SRS16-86
- Product Name
- SRS16-86
- CAS No.
- 1793052-96-6
- Chemical Name
- SRS16-86
- Synonyms
- SRS16-86;SRS16-86, 10 mM in DMSO;(Z)-tert-Butyl 4-(adamantan-1-ylamino)-3-((pyrimidin-5-ylmethylene)amino)benzoate;Benzoic acid, 3-[(Z)-(5-pyrimidinylmethylene)amino]-4-(tricyclo[3.3.1.13,7]dec-1-ylamino)-, 1,1-dimethylethyl ester;IRI,SRS16-86,Inhibitor,ferrostatin,SRS-16-86,ischemia-reperfusion injury,SCI,spinal cord injury,Ferroptosis,SRS1686,inhibit,SRS16 86
- CBNumber
- CB55540799
- Molecular Formula
- C26H32N4O2
- Formula Weight
- 432.56
- MOL File
- 1793052-96-6.mol
SRS16-86 Property
- Boiling point:
- 614.9±55.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (>25 mg/ml)
- form
- solid
- pka
- 5.58±0.20(Predicted)
- color
- Yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
N-Bromosuccinimide Price
- Product number
- 26752
- Product name
- SRS16-86
- Packaging
- 1mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 26752
- Product name
- SRS16-86
- Packaging
- 5mg
- Price
- $359
- Updated
- 2024/03/01
- Product number
- 26752
- Product name
- SRS16-86
- Packaging
- 500μg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- A1490492
- Product name
- (Z)-tert-Butyl4-(adamantan-1-ylamino)-3-((pyrimidin-5-ylmethylene)amino)benzoate
- Purity
- 98+%
- Packaging
- 25mg
- Price
- $118
- Updated
- 2021/12/16
- Product number
- A1490492
- Product name
- (Z)-tert-Butyl4-(adamantan-1-ylamino)-3-((pyrimidin-5-ylmethylene)amino)benzoate
- Purity
- 98+%
- Packaging
- 50mg
- Price
- $177
- Updated
- 2021/12/16
SRS16-86 Chemical Properties,Usage,Production
Description
SRS16-86 (1793052-96-6) is a third generation ferrostatin derivative with greater metabolic and plasma stability for in vivo studies. It protected mice in a renal severe ischemia-reperfusion injury model via inhibition of ferroptosis.1 SRS16-86 enhanced functional recovery after spinal cord injury in a rat model via upregulation of GPX4, GSH, and xCT as well as downregulation of lipid peroxidation marker 4-hydroxynonenal.2
Uses
SRS16-86 is a potent inhibitor of ferroptosis[1]. SRS16-86 is more stable than more stable to metabolism and plasma than Ferrostatin-1 in vivo. SRS16-86 can be used for renal ischemia-reperfusion injury (IRI) and spinal cord injury (SCI) research[2][3].
Definition
ChEBI: SRS16-86 is an ethyl ester resulting from the formal condensation of the carboxy group of 4-[(adamantan-1-yl)amino]-3-{(Z)-[(pyrimidin-5-yl)methylidene]amino}benzoic acid with tert-butanol. It is an inhibitor of ferroptosis induced by erastin in HT-1080 and NIH3T3 cells when used at a concentration of 1 muM. It has a role as a ferroptosis inhibitor. It is a tert-butyl ester, a member of adamantanes, a member of pyrimidines, a substituted aniline, a secondary amino compound and an imine.
in vivo
SRS16-86 (intraperitoneal injection; 2 mg/kg; 15 min before the onset of surgery) protects mice from functional acute renal failure and structural organ damage after ischemia–reperfusion injury (IRI)[2].SRS16-86 (intraperitoneal injection; 2 mg/kg; 4 weeks) combination? therapy with [Nec-1+SfA] is superior in the prevention of renal IRI compared with the double-combination therapy with [Nec-1+SfA].?Addition of 16-86 reduces plasma levels of serum urea and serum creatinine in IRI mice model[2].SRS16-86 (intraperitoneal injection; 15 mg/kg; once a day; 7 days) enhances functional recovery after SCI, it decreases the levels of proinflammatory cytokines and the inflammatory adhesion factor in injured spinal cord in rats[3].
| Animal Model: | Renal IRI model |
| Dosage: | 2 mg/kg; 15 min before the onset of surgery |
| Administration: | Intraperitoneal injection; 2 mg/kg; 15 min before the onset of surgery |
| Result: | Was protective from renal IRI. |
| Animal Model: | Renal IRI model |
| Dosage: | 2 mg/kg |
| Administration: | Combination with Necrostatin-1/Sanglifehrin A; 2 mg/kg; 4 weeks |
| Result: | Further increased the protective effect of [Necrostatin-1/Sanglifehrin A] combination therapy in renal IRI model. |
References
[1] ANDREAS LINKERMANN. Synchronized renal tubular cell death involves ferroptosis.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 47: 16836-16841. DOI:10.1073/pnas.1415518111
[2] YAN ZHANG . Ferroptosis inhibitor SRS 16-86 attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury[J]. Brain Research, 2019, 1706: Pages 48-57. DOI:10.1016/j.brainres.2018.10.023
SRS16-86 Preparation Products And Raw materials
Raw materials
Preparation Products
SRS16-86 Suppliers
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 15076683720
- Fax
- 022-23754520
- klq@cw-bio.com
- Country
- China
- ProdList
- 9377
- Advantage
- 55
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8000
- Advantage
- 62
- Tel
- 400-9205774
- sales@glpbio.cn
- Country
- China
- ProdList
- 6777
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- 15865264761
- 486064515@qq.com
- Country
- China
- ProdList
- 4858
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 59936
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24964
- Advantage
- 58
- Tel
- 021-57520305 13795461237
- zhuruyan@jskchem.com
- Country
- China
- ProdList
- 49234
- Advantage
- 58