BIA 2-093
- Product Name
- BIA 2-093
- CAS No.
- 236395-14-5
- Chemical Name
- BIA 2-093
- Synonyms
- Aptiom;Exalief;Stedesa;Zebinix;Sep 0002093;BIA 2-093;APTIOM;Eslikazepine Acetate;S-Licarbazepine Acetate;EslicarbazepineAcetate>Licarbazepine Acetate S-Isomer
- CBNumber
- CB5503197
- Molecular Formula
- C17H16N2O3
- Formula Weight
- 296.32
- MOL File
- 236395-14-5.mol
BIA 2-093 Property
- Melting point:
- 183-185°C
- Boiling point:
- 427.4±55.0 °C(Predicted)
- Density
- 1.32
- storage temp.
- Sealed in dry,2-8°C
- solubility
- H2O: insoluble
- form
- solid
- pka
- 13.97±0.40(Predicted)
- color
- white
- InChIKey
- QIALRBLEEWJACW-INIZCTEOSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B5435
- Product name
- BIA 2-093
- Purity
- ≥98% (HPLC), solid
- Packaging
- 10mg
- Price
- $216
- Updated
- 2024/03/01
- Product number
- E1046
- Product name
- Eslicarbazepine Acetate
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 200mg
- Price
- $194
- Updated
- 2024/03/01
- Product number
- E1046
- Product name
- Eslicarbazepine Acetate
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 1g
- Price
- $677
- Updated
- 2024/03/01
- Product number
- 23656
- Product name
- Eslicarbazepine Acetate
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 23656
- Product name
- Eslicarbazepine Acetate
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $176
- Updated
- 2024/03/01
BIA 2-093 Chemical Properties,Usage,Production
Description
Although epilepsy is a neurological disorder with varying etiology and severity, the common feature is unprovoked, recurring seizures. Even when traditional AEDs, such as phenobarbital, phenytoin, carbamazepine, and valproate, control seizure activity, their effectiveness is hampered by considerable side effects and the tendency for drug-drug interactions. Designed for improved efficacy and safety, eslicarbazepine acetate is a third-generation AED that has been approved as adjunctive therapy for partial-onset seizures with or without secondary generalization. As a member of the carbamazepine family (first generation), it is the prodrug of eslicarbazepine and the active metabolite of oxcarbazepine (second generation). .
Description
Eslicarbazepine acetate is a sodium channel blocker (IC50 = 138 nM in a radioligand binding assay). It inhibits sodium uptake in a dose-dependent manner in rat cortical synaptosomes at concentrations ranging from 30-300 μM. In vivo, oral and i.p. administration of eslicarbazepine acetate is protective against seizures induced by maximal electroshock (MES) in mice with ED50 values of 4.7 and 6.3 mg/kg, respectively, which are well below the median toxic dose (TD50) values of 358.7 and 78.6 mg/kg for oral and i.p. administration respectively. High-dose administration (30 mg/kg) of eslicarbazepine acetate prevents picrotoxin-induced seizures in rats. Low-dose administration (10 mg/kg) does not suppress picrotoxin-induced seizures, however, it reduces seizure number and duration. Formulations containing eslicarbazepine acetate have been used for the treatment of partial-onset seizures.
Chemical Properties
White to Off-White Solid
Originator
BIAL Group (Spain)
Uses
Eslicarbazepine acetate, (BIA 2-093), is a promising antiepileptic drug structurally related to Carbamazepine and Oxcarbazepine. Neuroprotective & Neuroresearch product.
Definition
ChEBI: The acetate ester, with S configuration, of licarbazepine. An anticonvulsant, it is approved for use in Europe and the United States as an adjunctive therapy for epilepsy.
brand name
Zebinix; Exalief, Stedesa
Side effects
The most common adverse events occurring with an incidence of >2% were dizziness, somnolence, nausea, diplopia, headache, vomiting, abnormal coordination, blurred vision, vertigo, and fatigue. While most of these side effects appeared to be mild to moderate, they did display a dose dependency. Although eslicarbazepine acetate is only contraindicated in patients with a known hypersensitivity to the carbamazepine family of AEDs, caution should be exercised in patients with cardiac conduction abnormalities (potential for prolongations in PR intervals), renal impairment, and in patients of Han Chinese and Thai origin since the presence of HLA-B*1502 allele in these individuals has been shown to be strongly associated with the risk of developing Stevens-Johnson syndrome. Regarding drug interactions, eslicarbazepine acetate may decrease the effectiveness of hormonal contraceptives, so alternative or additional methods of contraception should be considered.
BIA 2-093 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BIA 2-093 manufacturers
- Product
- Blonanserin 236395-14-5
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 9%
- Supply Ability
- 100kg
- Release date
- 2018-12-23