ChemicalBook > CAS DataBase List > 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS

2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS

Product Name
2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS
CAS No.
33400-49-6
Chemical Name
2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS
Synonyms
2-Amino-6-(4-fL;N2-(4-Fluorobenzyl);Flupirtine impurity B;amino)-3-nitropyridine;Flupirtine Impurity 14;-5-nitropyridine-2,6-diamine;FlupirtinemaleateintermediateⅡ;2-Amino-3-nitro-6-(4-fluorobenzylamino)pyridine;N2-(4-fluorobenzyl)-5-nitropyridine-2,6-diaMine;2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE
CBNumber
CB5511868
Molecular Formula
C12H11FN4O2
Formula Weight
262.24
MOL File
33400-49-6.mol
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2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS Property

Melting point:
178-180°C
Boiling point:
464.5±45.0 °C(Predicted)
Density 
1.447±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
1.52±0.50(Predicted)
color 
Yellow
InChIKey
ZVCIIRBNNSUNCH-UHFFFAOYSA-N
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
VBP00105
Product name
2-Amino-3-nitro-6-(4-fluorobenzylamino)pyridine
Purity
Aldrich
Packaging
1g
Price
$185
Updated
2025/07/31
TRC
Product number
A618470
Product name
2-Amino-6-[(4-fluorobenzyl)-amino]-3-nitropyridine
Packaging
500mg
Price
$660
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA17653
Product name
2-Amino-6-[(4-fluorobenzyl)-amino]-3-nitropyridine
Packaging
1g
Price
$672.7
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA17653
Product name
2-Amino-6-[(4-fluorobenzyl)-amino]-3-nitropyridine
Packaging
2g
Price
$1223.1
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
19813
Product name
2-Amino-6-[(4-fluorobenzyl)-amino]-3-nitropyridine
Packaging
2.5g
Price
$2620
Updated
2021/12/16
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2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

Intermediate in the preparation of Flupirtine metabolites.

Synthesis

27048-04-0

140-75-0

33400-49-6

To a reaction flask was added 200 mL of methanol, 52.08 g of 2-amino-3-nitro-6-chloropyridine (compound 1), 37.54 g of p-fluorobenzylamine and 50.0 mL of triethylamine. The reaction mixture was heated to 80 °C and kept for 10 hours. After completion of the reaction, 10 times the volume of water was added to the reaction solution and a solid was precipitated, which was filtered and dried to give 76.47 g of 2-amino-3-nitro-6-(4-fluorobenzylamino)pyridine (Compound 3) in 97.2% yield and 99.62% purity (as determined by HPLC).

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 23, p. 9739 - 9756
[2] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2012, vol. 67, # 12, p. 1297 - 1304
[3] Patent: CN105541705, 2016, A. Location in patent: Paragraph 0013; 0027; 0028
[4] Patent: WO2012/4391, 2012, A1. Location in patent: Page/Page column 39
[5] Patent: CN104086481, 2016, B. Location in patent: Paragraph 0033 - 0037

2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS Suppliers

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View Lastest Price from 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS manufacturers

Dideu Industries Group Limited
Product
2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS 33400-49-6
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-09
Career Henan Chemical Co
Product
2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS 33400-49-6
Price
US $15.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2018-07-31

33400-49-6, 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALSRelated Search:

Flupirtine maleate TERT-BUTYL CARBAZATE CHEMBRDG-BB 4021959 2,6-DIAMINO-3-NITROSOPYRIDINE 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS

  • 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE
  • 6-n-[(4-fluorophenyl)Methyl]-3-nitropyridine-2,6-diaMine
  • 2,6-PyridinediaMine,N6-[(4-fluorophenyl)Methyl]-3-nitro-
  • N6-[(4-fluorophenyl)methyl]-3-nitropyridine-2,6-diamine
  • 2-Amino-6-[(4-fluorobenzyl)-amino]-3-nitropyridine
  • 6-[[(4-Fluorophenyl)methyl]amino]-3-nitro-2-pyridinamine
  • 2-Amino-3-nitro-6-(4-fluorobenzylamino)pyridine
  • -5-nitropyridine-2,6-diamine
  • N2-(4-Fluorobenzyl)
  • 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS
  • N2-(4-fluorobenzyl)-5-nitropyridine-2,6-diaMine
  • N6-[(4-Fluorophenyl)Methyl]-3-nitro-2,6-pyridinediaMine
  • Flupirtine impurity B
  • FlupirtinemaleateintermediateⅡ
  • 2-Amino-6-(4-fL
  • amino)-3-nitropyridine
  • 2,6-PYRIDINEDIAMINE,N6-[(4-FLUOROPHENYL)METHYL]-3-NITRO- (CAS NO.33400-49-6)
  • 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS ISO 9001：2015 REACH
  • Flupirtine Impurity 14
  • 33400-49-6
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals