ChemicalBook > CAS DataBase List > 4-Hydroxyindole

4-Hydroxyindole

Product Name
4-Hydroxyindole
CAS No.
2380-94-1
Chemical Name
4-Hydroxyindole
Synonyms
1H-INDOL-4-OL;4-Hdroxyindole;4-INDOLOL;INDOL-4-OL;1H-INDOLE-4-OL;4-HydroxyindoL;4-HYDROXYINDOLE;4-Hydroxxyindole;4-Hydroxylndole;4-Hydroxyindole>
CBNumber
CB5663260
Molecular Formula
C8H7NO
Formula Weight
133.15
MOL File
2380-94-1.mol
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4-Hydroxyindole Property

Melting point:
97-99 °C(lit.)
Boiling point:
245.66°C (rough estimate)
Density 
1.1475 (rough estimate)
vapor pressure 
0.019Pa at 25℃
refractive index 
1.5260 (estimate)
storage temp. 
0-6°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
9.89±0.40(Predicted)
color 
Dark Yellow to Green-Grey
Water Solubility 
slightly soluble
Sensitive 
Air Sensitive
BRN 
114905
InChIKey
NLMQHXUGJIAKTH-UHFFFAOYSA-N
LogP
1.57 at 25℃
CAS DataBase Reference
2380-94-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
IRRITANT, KEEP COLD
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
219878
Product name
4-Hydroxyindole
Purity
99%
Packaging
1g
Price
$62.9
Updated
2024/03/01
Sigma-Aldrich
Product number
1327157
Product name
4-Hydroxyindole
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25MG
Price
$1170
Updated
2024/03/01
TCI Chemical
Product number
H0582
Product name
4-Hydroxyindole
Purity
>99.0%(GC)
Packaging
5g
Price
$51
Updated
2021/12/16
TCI Chemical
Product number
H0582
Product name
4-Hydroxyindole
Purity
>99.0%(GC)
Packaging
25g
Price
$179
Updated
2021/12/16
Alfa Aesar
Product number
L14352
Product name
4-Hydroxyindole, 98%
Packaging
1g
Price
$18.65
Updated
2024/03/01
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4-Hydroxyindole Chemical Properties,Usage,Production

Chemical Properties

Off-White Cyrstalline Solid

Uses

4-Hydroxyindole is a Pindolol (P468000) impurity, which is a mixed adrenergic blocker and serotonin 5HT1A-receptor antagonist.

Definition

ChEBI: 4-hydroxyindole is a member of the class of hydroxyindoles that is 1H-indole substituted by a hydroxy group at position 4. It is a member of phenols and a member of hydroxyindoles.

Application

4-Hydroxyindole as simple indoles is the important raw material or intermediate in the synthesis of pharmaceutical products and industrial polymers. It effectively inhibits Abeta peptide-induced amyloid fibril formation and prevent cell death induced by the peptide in culture. It is used for the synthesis of anti-inflammatory angular pyrrolocoumarins.

Preparation

Synthesis of 4-hydroxyindole: Using resorcinol as raw material, 4-oxotetrahydrocoumarone carboxylic acid is prepared by isomerization, catalytic hydrogenation, and cyclization with ethyl bromopyruvate. It was added to methanol solution saturated with ammonia, and the reaction was heated in an autoclave to generate 4-oxotetrahydroindole. Finally, 4-hydroxyindole is obtained by dehydrogenation and isomerization.

General Description

Glucouridination of 4-hydroxyindole by human uridine 5′-diphospho-glucuronosyltransferase has been repotrted.

4-Hydroxyindole Preparation Products And Raw materials

Raw materials

Methanol solution Ethyl bromopyruvate 2,6-Dinitrotoluene tert-Butanol Paraformaldehyde Resorcinol Indole N,N-Dimethylacetamide

Preparation Products

4-(oxiranylmethoxy)-1H-indole Pindolol 4-HO-DET
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View Lastest Price from 4-Hydroxyindole manufacturers

Hebei Ganmiao New material Technology Co., LTD
Product
4-Hydroxyindole 2380-94-1
Price
US $13.00-7.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
200ton
Release date
2024-06-19
Henan Fengda Chemical Co., Ltd
Product
4-Hydroxyindole 2380-94-1
Price
US $122.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-11
LY Global chemicals co.,ltd .
Product
4-Hydroxyindole 2380-94-1
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%
Supply Ability
100kg
Release date
2023-03-09

2380-94-1, 4-HydroxyindoleRelated Search:

Indole-3-acetic acid Indometacin Protocatechuic acid Indole-3-butyric acid Pindolol 2-Methylcyclohexylamine 4,4'-Oxydianiline Bis(1,2,2,6,6-pentamethyl-4-piperidyl) sebacate 1-Chloro-3-(1H-indol-4-yloxy)-2-propanol 4-Benzyloxyindole-3-carboxaldehyde METHYL 4-METHOXY-2-INDOLECARBOXYLATE 4-Methoxyindole-3-carboxaldehyde 3-HYDROXYINDOLE 4-Methoxyindole PSILOCIN 4-Benzyloxyindole 7-HYDROXYINDOLE-2-CARBOXYLIC ACID 4-Hydroxy-2-methylindole

  • 4-Hdroxyindole
  • 4-Hydroxyindole in stock Factory
  • 1H-INDOL-4-OL
  • 1H-INDOLE-4-OL
  • 4-HYDROXY-1H-INDOLE
  • 4-INDOLOL
  • 4-HYDROXYINDOLE
  • INDOL-4-OL
  • 4-Hydroxy Indole (4-Indolol)
  • 4-Hydroxxyindole
  • 4-Hydroxyindole>99.0%
  • 4-Hydroxyindole,98%
  • 4-Hydroxylndole
  • 4-HYDROXYINDOLE(4OHI)
  • 4-Hydroxyindole,99%
  • 4-Hydroxyindole , 99.0%(GC)
  • 1H-indol-4-ol, 4- hydroxyindole
  • 4-Hydroxyindole≥ 99.5% (HPLC)
  • 1,5-Dihydro-indol-4-one
  • Pindolol EP Impurity E
  • 4-Hydroxyindole&gt
  • 4-HydroxyindoL
  • 1H-Indol-4-ol (9CI, ACI)
  • 4 Hydroxyindole,4Hydroxyindole
  • Pindolol Impurity E
  • 4-Hydroxyindole (25 mg) (1H-Indol-4-ol)
  • 4-Hydroxyindole (Standard)
  • Indololol EP Impurity E
  • 2380-94-1
  • Simple Indoles
  • Indoles
  • Building Blocks
  • ALCOHOL
  • Heterocyclic Building Blocks
  • API
  • Chemical
  • Heterocycle-Indole series
  • Indole
  • Indoles
  • Indole Derivatives
  • Simple Indoles
  • Chiral Compound
  • Pyrroles & Indoles
  • Heterocycles
  • blocks
  • IndolesOxindoles
  • Indoles and derivatives
  • pharmacetical
  • Heterocycles series
  • Pyrroles & Indoles
  • bc0001
  • 2380-94-1