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SRS16-86

Product Name
SRS16-86
CAS No.
1793052-96-6
Chemical Name
SRS16-86
Synonyms
SRS16-86;SRS16-86, 10 mM in DMSO;(Z)-tert-Butyl 4-(adamantan-1-ylamino)-3-((pyrimidin-5-ylmethylene)amino)benzoate;Benzoic acid, 3-[(Z)-(5-pyrimidinylmethylene)amino]-4-(tricyclo[3.3.1.13,7]dec-1-ylamino)-, 1,1-dimethylethyl ester;IRI,SRS16-86,Inhibitor,ferrostatin,SRS-16-86,ischemia-reperfusion injury,SCI,spinal cord injury,Ferroptosis,SRS1686,inhibit,SRS16 86
CBNumber
CB55540799
Molecular Formula
C26H32N4O2
Formula Weight
432.56
MOL File
1793052-96-6.mol
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SRS16-86 Property

Boiling point:
614.9±55.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (>25 mg/ml)
form 
solid
pka
5.58±0.20(Predicted)
color 
Yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26752
Product name
SRS16-86
Packaging
1mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
26752
Product name
SRS16-86
Packaging
5mg
Price
$359
Updated
2024/03/01
Cayman Chemical
Product number
26752
Product name
SRS16-86
Packaging
500μg
Price
$62
Updated
2024/03/01
Ambeed
Product number
A1490492
Product name
(Z)-tert-Butyl4-(adamantan-1-ylamino)-3-((pyrimidin-5-ylmethylene)amino)benzoate
Purity
98+%
Packaging
250mg
Price
$422
Updated
2021/12/16
Ambeed
Product number
A1490492
Product name
(Z)-tert-Butyl4-(adamantan-1-ylamino)-3-((pyrimidin-5-ylmethylene)amino)benzoate
Purity
98+%
Packaging
25mg
Price
$118
Updated
2021/12/16
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SRS16-86 Chemical Properties,Usage,Production

Description

SRS16-86 (1793052-96-6) is a third generation ferrostatin derivative with greater metabolic and plasma stability for in vivo studies. It protected mice in a renal severe ischemia-reperfusion injury model via inhibition of ferroptosis.1 SRS16-86 enhanced functional recovery after spinal cord injury in a rat model via upregulation of GPX4, GSH, and xCT as well as downregulation of lipid peroxidation marker 4-hydroxynonenal.2

Uses

SRS16-86 is a potent inhibitor of ferroptosis[1]. SRS16-86 is more stable than more stable to metabolism and plasma than Ferrostatin-1 in vivo. SRS16-86 can be used for renal ischemia-reperfusion injury (IRI) and spinal cord injury (SCI) research[2][3].

Definition

ChEBI: SRS16-86 is an ethyl ester resulting from the formal condensation of the carboxy group of 4-[(adamantan-1-yl)amino]-3-{(Z)-[(pyrimidin-5-yl)methylidene]amino}benzoic acid with tert-butanol. It is an inhibitor of ferroptosis induced by erastin in HT-1080 and NIH3T3 cells when used at a concentration of 1 muM. It has a role as a ferroptosis inhibitor. It is a tert-butyl ester, a member of adamantanes, a member of pyrimidines, a substituted aniline, a secondary amino compound and an imine.

in vivo

SRS16-86 (intraperitoneal injection; 2 mg/kg; 15 min before the onset of surgery) protects mice from functional acute renal failure and structural organ damage after ischemia–reperfusion injury (IRI)[2].SRS16-86 (intraperitoneal injection; 2 mg/kg; 4 weeks) combination therapy with [Nec-1+SfA] is superior in the prevention of renal IRI compared with the double-combination therapy with [Nec-1+SfA].Addition of 16-86 reduces plasma levels of serum urea and serum creatinine in IRI mice model[2].SRS16-86 (intraperitoneal injection; 15 mg/kg; once a day; 7 days) enhances functional recovery after SCI, it decreases the levels of proinflammatory cytokines and the inflammatory adhesion factor in injured spinal cord in rats[3].

Animal Model:Renal IRI model
Dosage:2 mg/kg; 15 min before the onset of surgery
Administration:Intraperitoneal injection; 2 mg/kg; 15 min before the onset of surgery
Result:Was protective from renal IRI.
Animal Model:Renal IRI model
Dosage:2 mg/kg
Administration:Combination with Necrostatin-1/Sanglifehrin A; 2 mg/kg; 4 weeks
Result:Further increased the protective effect of [Necrostatin-1/Sanglifehrin A] combination therapy in renal IRI model.

References

[1] ANDREAS LINKERMANN. Synchronized renal tubular cell death involves ferroptosis.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 47: 16836-16841. DOI:10.1073/pnas.1415518111
[2] YAN ZHANG . Ferroptosis inhibitor SRS 16-86 attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury[J]. Brain Research, 2019, 1706: Pages 48-57. DOI:10.1016/j.brainres.2018.10.023

SRS16-86 Preparation Products And Raw materials

Raw materials

Preparation Products

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SRS16-86 Suppliers

China 30 United States 4 Global 34
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
ProdList
9803
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Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
ProdList
86249
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Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
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China
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9695
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ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
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2853530910@QQ.com
Country
China
ProdList
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Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
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QQ 3610331285
Email
sales@chemegen.com
Country
China
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11218
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Jinan Jiuli Biotechnology Co. , Ltd.
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15865264761
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486064515@qq.com
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China
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4887
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Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
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China
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59936
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TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
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China
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24960
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Shanghai Jieshikai Biotechnology Co. , Ltd.
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021-57520305 13795461237
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zhuruyan@jskchem.com
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China
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49234
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1793052-96-6, SRS16-86Related Search:

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide ML335 AZ20 Pomalidomide

  • SRS16-86
  • Benzoic acid, 3-[(Z)-(5-pyrimidinylmethylene)amino]-4-(tricyclo[3.3.1.13,7]dec-1-ylamino)-, 1,1-dimethylethyl ester
  • (Z)-tert-Butyl 4-(adamantan-1-ylamino)-3-((pyrimidin-5-ylmethylene)amino)benzoate
  • IRI,SRS16-86,Inhibitor,ferrostatin,SRS-16-86,ischemia-reperfusion injury,SCI,spinal cord injury,Ferroptosis,SRS1686,inhibit,SRS16 86
  • SRS16-86, 10 mM in DMSO
  • 1793052-96-6