Sennoside A

Product Name: Sennoside A
CAS No.: 81-27-6
Chemical Name: Sennoside A
Synonyms: Pursenni;SENNOSIDA;Glysennid;SENNOSIDE;PURSENNID;Nsc 112929;GLYSENNIDE;PURSENNIDE;SENNOSIDE A;Sennoside A1
CBNumber: CB5663235
Molecular Formula: C42H38O20
Formula Weight: 862.74
MOL File: 81-27-6.mol

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Sennoside A Property

Melting point:: >191oC (dec.)
alpha: D20 -164° (c = 0.1 in 60% acetone); D20 -147° (c = 0.1 in 70% acetone); D20 -24° (c = 0.2 in 70% dioxane)
Boiling point:: 1144.8±65.0 °C(Predicted)
Density: 1.743±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Aqueous Base (Slightly, Heated), DMSO (Slightly, Heated)
form: Solid
pka: 3.31±0.40(Predicted)
color: Yellow to Dark Yellow
BRN: 5723746
Stability:: Hygroscopic
InChIKey: IPQVTOJGNYVQEO-KGFNBKMBSA-N
LogP: 1.880 (est)

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Safety

Risk Statements: 22
Safety Statements: 22-45
WGK Germany: 3
F: 3-10
HS Code: 29173990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 68909
Product name: Sennoside A
Purity: analytical standard
Packaging: 5mg
Price: $103.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHL89276
Product name: Sennoside A
Purity: phyproof? Reference Substance
Packaging: 20MG
Price: $485
Updated: 2025/07/31

Sigma-Aldrich

Product number: 68909
Product name: Sennoside A
Purity: analytical standard
Packaging: 25mg
Price: $561
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1612018
Product name: Sennoside A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 20mg
Price: $576
Updated: 2025/07/31

Sigma-Aldrich

Product number: 01870575
Product name: Sennoside A
Purity: primary reference standard
Packaging: 25MG
Price: $606
Updated: 2023/06/20

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Sennoside A Chemical Properties,Usage,Production

Chemical Properties

Light yellow powder

Uses

a natural anthroquinonone glucoside calcium complex with laxative properties

Uses

Sennoside A is used as a laxative in the treatment of constipation. In addition. it is hypothesized to induce cell proliferation and may be a potential carcinogenic agent.

Definition

ChEBI: Sennoside A is a member of the class of sennosides that is rel-(9R,9'R)-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid which is substituted by hydroxy groups at positions 4 and 4', by beta-D-glucopyranosyloxy groups at positions 5 and 5', and by oxo groups at positions 10 and 10'. The exact stereochemisty at positions 9 and 9' is not known - it may be R,R (as shown) or S,S. It is a member of sennosides and an oxo dicarboxylic acid.

in vivo

Sennoside A (25 mg/kg, 50 mg/kg; intragastric gavage for 12 weeks) alters the gut microbiome composition of type 2 diabetes (T2D) mice and mediates anti-obesity effects^[3].
Sennoside A also reduces inflammation and increases tight junction proteins in the ileum of genetically defective mice^[3].

IC 50

HIV-1

Purification Methods

Sennoside A (bianthraquinonyl-bis-glucoside R,R-enantiomer) [81-27-6] M 862.7, m 220 -2 4 0o(dec), [ ] D -164o (c 0.1, Me2CO/H2O 6:4), [ ] D -24o (c 0.2, 70% aqueous dioxane). Sennoside A forms yellow crystals from aqueous acetone, 2-ethoxyethanol or large volumes of H2O. [Stoll et al. Helv Chim Acta 32 1896 1900, Beilstein 17 III/IV 3403.]

Sennoside A Preparation Products And Raw materials

Raw materials

Preparation Products

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Sennoside A Suppliers

China 313 France 2 Germany 4 India 5 Japan 2 Switzerland 1 United Kingdom 10 United States 32 USA 1 Global 370

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View Lastest Price from Sennoside A manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.

Product: Sennoside A; Senna leaf extract 81-27-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 95%-99% HPLC
Supply Ability: 1000KG
Release date: 2022-09-19

Wuhan Haorong Biotechnology Co.,Ltd

Product: Sennoside A 81-27-6
Price: US $0.00-0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 200000
Release date: 2023-08-15

BINBO BIOLOGICAL CO.,LTD

Product: Sennoside A 81-27-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 1000 kg
Release date: 2024-04-12

81-27-6, Sennoside ARelated Search:

Sennoside C,Sennoside C Sennoside D,Sennoside D Sennoside B SENNIDINE A 2,2'-DIHYDROXYBENZOPHENONE 4-FORMYL-3-HYDROXYBENZOIC ACID 4-Acetylbenzoic acid 5-ISOPROPYL-3-METHYLPHENOL 4-BROMOBENZHYDROL BIANTHRONYL 4-ETHYL-3-HYDROXYBENZOIC ACID 1,1,2,2-TETRAPHENYLETHANE SENNOSIDE,SENNOSIDE A AND B,SENNOSIDE A AND B,SENNOSIDE 3-Hydroxy-4-methylbenzoic acid HELICIN SENNOSIDES 3-HYDROXY-5-METHYL-BENZOIC ACID 3-ISOBUTYL-BENZOIC ACID

Sennoside A std.

SENNOSIDEA60%

SENNOSIDE A(P)

SENNOSIDE A(SH)

SENNOSIDA

CALCIUM SENNOSIDE 5%, 10%, 20%, 60%

[9,9'-Bianthracene]-2,2'-dicarboxylicacid,5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-,(9R,9'R)-

Sennoside A1

Einecs 201-339-9

Nsc 112929

SENNIDINE A(RG)

Sennoside A ,98%

Gentle Nature

Glysennid

Sennoside A (20 mg)

SENNOSIDE A hplc

SENNOSIDE A WITH HPLC

11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid,11,12-EET

Pursenni

Sennoside A (20 mg) ((9R,9'R)-5,5'-Bis(beta-d-glucopyranosyloxy)-4,4'-dihydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid)

Sennoside USP

GLYSENNIDE

SENNOSIDE

SENNOSIDE A

PURSENNID

PURSENNIDE

Tomato juice

4,4',10,10'-Tetrahydroxy-5,5'-bis(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-[9,9'-bianthracene]-2,2'-dicarboxylic acid

Sennoside A RS

4,4'-dihydroxy-10,10'-dioxo-5,5'-bis((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-9,9',10,10'-tetrahydro-[9,9'-bianthracene]-2,2'-dicarboxylic acid

81-27-6 Sennoside A

Sennoside A ((9R,9''R)-5,5''-Bis(beta-d-glucopyranosyloxy)-4,4''-dihydroxy-10,10''-dioxo-9,9'',10,10''-te (1612018)

(9R,9'R)-4,4'-Dihydroxy-10,10'-dioxo-5,5'-bis(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-9,9',10,10'-tetrahydro-[9,9'-bianthracene]-2,2'-dicarboxylic acid

Sennoside A (6CI, 7CI, 8CI)

Sennoside A(AS)

Sennoside A, 10 mM in DMSO

Senna Leaf P.E Sennosid

81-27-6

SA - SM

Analytical Standards

Alphabetic

Analytical Chromatography Product Catalog

The group of Sennosides

Anthraquinones, Hydroquinones and Quinones

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Inhibitors