4-Chloro-3-nitrobenzaldehyde
- Product Name
- 4-Chloro-3-nitrobenzaldehyde
- CAS No.
- 16588-34-4
- Chemical Name
- 4-Chloro-3-nitrobenzaldehyde
- Synonyms
- ASISCHEM R36965;AKOS BBS-00003244;TIMTEC-BB SBB007674;4-Chlor-3-nitrobenzaldehyde;4-chloro-3-nitro-benzaldehyd;4-CHLORO-3-NITROBENZALDEHYDE;3-NITRO-4-CHLOROBENZALDEHYDE;Benzaldehyde, 4-chloro-3-nitro-;1-Chloro-4-formyl-3-nitrobenzene;4-Chloro-3-nitrobenzaldehyde,97%
- CBNumber
- CB5671355
- Molecular Formula
- C7H4ClNO3
- Formula Weight
- 185.56
- MOL File
- 16588-34-4.mol
4-Chloro-3-nitrobenzaldehyde Property
- Melting point:
- 61-63 °C (lit.)
- Boiling point:
- 276.5°C (rough estimate)
- Density
- 1.4791 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- 4g/l
- form
- Powder
- color
- Off-white to light yellow to light green
- Water Solubility
- 4 g/L (98 ºC)
- Sensitive
- Air Sensitive
- BRN
- 778323
- CAS DataBase Reference
- 16588-34-4(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-Chloro-3-nitrobenzaldehyde(16588-34-4)
- EPA Substance Registry System
- Benzaldehyde, 4-chloro-3-nitro- (16588-34-4)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-43
- Safety Statements
- 26-36/37-36/37/39-22-36
- WGK Germany
- 3
- F
- 10
- Hazard Note
- Irritant
- TSCA
- Yes
- HS Code
- 29130000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C58703
- Product name
- 4-Chloro-3-nitrobenzaldehyde
- Purity
- 98%
- Packaging
- 25g
- Price
- $109.5
- Updated
- 2025/07/31
- Product number
- C58703
- Product name
- 4-Chloro-3-nitrobenzaldehyde
- Purity
- 98%
- Packaging
- 5g
- Price
- $43.3
- Updated
- 2023/06/20
- Product number
- C1165
- Product name
- 4-Chloro-3-nitrobenzaldehyde
- Purity
- >95.0%(T)
- Packaging
- 5g
- Price
- $27
- Updated
- 2025/07/31
- Product number
- C1165
- Product name
- 4-Chloro-3-nitrobenzaldehyde
- Purity
- >95.0%(T)
- Packaging
- 25g
- Price
- $74
- Updated
- 2025/07/31
- Product number
- C373990
- Product name
- 4-Chloro-3-nitrobenzaldehyde
- Packaging
- 25g
- Price
- $75
- Updated
- 2021/12/16
4-Chloro-3-nitrobenzaldehyde Chemical Properties,Usage,Production
Chemical Properties
Light yellow powder
Uses
4-Chloro-3-nitrobenzaldehyde is a potent inhibitor of VCAM-1 expression and a potential drug candidate for autoimmune and allergic inflammatory diseases.
Synthesis
104-88-1
16588-34-4
General procedure for the synthesis of 4-chloro-3-nitrobenzaldehyde from 4-chlorobenzaldehyde: 4-chlorobenzaldehyde (70 g, 0.5 mol) was added in batches to a mixture of nitrosonitrous nitric acid (55 mL) and sulfuric acid (55 mL) at 5°C with continuous stirring for 2 hours. Upon completion of the reaction, the reaction mixture was slowly poured into ice water (1 L) while stirring was maintained. Subsequently, the precipitate was collected by filtration and recrystallized with ethanol/water solvent mixture to afford the target product 4-chloro-3-nitrobenzaldehyde (90 g, 97% yield) as white needle-like crystals. The melting point of the product was 62-63 °C.
References
[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 4, p. 657 - 667
[2] European Journal of Medicinal Chemistry, 2014, vol. 77, p. 361 - 377
[3] Journal of Chemical Research, 2008, # 12, p. 722 - 724
[4] Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry, 2013, vol. 43, # 8, p. 977 - 983
[5] Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry, 2014, vol. 44, # 7, p. 921 - 926
4-Chloro-3-nitrobenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloro-3-nitrobenzaldehyde manufacturers
- Product
- 4-Chloro-3-nitrobenzaldehyde 16588-34-4
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-25
- Product
- 4-Chloro-3-nitrobenzaldehyde 16588-34-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.5%
- Supply Ability
- 100 tons
- Release date
- 2022-02-08
- Product
- 4-Chloro-3-nitrobenzaldehyde 16588-34-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 100 tons
- Release date
- 2020-01-07