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ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE

Product Name
ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE
CAS No.
71774-13-5
Chemical Name
ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE
Synonyms
cAMPS-Sp;(S)-Adenosine;Sp cAMPS,SpcAMPS;Rp cAMPS TEA salt;Rp-cAMPS TEA salt;Triethylammoniumsalt;camps,sp-isomer,teasalt;ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE;Adenosine, cyclic 3',5'-[hydrogen (S)-phosphorothioate];Adenosine-3'',5''-cyclic monophosphothioate sodium salt Sp isomer
CBNumber
CB5506390
Molecular Formula
C10H12N5O5PS
Formula Weight
345.27
MOL File
71774-13-5.mol
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ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE Property

Boiling point:
648.0±65.0 °C(predicted)
Density 
2.38±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
storage temp. 
Desiccate at -20°C
pka
-0.55±0.60(predicted)
form 
crystalline solid
Water Solubility 
water: 20mg/mL
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
A280468
Product name
(S)-Adenosine,cyclic3'',5''-(hydrogenphosphorothioate)triethylammonium
Packaging
2.5mg
Price
$240
Updated
2021/12/16
TRC
Product number
A280468
Product name
(S)-Adenosine,cyclic3'',5''-(hydrogenphosphorothioate)triethylammonium
Packaging
1mg
Price
$120
Updated
2021/12/16
Biosynth Carbosynth
Product number
NA08994
Product name
Adenosine 3',5'-cyclic monophosphothioate Sp-isomer sodium salt
Packaging
1mg
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
NA08994
Product name
Adenosine 3',5'-cyclic monophosphothioate Sp-isomer sodium salt
Packaging
2mg
Price
$250
Updated
2021/12/16
Biosynth Carbosynth
Product number
NA08994
Product name
Adenosine 3',5'-cyclic monophosphothioate Sp-isomer sodium salt
Packaging
5mg
Price
$450
Updated
2021/12/16
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ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE Chemical Properties,Usage,Production

Uses

(S)-Adenosine, cyclic 3'',5''-(hydrogenphosphorothioate) triethylammonium is an activator of PKA.

Definition

ChEBI: (Sp)-cAMPS is a nucleoside 3',5'-cyclic phosphorothioate having adenine as the nucleobase (the Sp-stereoisomer). It has a role as a protein kinase agonist. It is a member of purines and a nucleoside 3',5'-cyclic phosphorothioate. It is functionally related to a 3',5'-cyclic AMP.

Biological Activity

Cell-permeable cAMP analog that activates cAMP receptor proteins such as PKA and cAMP-regulated guanine nucleotide exchange factor.

in vivo

In chronic alcohol consumption (CAC) mice, direct infusion of the Sp-cAMPS (1 μg/μL) into the prefrontal cortex significantly improves or impairs, respectively, working memory performance in withdrawn and water animals[5].

IC 50

PKA I; PKA II; PDE3A: 47.6 μM (Ki); PDE10 GAF domain: 50 μM (EC50)

ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE Suppliers

China 9 Germany 2 United Kingdom 3 United States 8 Global 22
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
BIOTREND Chemicals AG
Tel
--
Fax
--
Email
info@biotrend.ch
Country
Germany
ProdList
1250
Advantage
62

71774-13-5, ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATERelated Search:

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  • adenosine-3’,5’-cyclicmonophosphorothioate,sp-isomer(sp-camps),sodiumsalt
  • camps,sp-isomer,teasalt
  • ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE
  • (S)-Adenosine
  • cAMPS-Sp
  • Triethylammoniumsalt
  • (S)-ADENOSINE, CYCLIC 3',5'-(HYDROGENPHOSPHOROTHIOATE) TRIETHYLAMMONIUM
  • ADENOSINE3,5-CYCLICMONOPHOSPHOTHIOATESP-ISOMERTRIETHYLAMMONIUMSALT,HIGHPURITY
  • Adenosine-3'',5''-cyclic monophosphothioate sodium salt Sp isomer
  • Adenosine, cyclic 3',5'-[hydrogen (S)-phosphorothioate]
  • Rp cAMPS TEA salt
  • Rp-cAMPS TEA salt
  • Sp cAMPS,SpcAMPS
  • 71774-13-5
  • C10H12N5O5PSC6H16N
  • Cyclic Nucleotide related