1-(2-Chloroethyl)azepane hydrochloride
- Product Name
- 1-(2-Chloroethyl)azepane hydrochloride
- CAS No.
- 26487-67-2
- Chemical Name
- 1-(2-Chloroethyl)azepane hydrochloride
- Synonyms
- Bazedoxifeno int;BAZEDOXIFENE int1;2-CHLOROETHYLHEXAMETHYLENE IMINE HCL;2-ChloroethylhexamethyleneImineHcl99%;1-(2-Chloroethyl)azepane hydrochloride;N-(2-Chloroethyl)azepane hydrochloride.;2-Chloroethylhexamethylene Imine Hcl 99%;azepin-1-yl)ethyl chloride hydrochloride;2-(HEXAMETHYLENEIMINO)ETHYL CHLORIDE HCL;1-(2-Chloroethyl)azepanehydrochloride98%
- CBNumber
- CB5693188
- Molecular Formula
- C8H17Cl2N
- Formula Weight
- 198.13
- MOL File
- 26487-67-2.mol
1-(2-Chloroethyl)azepane hydrochloride Property
- Melting point:
- 208-210°C
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- color
- White to Almost white
- Sensitive
- Hygroscopic
- BRN
- 3680388
- InChI
- InChI=1S/C8H16ClN.ClH/c9-5-8-10-6-3-1-2-4-7-10;/h1-8H2;1H
- InChIKey
- ZQDSOUPBYJIPNM-UHFFFAOYSA-N
- SMILES
- N1(CCCl)CCCCCC1.Cl
- CAS DataBase Reference
- 26487-67-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/22-36/37-39-52-22-36/38-20
- Safety Statements
- 22-26-36/37/39-51-20/21
- RIDADR
- 2811
- RTECS
- CM3185000
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29339900
- Toxicity
- mouse,LD50,intravenous,56mg/kg (56mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00612,
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C2379
- Product name
- 1-(2-Chloroethyl)-1H-hexahydroazepine Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $23
- Updated
- 2025/07/31
- Product number
- C2379
- Product name
- 1-(2-Chloroethyl)-1H-hexahydroazepine Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $58
- Updated
- 2025/07/31
- Product number
- C382485
- Product name
- 1-(2-Chloroethyl)azepaneHydrochloride
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 084387
- Product name
- 1-(2-Chloroethyl)azepane hydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- 084387
- Product name
- 1-(2-Chloroethyl)azepane hydrochloride
- Purity
- 97%
- Packaging
- 5g
- Price
- $35
- Updated
- 2021/12/16
1-(2-Chloroethyl)azepane hydrochloride Chemical Properties,Usage,Production
Uses
1-(2-Chloroethyl)azepane hydrochloride is a key intermediate of bazedoxifene and setastine.
Synthesis
2205-31-4
26487-67-2
General procedure for the synthesis of 2-(cyclohexylimino)ethyl chloride hydrochloride from 1-(2-chloroethyl)azepane: 165.9 g of isopropanol was added to the reaction system, and dry hydrogen chloride gas was slowly vented under stirring until the pH of the reaction system was ≤2.5 when the venting was stopped. The reaction mixture was heated to a maximum of 80 °C with continuous stirring for 30 minutes. Subsequently, 2.8 g of activated carbon was added and stirring was continued for 30 minutes. Upon completion of the reaction, thermal filtration was performed to remove the activated carbon. The filtrate was cooled to 0-5°C and left to crystallize for 8 hours. Upon completion of crystallization, the solid product was collected by filtration and dried to give 53.1 g of N-(2-chloroethyl)hexamethyleneimine hydrochloride in 84.5% yield. The purity of the product N-(2-chloroethyl)hexamethyleneimine hydrochloride was tested to be 98.6%.
References
[1] Patent: CN104693144, 2016, B. Location in patent: Paragraph 0030; 0033
1-(2-Chloroethyl)azepane hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
1-(2-Chloroethyl)azepane hydrochloride Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
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- Advantage
- 75
View Lastest Price from 1-(2-Chloroethyl)azepane hydrochloride manufacturers
- Product
- 1-(2-Chloroethyl)azepane hydrochloride 26487-67-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2025-04-11
- Product
- 1-(2-Chloroethyl)azepane hydrochloride (1:1) 26487-67-2
- Price
- US $20.00/KG
- Min. Order
- 1KG
- Purity
- >99%
- Supply Ability
- 50000kg/Month
- Release date
- 2023-03-17
- Product
- 1-(2-Chloroethyl)azepane hydrochloride (1:1) 26487-67-2
- Price
- US $10.00/KG
- Min. Order
- 0.5KG
- Purity
- >99%
- Supply Ability
- 20tons
- Release date
- 2020-12-28