2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS
- Product Name
- 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS
- CAS No.
- 33400-49-6
- Chemical Name
- 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS
- Synonyms
- 2-Amino-6-(4-fL;N2-(4-Fluorobenzyl);Flupirtine impurity B;amino)-3-nitropyridine;Flupirtine Impurity 14;-5-nitropyridine-2,6-diamine;FlupirtinemaleateintermediateⅡ;2-Amino-3-nitro-6-(4-fluorobenzylamino)pyridine;N2-(4-fluorobenzyl)-5-nitropyridine-2,6-diaMine;2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE
- CBNumber
- CB5511868
- Molecular Formula
- C12H11FN4O2
- Formula Weight
- 262.24
- MOL File
- 33400-49-6.mol
2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS Property
- Melting point:
- 178-180°C
- Boiling point:
- 464.5±45.0 °C(Predicted)
- Density
- 1.447±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 1.52±0.50(Predicted)
- color
- Yellow
- InChIKey
- ZVCIIRBNNSUNCH-UHFFFAOYSA-N
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- VBP00105
- Product name
- 2-Amino-3-nitro-6-(4-fluorobenzylamino)pyridine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $185
- Updated
- 2025/07/31
- Product number
- A618470
- Product name
- 2-Amino-6-[(4-fluorobenzyl)-amino]-3-nitropyridine
- Packaging
- 500mg
- Price
- $660
- Updated
- 2021/12/16
- Product number
- FA17653
- Product name
- 2-Amino-6-[(4-fluorobenzyl)-amino]-3-nitropyridine
- Packaging
- 1g
- Price
- $672.7
- Updated
- 2021/12/16
- Product number
- FA17653
- Product name
- 2-Amino-6-[(4-fluorobenzyl)-amino]-3-nitropyridine
- Packaging
- 2g
- Price
- $1223.1
- Updated
- 2021/12/16
- Product number
- 19813
- Product name
- 2-Amino-6-[(4-fluorobenzyl)-amino]-3-nitropyridine
- Packaging
- 2.5g
- Price
- $2620
- Updated
- 2021/12/16
2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS Chemical Properties,Usage,Production
Chemical Properties
Yellow Solid
Uses
Intermediate in the preparation of Flupirtine metabolites.
Synthesis
27048-04-0
140-75-0
33400-49-6
To a reaction flask was added 200 mL of methanol, 52.08 g of 2-amino-3-nitro-6-chloropyridine (compound 1), 37.54 g of p-fluorobenzylamine and 50.0 mL of triethylamine. The reaction mixture was heated to 80 °C and kept for 10 hours. After completion of the reaction, 10 times the volume of water was added to the reaction solution and a solid was precipitated, which was filtered and dried to give 76.47 g of 2-amino-3-nitro-6-(4-fluorobenzylamino)pyridine (Compound 3) in 97.2% yield and 99.62% purity (as determined by HPLC).
References
[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 23, p. 9739 - 9756
[2] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2012, vol. 67, # 12, p. 1297 - 1304
[3] Patent: CN105541705, 2016, A. Location in patent: Paragraph 0013; 0027; 0028
[4] Patent: WO2012/4391, 2012, A1. Location in patent: Page/Page column 39
[5] Patent: CN104086481, 2016, B. Location in patent: Paragraph 0033 - 0037
2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS manufacturers
- Product
- 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS 33400-49-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-09
- Product
- 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS 33400-49-6
- Price
- US $15.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2018-07-31