DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE)
- Product Name
- DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE)
- CAS No.
- 85272-30-6
- Chemical Name
- DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE)
- Synonyms
- DK412;diisopropylbis(trifluoromethanesulfonyl)silane;DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE);Diisopropylsilylenebis(trifluoromethanesulfonate);TRIFLUOROMETHANESULFONIC ACID DIISOPROPYLSILYLENE ESTER;DIISOPROPYLSILYL BIS(TRIFLUOROMETHANE-SU LFONATE), TECH.;Bis(trifluoromethanesulfonic acid)diisopropylsilanediyl ester;Bis(1-methylethyl)[[(trifluoromethyl)sulfonyl]oxy]silyl triflate;Methanesulfonic acid, trifluoro-, bis(1-methylethyl)silylene ester;Methanesulfonic acid, 1,1,1-trifluoro-, bis(1-methylethyl)[[(trifluoromethyl)sulfonyl]oxy]silyl ester
- CBNumber
- CB5678556
- Molecular Formula
- C8H14F6O6S2Si
- Formula Weight
- 412.4
- MOL File
- 85272-30-6.mol
DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE) Property
- Boiling point:
- 85-86 °C2 mm Hg(lit.)
- Density
- 1.396 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.382(lit.)
- Flash point:
- >230 °F
- Specific Gravity
- 1.396
- Hydrolytic Sensitivity
- 8: reacts rapidly with moisture, water, protic solvents
- BRN
- 3567500
Safety
- Hazard Codes
- C
- Risk Statements
- 34-37
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- F
- 10-21
- HazardClass
- 8
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 375942
- Product name
- Diisopropylsilyl bis(trifluoromethanesulfonate)
- Purity
- 96%
- Packaging
- 5g
- Price
- $123
- Updated
- 2024/03/01
- Product number
- 375942
- Product name
- Diisopropylsilyl bis(trifluoromethanesulfonate)
- Purity
- 96%
- Packaging
- 25g
- Price
- $559
- Updated
- 2023/06/20
- Product number
- FD90402
- Product name
- Diisopropylsilyl Bis(Trifluoromethanesulfonate)
- Packaging
- 25g
- Price
- $875
- Updated
- 2021/12/16
- Product number
- FD90402
- Product name
- Diisopropylsilyl Bis(Trifluoromethanesulfonate)
- Packaging
- 5G
- Price
- $250
- Updated
- 2021/12/16
- Product number
- FD90402
- Product name
- Diisopropylsilyl Bis(Trifluoromethanesulfonate)
- Packaging
- 10g
- Price
- $400
- Updated
- 2021/12/16
DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE) Chemical Properties,Usage,Production
Physical properties
bp 85–86°C/2mmHg;d 1.396 g cm?3; fp 110°C.
Uses
Diisopropylsilyl
bis(trifluoromethanesulfonate) has more recently been
used to prepare diisopropylsilyl-linked oligonucleotide analogs.
Silylation of 5'-O-(dimethoxytrityl)-2'-deoxynucleosides using
diisopropylsilyl bis(trifluoromethanesulfonate) and the hindered
base 2,6-di-t-butyl-4-methylpyridine (Dtbp) provided quantitative
yield of 3'-O-diisopropylsilanols (eq 2). Hence, silylation
of 5'-O-(dimethoxytrityl)thymidine, N6-benzoyl-2'-deoxy-5'-O-
(dimethoxytrityl)adenosine, N4-benzoyl-2'-deoxy-5'-O-(dimethoxytrityl)
cytidine, and N2-isobutyryl-2'-deoxy-5'-O-(dimethoxytrityl)
guanosine gave the desired products 5a–d in excellent
yields.
Coupling of products 5a–d with unprotected thymidine
resulted in formation of 3',5'-linked dinucleosides 6a–d selectively,
and the dimer 7 from reaction with secondary hydroxyl
group of thymidine was not observed (eq 3). Subsequent silylation
and coupling with another molecule of thymidine gave 3,5-
linked trinucleoside 8 in 76% yield (eq 4). A tetrathymidylate oligomer was prepared by 3'-O-silylation of 8 followed by
coupling with thymidine. Although no self-condensation was
observed, only 30% of the product 9 was obtained after purification
by preparative HPLC.
Preparation
conveniently prepared by the slow addition of 2 equiv of trifluoromethanesulfonic acid to a stirring mixture of chlorodiisopropylsilane, followed by direct distillation of the product from the reaction flask to yield the product as a pale yellow oil.
DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE) Preparation Products And Raw materials
Raw materials
Preparation Products
DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE) Suppliers
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View Lastest Price from DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE) manufacturers
- Product
- diisopropylbis(trifluoromethanesulfonyl)silane 85272-30-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98%
- Supply Ability
- g/kg/ton
- Release date
- 2020-01-08