-1 antagonist that alters select behavior in mouse model of fragile X syndrome.

Definition

ChEBI: 3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl-(4-methoxycyclohexyl)methanone is an organonitrogen heterocyclic compound, an oxacycle and an organic heterotricyclic compound.

in vivo

JNJ16259685 (0.125, 0.25, 0.5, 1, 2, 4 and 8 mg/kg, i.p) significantly reduces the time spent in digging behaviours (0.25-8 mg/kg), threat (all doses) and attack, in comparison with vehicle group[1]. JNJ16259685 (30 mg/kg) produces very minimal effects on locomotor activity. JNJ16259685 dramatically reduces rearing behavior, exploration of a novel environment and lever pressing for a food reward (rat: 0.3 mg/kg; mouse: 1 mg/kg). Subcutaneously administered JNJ16259685 (30 mg/kg) has no effect on reflexive startle responses to loud auditory stimuli or foot shock in mice[2]. JNJ16259685 exhibits high potencies in occupying central mGlu1 receptors in the rat cerebellum and thalamus (ED50=0.040 and 0.014 mg/kg, respectively)[3].

IC 50

mGluR1: 19 nM (IC50)

storage

+4°C

JNJ 16259685 Preparation Products And Raw materials

Raw materials

Preparation Products

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JNJ 16259685 Suppliers

China 64 Germany 1 Switzerland 1 United Kingdom 1 United States 10 USA 1 Global 78
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409345-29-5, JNJ 16259685Related Search:

4-Phosphonophenylglycine AIDA L-AP4 IBOTENIC ACID L-AP3 (+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST QUISQUALIC ACID (+/-)-ALPHA-METHYL-(4-SULFONOPHENYL)GLYCINE (2S,3S,4S)-2-METHYL-2-(CARBOXYCYCLOPROPYL)GLYCINE (S)-MPPG CPPG (2R,4R)-APDC MPPG 3-ETHYL-2-HYDROXYQUINOLINE 6-ISOBUTYLQUINOLINE 6-METHYLQUINOLIN-2(1H)-ONE 6-ACETYLQUINOLINE JNJ 16259685

  • (3,4-DIHYDRO-2H-PYRANO[2,3-B]QUINOLIN-7-YL)-(CIS-4-METHOXYCYCLOHEXYL)-METHANONE
  • JNJ 16259685
  • JNJ16259865
  • CS-2455
  • 3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl-(4-methoxycyclohexyl)methanone
  • .TN.T 16259685
  • inhibit,Inhibitor,mGluR,JNJ16259685,JNJ 16259685,JNJ-16259685,Metabotropic glutamate receptors
  • Methanone, (3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)(cis-4-methoxycyclohexyl)-
  • 7-[(1s,4s)-4-methoxycyclohexanecarbonyl]-2H,3H,4H-pyrano[2,3-b]quinoline
  • JNJ16259685, 10 mM in DMSO
  • JNJ-16259685 (JNJ16259685)
  • CAS:409345-29-5
  • 409345-29-5
  • Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals