SGTA antibody
Source Applications Reactivity Immunogen Background References- Product Name
- SGTA antibody
- Chemical Name
- SGTA antibody
- Synonyms
- SGTA antibody
- CBNumber
- CB55695420
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb100055
- Product name
- SGTA antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb100055
- Product name
- SGTA antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
SGTA antibody Chemical Properties,Usage,Production
Source
Rabbit
Applications
The antibody has been tested by ELISA, Western blot analysis, Flow cytometry and ICC/IF to assure specificity and reactivity.
Reactivity
Human
Immunogen
Anti-human SGTA mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human SGTA protein 1-313 amino acids purified from E. coli.
Background
SGTA is a ubiquitously expressed protein that contains three TPR protein-protein interaction duplicates. SGTA takes part as a component of the androgen receptor (AR)-chaperone-cochaperone complex, functions as a cochaperone and participates in androgen signaling. SGTA binds directly to HSC70 and HSP70 and mediates their ATPase activity. SGTA gene encodes a protein that is able to interact with the chief nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate. In addition, SGTA interacts with Vpu and Gag from HIV-1, SARS-CoV accessory protein 7a, DNAJC5 and DNAJC5B. Since this transcript is expressed universally in several tissues, SGTA serves a housekeeping function. While being involved in apoptosis and androgen signaling, SGTA is a possible molecule for polycystic ovary syndrome, a disorder characterized by androgen excess, obesity and menstrual disturbances.
References
[1] Liu, F.H. et al. (1999) J Biol Chem 274, 34425-32.
[2] Tobaben, S. et al. (2003) J Biol Chem 278, 38376-83.
[3] Cziepluch, C. et al. (1998) J Virol 72, 4149-56.
[4] Scheufler, C. et al. (2000) Cell 101, 199-210.
[5] Liou, S.T. and Wang, C. (2005) Arch Biochem Biophys 435, 253-263.
[6] Yin, H. et al. (2006) Biochem Biophys Res Commun 343, 1153-8.
SGTA antibody Preparation Products And Raw materials
Raw materials
Preparation Products
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