2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS

Product Name: 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS
CAS No.: 33400-49-6
Chemical Name: 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS
Synonyms: 2-Amino-6-(4-fL;N2-(4-Fluorobenzyl);Flupirtine impurity B;amino)-3-nitropyridine;Flupirtine Impurity 14;-5-nitropyridine-2,6-diamine;FlupirtinemaleateintermediateⅡ;2-Amino-3-nitro-6-(4-fluorobenzylamino)pyridine;N2-(4-fluorobenzyl)-5-nitropyridine-2,6-diaMine;2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE
CBNumber: CB5511868
Molecular Formula: C12H11FN4O2
Formula Weight: 262.24
MOL File: 33400-49-6.mol

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2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS Property

Melting point:: 178-180°C
Boiling point:: 464.5±45.0 °C(Predicted)
Density: 1.447±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 1.52±0.50(Predicted)
color: Yellow
InChIKey: ZVCIIRBNNSUNCH-UHFFFAOYSA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: VBP00105
Product name: 2-Amino-3-nitro-6-(4-fluorobenzylamino)pyridine
Purity: Aldrich
Packaging: 1g
Price: $185
Updated: 2025/07/31

TRC

Product number: A618470
Product name: 2-Amino-6-[(4-fluorobenzyl)-amino]-3-nitropyridine
Packaging: 500mg
Price: $660
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17653
Product name: 2-Amino-6-[(4-fluorobenzyl)-amino]-3-nitropyridine
Packaging: 1g
Price: $672.7
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17653
Product name: 2-Amino-6-[(4-fluorobenzyl)-amino]-3-nitropyridine
Packaging: 2g
Price: $1223.1
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 19813
Product name: 2-Amino-6-[(4-fluorobenzyl)-amino]-3-nitropyridine
Packaging: 2.5g
Price: $2620
Updated: 2021/12/16

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2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

Intermediate in the preparation of Flupirtine metabolites.

Synthesis

27048-04-0

140-75-0

33400-49-6

To a reaction flask was added 200 mL of methanol, 52.08 g of 2-amino-3-nitro-6-chloropyridine (compound 1), 37.54 g of p-fluorobenzylamine and 50.0 mL of triethylamine. The reaction mixture was heated to 80 °C and kept for 10 hours. After completion of the reaction, 10 times the volume of water was added to the reaction solution and a solid was precipitated, which was filtered and dried to give 76.47 g of 2-amino-3-nitro-6-(4-fluorobenzylamino)pyridine (Compound 3) in 97.2% yield and 99.62% purity (as determined by HPLC).

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 23, p. 9739 - 9756
[2] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2012, vol. 67, # 12, p. 1297 - 1304
[3] Patent: CN105541705, 2016, A. Location in patent: Paragraph 0013; 0027; 0028
[4] Patent: WO2012/4391, 2012, A1. Location in patent: Page/Page column 39
[5] Patent: CN104086481, 2016, B. Location in patent: Paragraph 0033 - 0037

2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS Suppliers

Canada 1 China 125 Germany 1 India 7 South Korea 1 United Kingdom 2 United States 9 Global 146

WeylChem GmbH

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Country: Germany
ProdList: 396
Advantage: 64

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View Lastest Price from 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS manufacturers

Dideu Industries Group Limited

Product: 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS 33400-49-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-09

Career Henan Chemical Co

Product: 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS 33400-49-6
Price: US $15.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2018-07-31

33400-49-6, 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALSRelated Search:

Flupirtine maleate TERT-BUTYL CARBAZATE CHEMBRDG-BB 4021959 2,6-DIAMINO-3-NITROSOPYRIDINE 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS

2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE

6-n-[(4-fluorophenyl)Methyl]-3-nitropyridine-2,6-diaMine

2,6-PyridinediaMine,N6-[(4-fluorophenyl)Methyl]-3-nitro-

N6-[(4-fluorophenyl)methyl]-3-nitropyridine-2,6-diamine

2-Amino-6-[(4-fluorobenzyl)-amino]-3-nitropyridine

6-[[(4-Fluorophenyl)methyl]amino]-3-nitro-2-pyridinamine

2-Amino-3-nitro-6-(4-fluorobenzylamino)pyridine

-5-nitropyridine-2,6-diamine

N2-(4-Fluorobenzyl)

2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS

N2-(4-fluorobenzyl)-5-nitropyridine-2,6-diaMine

N6-[(4-Fluorophenyl)Methyl]-3-nitro-2,6-pyridinediaMine

Flupirtine impurity B

FlupirtinemaleateintermediateⅡ

2-Amino-6-(4-fL

amino)-3-nitropyridine

2,6-PYRIDINEDIAMINE,N6-[(4-FLUOROPHENYL)METHYL]-3-NITRO- (CAS NO.33400-49-6)

2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS ISO 9001：2015 REACH

Flupirtine Impurity 14

33400-49-6

Amines

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals