RBM10 antibody
Source Reactivity Background References- Product Name
- RBM10 antibody
- Chemical Name
- RBM10 antibody
- Synonyms
- RBM10 antibody
- CBNumber
- CB55690566
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb312883
- Product name
- RBM10 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb312883
- Product name
- RBM10 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
RBM10 antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Rat;Monkey
Background
RBM10 is an RNA binding protein and a paralog to tumor suppressor RBM5. Alternative splicing creates two highly expressed variants that differ by one exon. RBM10 controls alternative splicing and exon skipping of mRNAs, including Fas and Bcl-x. RBM10 has been shown to affect apoptosis via up regulation of TNF-α mRNA. In lung cancer, RBM10 mutations disrupt the splicing of NUMB, a regulator of Notch signaling. Fusion of the RBM10 gene with TFE3 has been found in renal cell carcinoma. Mutations of RBM10 causes TARP syndrome, an x-linked, lethal disorder characterized by various developmental defects.
References
[1] Timmer, T. et al. (1999) Genomics 60, 238-40.
[2] Bonnal, S. et al. (2008) Mol Cell 32, 81-95.
[3] Wang, Y. et al. (2013) EMBO Mol Med 5, 1431-42.
[4] Inoue, A. et al. (2014) FEBS Lett 588, 942-7.
[5] Wang, K. et al. (2012) J Cell Death 5, 1-19.
[6] Bechara, E.G. et al. (2013) Mol Cell 52, 720-733.
[7] Hernández, J. et al. (2016) RNA Biol 13, 466-472.
[8] Just, P.A. et al. (2016) Genes Chromosomes Cancer 55, 541-548.
[9] Argani, P. et al. (2017) Am J Surg Pathol 41, 655-662.
[10] Gorlin, R.J. et al. (1970) Am J Dis Child 119, 176-8.
RBM10 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
RBM10 antibody Suppliers
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